Special Issue "Inhibitors of Melanogenesis Related Processes: Application to Food and Cosmetic Industry"
Deadline for manuscript submissions: closed (31 March 2010)
Prof. Dr. Manickam Sugumaran (Website)
Department of Biology, University of Massachusetts Boston, 100 Morrissey Blvd, Boston, MA 02125, USA
Phone: +1 617-287-6598
Fax: +1 617 287 6650
Interests: enzymology; post translational modifications; aromatic metabolism; phenolic biochemistry; reactions of quinonoid compounds; invertebrate immunity; insect cuticular sclerotization; phenoloxidase; quinone isomerases; oxidative browning; melanin biosynthesis; catecholic antibiotics
Melanogenesis occurs ubiquitously in microorganism, plants and all animals. The enzyme tyrosinase also known as phenoloxidase initiates this process by hydroxylating monphenols to o-diphenols and further oxidizing o-diphenols to o-quinones. O-Quinones being unstable, undergo rapid nonenzymatic as well as enzyme catalyzed transformations to eventually produce different kinds of polymeric products. Quinones in general are very reactive and tend to deplete cellular antioxidant pools as well as cause deleterious effects on cellular macromolecules. In plants, such oxidative browning reactions reduce the nutritive values thereby helping the plant to cope up with infections and invasions. Oxidative browning certainly reduces the consume ability and hence their market value. The melanosis observed in crustaceans similarly reduces the market value of sea food drastically. In arthropods and especially insects, melanogenesis is used for wound healing and defense reactions. Mammals use melanin mostly as skin, coat and eye pigments. Therefore, prevention of oxidative browning of plant products as well as sea food, alteration of skin color, and prevention and/or reduction of melanogenesis in animals has great commercial potentials. This special edition will cover a broad range of phenoloxidase/tyrosinase chemistry, biochemistry of inhibitor and ways to develop new and novel natural and synthetic bioactive compounds against melanogenesis and related process.
Prof. Dr. Manickam Sugumaran
- phenoloxidase inhibitors
- tyrosinase inhibitors
- inhibitors of melanogenesis
- skin color lightening