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MSC-Based Therapies for Tissue Regeneration
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MSC-Based Therapies for Tissue Regeneration

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 2261

Special Issue Editors

Prof. Dr. Marco Tatullo

E-Mail Website
Guest Editor
Full Professor, Department of Translational Biomedicine and Neuroscience (DiBraiN), University of Bari “Aldo Moro”, 70121 Bari, Italy
Interests: regenerative medicine; regenerative dentistry; stem cells; MSCs; biomaterials; growth factors; PRF; PRP; tissue engineering; biomimetics
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Gaetano Marenzi

E-Mail Website
Guest Editor
Department of Neurosciences, Reproduction and Odontostomatological Sciences, University of Naples Federico II Via S. Pansini 5, 80131 Napoli, Italy
Interests: osseointegration; tissue regeneration; platelet concentrates; implant surface; implant aesthetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The Special Issue titled "MSC-Based Therapies for Tissue Regeneration" focuses on the emerging field of mesenchymal stem cell (MSC) therapies and their potential for tissue regeneration. MSCs are a type of adult stem cells that possess remarkable regenerative properties and can differentiate into various cell types found in different tissues. This Special Issue aims to explore the latest advancements, challenges, and future prospects of MSC-based therapies in tissue regeneration.

The issue will accept articles on basic biology and translational applications of human MSCs, highlighting their potential for tissue repair and regeneration. It also welcomes original articles on specific applications of MSCs in various tissue types, including bone, cartilage, muscle, heart, liver, and nervous system. Overall, the Special Issue aims to address the key challenges in MSC-based therapies, such as optimizing cell sourcing, enhancing cell delivery methods, and understanding the mechanisms of MSC-mediated tissue repair.

Prof. Dr. Marco Tatullo
Prof. Dr. Gaetano Marenzi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • regenerative medicine
  • translational medicine
  • stem cells
  • biomaterials
  • dentistry
  • dental materials
  • scaffolds
  • tissue engineering

Published Papers (2 papers)

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Research

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12 pages, 3226 KiB  
Article
BMSC–HNC Interaction: Exploring Effects on Bone Integrity and Head and Neck Cancer Progression
by Jonas Eichberger, Daniel Froschhammer, Daniela Schulz, Konstantin J. Scholz, Marianne Federlin, Helga Ebensberger, Torsten E. Reichert, Tobias Ettl and Richard J. Bauer
Int. J. Mol. Sci. 2023, 24(19), 14417; https://doi.org/10.3390/ijms241914417 - 22 Sep 2023
Viewed by 883
Abstract
In recent research, the tumor microenvironment has been shown to attract mesenchymal stromal cells (MSCs), which is of particular interest due to its implications for cancer progression. The study focused on understanding the interaction between bone marrow-derived MSCs (BMSCs) and head and neck [...] Read more.
In recent research, the tumor microenvironment has been shown to attract mesenchymal stromal cells (MSCs), which is of particular interest due to its implications for cancer progression. The study focused on understanding the interaction between bone marrow-derived MSCs (BMSCs) and head and neck cancer (HNC) cells. This interaction was found to activate specific markers, notably the osteogenic marker alkaline phosphatase and the oncogene Runx2. These activations corresponded with the release of collagenase enzymes, MMP9 and MMP2. To gain insights into bone resorption related to this interaction, bovine bone slices were used, supporting the growth of “heterogeneous spheroids” that contained both BMSCs and HNC cells. Through scanning electron microscopy and energy-dispersive X-ray (EDX) analysis, it was observed that these mixed spheroids were linked to a notable increase in bone degradation and collagen fiber exposure, more so than spheroids of just BMSCs or HNC cells. Furthermore, the EDX results highlighted increased nitrogen content on bone surfaces with these mixed clusters. Overall, the findings underscore the significant role of BMSCs in tumor growth, emphasizing the need for further exploration in potential cancer treatment strategies. Full article
(This article belongs to the Special Issue MSC-Based Therapies for Tissue Regeneration)
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Review

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15 pages, 1445 KiB  
Review
Adipose-Derived Stem Cells to Treat Ischemic Diseases: The Case of Peripheral Artery Disease
by Gemma Arderiu, Anna Civit-Urgell and Lina Badimon
Int. J. Mol. Sci. 2023, 24(23), 16752; https://doi.org/10.3390/ijms242316752 - 25 Nov 2023
Cited by 1 | Viewed by 1010
Abstract
Critical limb ischemia incidence and prevalence have increased over the years. However, there are no successful treatments to improve quality of life and to reduce the risk of cardiovascular and limb events in these patients. Advanced regenerative therapies have focused their interest on [...] Read more.
Critical limb ischemia incidence and prevalence have increased over the years. However, there are no successful treatments to improve quality of life and to reduce the risk of cardiovascular and limb events in these patients. Advanced regenerative therapies have focused their interest on the generation of new blood vessels to repair tissue damage through the use of stem cells. One of the most promising sources of stem cells with high potential in cell-based therapy is adipose-derived stem cells (ASCs). ASCs are adult mesenchymal stem cells that are relatively abundant and ubiquitous and are characterized by a multilineage capacity and low immunogenicity. The proangiogenic benefits of ASCs may be ascribed to: (a) paracrine secretion of proangiogenic molecules that may stimulate angiogenesis; (b) secretion of microvesicles/exosomes that are also considered as a novel therapeutic prospect for treating ischemic diseases; and (c) their differentiation capability toward endothelial cells (ECs). Although we know the proangiogenic effects of ASCs, the therapeutic efficacy of ASCs after transplantation in peripheral artery diseases patients is still relatively low. In this review, we evidence the potential therapeutic use of ASCs in ischemic regenerative medicine. We also highlight the main challenges in the differentiation of these cells into functional ECs. However, significant efforts are still needed to ascertain relevant transcription factors, intracellular signaling and interlinking pathways in endothelial differentiation. Full article
(This article belongs to the Special Issue MSC-Based Therapies for Tissue Regeneration)
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