Autoimmune Diseases: Molecular Mechanisms and Therapies
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 33697
Special Issue Editors
Interests: lysosomal storage disorders; vesicular trafficking; endosomal sorting; lysosome biogenesis; mitochondrial diseases; autoimmune disorders
Special Issues, Collections and Topics in MDPI journals
Interests: mTOR; inflammation; tissue engineering; dermatology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Autoimmune diseases are caused by the breakage of self-tolerance and the appearance of pathogenic antibodies against normal tissue proteins. These autoantibodies may have a direct, damaging effect on their target tissues, or the autoantibodies may stimulate and activate receptor molecules and induce aberrant downstream effects. Autoimmune diseases target various tissues, such as the epidermis, thyroid, neuromuscular junction, myelinated nerves or the pancreas. The resulting tissue damage is frequently associated with profound inflammation, and the first line of treatment has traditionally been anti-inflammatory therapy with corticosteroids. However, more targeted therapies against specific molecules, such as the CD20 surface antigen (rituximab) or the neonatal Fc receptor, have started to emerge.
The purpose of this Special Issue is to provide an overview of the molecular mechanisms of human autoimmune diseases and their therapies. We especially welcome manuscripts addressing novel molecular mechanisms of treatments for autoimmune diseases, as well as the characterization of autoantibody effects on their target cells and cellular responses induced by autoantibodies, including signaling. We encourage submission of review articles and original research papers of any length. Our aim is to provide a comprehensive update on autoimmune diseases, their pathomechanisms and therapy options.
Prof. Dr. Ritva Tikkanen
Prof. Dr. Claudia Bürger
Guest Editors
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Keywords
- autoimmune diseases
- immunity
- tolerance
- epidermis
- thyroid
- pancreas
- pemphigus
- pemphigoid
- diabetes
- myasthenia gravis
- multiple sclerosis
- Sjögren syndrome
- ITPP
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