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Plasma Bioscience and Medicine Molecular Research 2.0
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Plasma Bioscience and Medicine Molecular Research 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biophysics".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 4387

Special Issue Editor

Prof. Dr. Nagendra Kumar Kaushik

E-Mail Website
Guest Editor
Plasma Bioscience Research Center, Department of Electrical and Biological Physics, Kwangwoon University, Seoul 01897, Republic of Korea
Interests: plasma medicine; cancers; immune modulations; cell signaling; molecular responses; biomaterials; nanomaterials; virus biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Plasma medicine is an interdisciplinary field that combines the principles of plasma physics, material science, bioscience, and medicine toward the development of therapeutic strategies. The study of plasma medicine has yielded the development of new treatment opportunities in medical and dental sciences.

The objective of this Special Issue is to present research underlying nonthermal gas plasma therapeutic methods useful in medicine, skin, aesthetics, food processing, decontamination, sterilization, and, in the current scenario, challenges and perspectives in biomedical sciences. Plasma medicine researchers are focused on basic studies on the characterization of the bioplasma sources applicable to living cells, especially to the human body, and fundamental research on mutual interactions between bioplasma and organic–inorganic, liquid, and bio- or nanomaterials. The knowledge that has arisen from studies in plasma medicine may translate into innovations to treat patients in daily clinics. Plasma is also used in many ways in the field of agriculture and food processing. Although the processes that accompany the development of plasma-based applications are known, the underlying molecular basis is less understood. For that, knowing new mechanisms and molecular events that participate in this plasma-induced biological process is fundamental to understand its development and would allow having new targets for biological applications or new treatment strategies.

With this Special Issue of IJMS, we aim to offer a platform for high-quality publications on nonthermal plasma-based new mechanisms and molecular responses.

Prof. Dr. Nagendra Kumar Kaushik
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plasma medicine
  • nonthermal plasma
  • biomaterials
  • cell biology
  • cancer treatments
  • immuno-modulations
  • stem cells
  • nanomaterials
  • plasma agriculture
  • food processing
  • virus inactivation
  • antimicrobial activities

Related Special Issue

Published Papers (4 papers)

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Research

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18 pages, 2542 KiB  
Article
Cold Atmospheric Pressure Plasma-Activated Medium Modulates Cellular Functions of Human Mesenchymal Stem/Stromal Cells In Vitro
by Olga Hahn, Tawakalitu Okikiola Waheed, Kaarthik Sridharan, Thomas Huemerlehner, Susanne Staehlke, Mario Thürling, Lars Boeckmann, Mareike Meister, Kai Masur and Kirsten Peters
Int. J. Mol. Sci. 2024, 25(9), 4944; https://doi.org/10.3390/ijms25094944 - 1 May 2024
Viewed by 333
Abstract
Cold atmospheric pressure plasma (CAP) offers a variety of therapeutic possibilities and induces the formation of reactive chemical species associated with oxidative stress. Mesenchymal stem/stromal cells (MSCs) play a central role in tissue regeneration, partly because of their antioxidant properties and ability to [...] Read more.
Cold atmospheric pressure plasma (CAP) offers a variety of therapeutic possibilities and induces the formation of reactive chemical species associated with oxidative stress. Mesenchymal stem/stromal cells (MSCs) play a central role in tissue regeneration, partly because of their antioxidant properties and ability to migrate into regenerating areas. During the therapeutic application, MSCs are directly exposed to the reactive species of CAP. Therefore, the investigation of CAP-induced effects on MSCs is essential. In this study, we quantified the amount of ROS due to the CAP activation of the culture medium. In addition, cell number, metabolic activity, stress signals, and migration were analyzed after the treatment of MSCs with a CAP-activated medium. CAP-activated media induced a significant increase in ROS but did not cause cytotoxic effects on MSCs when the treatment was singular and short-term (one day). This single treatment led to increased cell migration, an essential process in wound healing. In parallel, there was an increase in various cell stress proteins, indicating an adaptation to oxidative stress. Repeated treatments with the CAP-activated medium impaired the viability of the MSCs. The results shown here provide information on the influence of treatment frequency and intensity, which could be necessary for the therapeutic application of CAP. Full article
(This article belongs to the Special Issue Plasma Bioscience and Medicine Molecular Research 2.0)
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16 pages, 4262 KiB  
Article
Plasma-Activated Media Produced by a Microwave-Excited Atmospheric Pressure Plasma Jet Is Effective against Cisplatin-Resistant Human Bladder Cancer Cells In Vitro
by Ara Jo, Hea-Min Joh, Jin-Hee Bae, Sun-Ja Kim, Jin-Woong Chung and Tae-Hun Chung
Int. J. Mol. Sci. 2024, 25(2), 1249; https://doi.org/10.3390/ijms25021249 - 19 Jan 2024
Viewed by 745
Abstract
Media exposed to atmospheric pressure plasma (APP) produce reactive oxygen and nitrogen species (RONS), with hydrogen peroxide (H2O2), nitrite (NO2−), and nitrate (NO3−) being among the most detected species due to their relatively [...] Read more.
Media exposed to atmospheric pressure plasma (APP) produce reactive oxygen and nitrogen species (RONS), with hydrogen peroxide (H2O2), nitrite (NO2−), and nitrate (NO3−) being among the most detected species due to their relatively long lifetime. In this study, a standardized microwave-excited (ME) APP jet (APPJ) source was employed to produce gaseous RONS to treat liquid samples. The source was a commercially available plasma jet, which generated argon plasma utilizing a coaxial transmission line resonator at the operating frequency of 2.45 GHz. An ultraviolet-visible spectrophotometer was used to measure the concentrations of H2O2 and NO3− in plasma-activated media (PAM). Three different types of media (deionized water, Hank’s balanced salt solution, and cell culture solution Dulbecco’s modified eagles medium [DMEM]) were utilized as liquid samples. Among these media, the plasma-treated DMEM was observed to have the highest levels of H2O2 and NO3−. Subsequently, the feasibility of using argon ME-APPJ-activated DMEM (PAM) as an adjuvant to enhance the therapeutic effects of cisplatin on human bladder cancer cells (T-24) was investigated. Various cancer cell lines, including T-24 cells, treated with PAM were observed in vitro for changes in cell viability using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. A viability reduction was detected in the various cancer cells after incubation in PAM. Furthermore, the study’s results revealed that PAM was effective against cisplatin-resistant T-24 cells in vitro. In addition, a possible connection between HER expression and cell viability was sketched. Full article
(This article belongs to the Special Issue Plasma Bioscience and Medicine Molecular Research 2.0)
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20 pages, 5433 KiB  
Article
Atmospheric and Room Temperature Plasma (ARTP) Mutagenesis Improved the Anti-MRSA Activity of Brevibacillus sp. SPR20
by Nuttapon Songnaka, Monthon Lertcanawanichakul, Albert Manggading Hutapea, Mudtorlep Nisoa, Sucheewin Krobthong, Yodying Yingchutrakul and Apichart Atipairin
Int. J. Mol. Sci. 2023, 24(15), 12016; https://doi.org/10.3390/ijms241512016 - 27 Jul 2023
Cited by 1 | Viewed by 1470
Abstract
Brevibacillus sp. SPR20 produced potentially antibacterial substances against methicillin-resistant Staphylococcus aureus (MRSA). The synthesis of these substances is controlled by their biosynthetic gene clusters. Several mutagenesis methods are used to overcome the restriction of gene regulations when genetic information is absent. Atmospheric and [...] Read more.
Brevibacillus sp. SPR20 produced potentially antibacterial substances against methicillin-resistant Staphylococcus aureus (MRSA). The synthesis of these substances is controlled by their biosynthetic gene clusters. Several mutagenesis methods are used to overcome the restriction of gene regulations when genetic information is absent. Atmospheric and room temperature plasma (ARTP) is a powerful technique to initiate random mutagenesis for microbial strain improvement. This study utilized an argon-based ARTP to conduct the mutations on SPR20. The positive mutants of 40% occurred. The M27 mutant exhibited an increase in anti-MRSA activity when compared to the wild-type strain, with the MIC values of 250–500 and 500 μg/mL, respectively. M27 had genetic stability because it exhibited constant activity throughout fifteen generations. This mutant had similar morphology and antibiotic susceptibility to the wild type. Comparative proteomic analysis identified some specific proteins that were upregulated in M27. These proteins were involved in the metabolism of amino acids, cell structure and movement, and catalytic enzymes. These might result in the enhancement of the anti-MRSA activity of the ARTP-treated SPR20 mutant. This study supports the ARTP technology designed to increase the production of valuable antibacterial agents. Full article
(This article belongs to the Special Issue Plasma Bioscience and Medicine Molecular Research 2.0)
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Review

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22 pages, 6681 KiB  
Review
Cold Atmospheric Pressure Plasma: A Growing Paradigm in Diabetic Wound Healing—Mechanism and Clinical Significance
by Azadeh Barjasteh, Neha Kaushik, Eun Ha Choi and Nagendra Kumar Kaushik
Int. J. Mol. Sci. 2023, 24(23), 16657; https://doi.org/10.3390/ijms242316657 - 23 Nov 2023
Viewed by 1217
Abstract
Diabetes is one of the most significant causes of death all over the world. This illness, due to abnormal blood glucose levels, leads to impaired wound healing and, as a result, foot ulcers. These ulcers cannot heal quickly in diabetic patients and may [...] Read more.
Diabetes is one of the most significant causes of death all over the world. This illness, due to abnormal blood glucose levels, leads to impaired wound healing and, as a result, foot ulcers. These ulcers cannot heal quickly in diabetic patients and may finally result in amputation. In recent years, different research has been conducted to heal diabetic foot ulcers: one of them is using cold atmospheric pressure plasma. Nowadays, cold atmospheric pressure plasma is highly regarded in medicine because of its positive effects and lack of side effects. These conditions have caused plasma to be considered a promising technology in medicine and especially diabetic wound healing because studies show that it can heal chronic wounds that are resistant to standard treatments. The positive effects of plasma are due to different reactive species, UV radiation, and electromagnetic fields. This work reviews ongoing cold atmospheric pressure plasma improvements in diabetic wound healing. It shows that plasma can be a promising tool in treating chronic wounds, including ones resulting from diabetes. Full article
(This article belongs to the Special Issue Plasma Bioscience and Medicine Molecular Research 2.0)
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