Mitogen Activated Protein Kinases: Functions in Signal Transduction and Human Diseases 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 October 2020) | Viewed by 8222
Special Issue Editor
Interests: lysosomal storage disorders; vesicular trafficking; endosomal sorting; lysosome biogenesis; mitochondrial diseases; autoimmune disorders
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mitogen-activated protein (MAP) kinases are a large family of enzymes that function as signal transducers to regulate a diverse range of physiological and pathologic cellular responses. This signalling operates via a hierarchical cascade involving MAP3K, MAP2K and MAPK enzymes. Most studies have focused on the MAPK family, extracellular signal-regulated kinase (ERK), c-Jun amino terminal kinase (JNK) and p38 MAPK. There is considerable variation in MAP kinase functions across different cell types that make it challenging to extrapolate, from in vitro studies, to the whole organism. There is substantial interest in therapeutic targeting of individual MAP kinase enzymes in diseases ranging from cancer to chronic organ fibrosis.
This Special Issue of the International Journal of Molecular Sciences will focus on “Mitogen Activated Protein Kinases: Functions in Signal Transduction and Human Diseases”. We welcome contributions on the regulation of MAP kinase functions in terms of how the signalling cascade is activated by different stimuli, signal transduction via scaffolding proteins, and termination of signalling via phosphatase enzymes. In addition, we welcome contributions examining the role of MAP kinases in pathogenesis in human and experimental disease; including tissue damage and repair mechanisms.
Prof. Dr. Ritva Tikkanen
Guest Editor
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Keywords
- MAP kinase
- p38 MAPK
- JNK
- ERK
- Disease pathogenesis
- Kinase inhibition
- Phosphatase
- Cancer
- Signal transduction
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