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Mitogen Activated Protein Kinases: Functions in Signal Transduction and Human Diseases 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 October 2020) | Viewed by 8222

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Special Issue Information

Dear Colleagues,

Mitogen-activated protein (MAP) kinases are a large family of enzymes that function as signal transducers to regulate a diverse range of physiological and pathologic cellular responses. This signalling operates via a hierarchical cascade involving MAP3K, MAP2K and MAPK enzymes. Most studies have focused on the MAPK family, extracellular signal-regulated kinase (ERK), c-Jun amino terminal kinase (JNK) and p38 MAPK. There is considerable variation in MAP kinase functions across different cell types that make it challenging to extrapolate, from in vitro studies, to the whole organism. There is substantial interest in therapeutic targeting of individual MAP kinase enzymes in diseases ranging from cancer to chronic organ fibrosis.

This Special Issue of the International Journal of Molecular Sciences will focus on “Mitogen Activated Protein Kinases: Functions in Signal Transduction and Human Diseases”. We welcome contributions on the regulation of MAP kinase functions in terms of how the signalling cascade is activated by different stimuli, signal transduction via scaffolding proteins, and termination of signalling via phosphatase enzymes. In addition, we welcome contributions examining the role of MAP kinases in pathogenesis in human and experimental disease; including tissue damage and repair mechanisms.

Prof. Dr. Ritva Tikkanen
Guest Editor

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Keywords

  • MAP kinase
  • p38 MAPK
  • JNK
  • ERK
  • Disease pathogenesis
  • Kinase inhibition
  • Phosphatase
  • Cancer
  • Signal transduction

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Published Papers (1 paper)

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Review

17 pages, 640 KiB  
Review
Organophosphorus Compounds and MAPK Signaling Pathways
by Tahereh Farkhondeh, Omid Mehrpour, Constanze Buhrmann, Ali Mohammad Pourbagher-Shahri, Mehdi Shakibaei and Saeed Samarghandian
Int. J. Mol. Sci. 2020, 21(12), 4258; https://doi.org/10.3390/ijms21124258 - 15 Jun 2020
Cited by 57 | Viewed by 7550
Abstract
The molecular signaling pathways that lead to cell survival/death after exposure to organophosphate compounds (OPCs) are not yet fully understood. Mitogen-activated protein kinases (MAPKs) including the extracellular signal-regulated protein kinase (ERK), the c-Jun NH2-terminal kinase (JNK), and the p38-MAPK play the leading roles [...] Read more.
The molecular signaling pathways that lead to cell survival/death after exposure to organophosphate compounds (OPCs) are not yet fully understood. Mitogen-activated protein kinases (MAPKs) including the extracellular signal-regulated protein kinase (ERK), the c-Jun NH2-terminal kinase (JNK), and the p38-MAPK play the leading roles in the transmission of extracellular signals into the cell nucleus, leading to cell differentiation, cell growth, and apoptosis. Moreover, exposure to OPCs induces ERK, JNK, and p38-MAPK activation, which leads to oxidative stress and apoptosis in various tissues. However, the activation of MAPK signaling pathways may differ depending on the type of OPCs and the type of cell exposed. Finally, different cell responses can be induced by different types of MAPK signaling pathways after exposure to OPCs. Full article
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