Animal Models for Human Diseases: Advances in Genome Editing

Dear Colleagues,

Animal models of human diseases are essential for understanding disease mechanisms and developing new treatments. Animal models are often selected because of their similarity to humans in terms of genetics, anatomy, and physiology. They are also often preferable for experimental disease research because of their unlimited supply and ease of manipulation. Genome editing technologies, such as CRISPR-Cas9, have revolutionized the creation of animal models by allowing for precise and efficient genetic modifications. This has enabled the development of new models of a wide range of human diseases, including genetic disorders, cancer, and infectious diseases.

Animal models generated using genome editing have several advantages over traditional models. First, they can be designed to recapitulate the genetic and phenotypic features of human diseases with greater accuracy. Second, they can be used to study the effects of genetic mutations on different tissues and organs. Third, they can be used to screen new drugs and therapies in a preclinical setting.

As genome editing technology continues to improve, we can expect to see even more sophisticated and informative models being developed. This will help us to better understand human diseases and develop new and more effective treatments.

This Special Issue will cover all aspects of modelling human diseases in various animal species via genome editing, present recent developments of novel transgenic tools and their applications and provide validation that such models can be successfully used in biomedical research.

Dr. Andrei Golovko
Guest Editor

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• genome editing
• CRISPR-Cas9
• disease models
• genetic modifications
• knockout
• knock-in
• indel
• point mutation
• phenotype