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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic. The journal’s Editor-in-Chief and/or designated EBM will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Advances in Molecular Pathophysiology of Cardiovascular Diseases 2.0 submission deadline 5 May 2024 | 2 articles | Viewed by 2211 | Submission Open
Keywords: DNA; genes; heart diseases; hypertrophy; molecular biology; myocardial infarction
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Aspects of the Neurodegenerative Brain Diseases
edited by
submission deadline 10 May 2024 | 7 articles | Viewed by 11521 | Submission Open
Keywords: brain-related disorder; neurodegenerative disease; biomolecule cue; biochemical cue; molecular mechanism; ligand– receptor interaction; drug response
(This special issue belongs to the Section Molecular Neurobiology)
Recent Advances in the Molecular Biology of Transplantation
edited by Kun-Ming Chan
submission deadline 10 May 2024 | 9 articles | Viewed by 10354 | Submission Open
Keywords: transplantation; donor; recipient; patient survival; graft
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Chronic Rhinosinusitis: Aetiology, Immunology and Treatment 2.0
edited by
submission deadline 10 May 2024 | 10 articles | Viewed by 9596 | Submission Open
Keywords: innate immunity; adaptive immunity; protease; cytokine; inflammation; epithelial cells; fibroblasts; eosinophils; lymphocytes; biologics
(This special issue belongs to the Section Molecular Immunology)
Regeneration for Spinal Diseases 4.0 submission deadline 10 May 2024 | 7 articles | Viewed by 7041 | Submission Open
Keywords: regeneration; intervertebral disc degeneration; spinal cord injury; osteoporosis; spinal fusion; muscle regeneration
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Regulatory Roles of Inflammation and Inflammasomes in Liver Diseases
edited by and
submission deadline 10 May 2024 | 4 articles | Viewed by 5675 | Submission Open
Keywords: inflammation; inflammasome; inflammatory responses; liver diseases
(This special issue belongs to the Section Molecular Immunology)
Key Advances in Cardiovascular Diseases submission deadline 10 May 2024 | 1 articles | Viewed by 4260 | Submission Open
Keywords: preventive cardiology; interventional cardiology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Olive Oil and Derivatives for Human Health
edited by
submission deadline 10 May 2024 | 2 articles | Viewed by 4099 | Submission Open
Keywords: extra-virgin olive oil; olive oil; oleic acid; EVOO phenolics; oleocanthal; olive leaf extract; human diseases; neurodegenerative diseases; cardiovascular disease; cancer; mechanism of action
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advances in Proteolysis and Proteolytic Enzymes submission deadline 10 May 2024 | 2 articles | Viewed by 3593 | Submission Open
Keywords: proteolysis; proteolytic enzymes; kinetics; enzyme specificity; hydrolysis of peptide bonds; bioactive peptides; demasking of peptide bonds; peptide release; modeling
(This special issue belongs to the Section Molecular Biology)
Advances in Salivary and Oral Cavity Diagnostics, Molecular Mechanisms, and Treatment
edited by and Doron J Aframian
submission deadline 10 May 2024 | 2 articles | Viewed by 2601 | Submission Open
Keywords: oral cavity diagnostics: biomarkers; screening; diagnosis; treatment response; prognosis; salivary diagnostics: salivary cytokines; salivary biomarkers; oral cavity and salivary therapy: drug design; targeted therapy; personalized medicine; molecular mechanisms and multi-omics in the oral cavity and salivary glands: genomics; epigenomics; proteomics; metabolomics; microarray techniques; next-generation sequencing; and other omics technologies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
CRISPR Base Editor for Molecular Plant Sciences
edited by
submission deadline 10 May 2024 | 1 articles | Viewed by 2286 | Submission Open
Keywords: genome editing; CRISPR; plant; crop; molecular breeding; gene discovery; CRISPR-mediated plant base editors
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms and Therapeutic Strategies of Inflammatory Pain
edited by
submission deadline 10 May 2024 | 1 articles | Viewed by 1623 | Submission Open
Keywords: inflammation; inflammatory pain; molecular mechanism; central sensitization
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Exploring Cytochromes P450: Drug Metabolism, Endogenous Metabolism, and Human Health
edited by Ewa Bromek, and Wojciech Kuban
submission deadline 10 May 2024 | 2 articles | Viewed by 1527 | Submission Open
Keywords: cytochrome P450; drug metabolism; endogenous substrate metabolism; liver metabolism; brain metabolism
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Aspects of Design, Functioning and Mechanisms of Chemical/Electrochemical Processes of Power Sources submission deadline 10 May 2024 | 1 articles | Viewed by 1199 | Submission Open
Keywords: chemical power sources; electrode materials; electrolytes; reagents; membranes; electrochemical reactions; ionic transport; mechanisms of electrochemical processes; homogeneous and heterogeneous catalysis
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Self- and Forced Assembly of Polymer Systems: Experiment, Theory and Simulation
edited by
submission deadline 10 May 2024 | 1 articles | Viewed by 1085 | Submission Open
Keywords: amphiphilic polymers; molecular "recognition"; micelles; globules; liposomes; polymer complexes aggregaton; micropase segregation; block copolymers; liquid crystals
(This special issue belongs to the Section Macromolecules)
The Role of Platelets in Development and Disease: Thrombosis across the Lifespan
edited by
submission deadline 10 May 2024 | 1 articles | Viewed by 1016 | Submission Open
Keywords: mechanobiology; biomechanics; signaling pathways; computational modeling; thrombosis; antithrombotic therapy; aging; systems biology; cardiovascular disease; diabetes; inflammation; cancer; platelet activation; platelet adhesion; platelet aggregation
(This special issue belongs to the Section Molecular Biology)
Pesticide Exposure and Toxicity 2.0
edited by
submission deadline 10 May 2024 | 1 articles | Viewed by 822 | Submission Open
Keywords: multiple pesticides; cumulative assessment; probabilistic assessment; mechanisms of molecular toxicology
(This special issue belongs to the Section Molecular Toxicology)
Forward in Vasculitis: Genetics and Beyond
edited by
submission deadline 12 May 2024 | 2 articles | Viewed by 1393 | Submission Open
Keywords: systemic vasculitides; ethiopathogenesis; risk factors; genetics; genomics; proteomics; transcriptomics; epigenetics; molecular pathways; novel therapeutic strategies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Therapies of Pancreatic Cancer submission deadline 15 May 2024 | 13 articles | Viewed by 17317 | Submission Open
Keywords: pancreatic cancer; metabolism; cellular plasticity; tumor microenvironment; target therapy
(This special issue belongs to the Section Molecular Oncology)
Cannabis sativa: From Plants to Humans submission deadline 15 May 2024 | 7 articles | Viewed by 17278 | Submission Open
Keywords: Cannabis sativa; hemp; fiber; biofuel; cannabinoids; nutritional quality; health benefits; phytoremediation
(This special issue belongs to the Section Molecular Biology)
Transcriptional Regulation of Late Oogenesis and Early Embryogenesis submission deadline 15 May 2024 | 10 articles | Viewed by 16025 | Submission Open
Keywords: transcription activity of oocytes; zygotes and early embryos; transcriptomes of oocytes and early embryos; chromatin remodeling; histone and non-histone proteins; coding and non-coding RNAs; DNA methylation
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms of Toxic and Activated Effects of Exogenous Compounds submission deadline 15 May 2024 | 10 articles | Viewed by 14095 | Submission Open
Keywords: exogenous compounds; bioeffects; toxicity; low-concentration exposures; high concentrations exposures; low-dose effects; activated effects
(This special issue belongs to the Section Biochemistry)
Calcium Signaling in Mammalian Cells: From Physiology to Pathology
edited by
submission deadline 15 May 2024 | 6 articles | Viewed by 12421 | Submission Open
Keywords: Ca2+ signaling; excitable cells; Ca2+ transporting systems; calcium-binding proteins; calcium dysregulation; signal transduction; G-protein coupled receptors; apoptosis
(This special issue belongs to the Section Biochemistry)
Molecular Research on Autophagy
edited by
submission deadline 15 May 2024 | 7 articles | Viewed by 12281 | Submission Open
Keywords: ATG molecules; transcriptional and post translational modification; selective pathways; secretory pathways; complexes diseases; degenerative processes; inflammatory diseases; tumorigenesis; metabolism; proteostasis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Genetics of Drosophila Development
edited by
submission deadline 15 May 2024 | 12 articles | Viewed by 12001 | Submission Open
Keywords: Drosophila development; metamorphosis; imaginal discs; differentiation; tissue specification; regeneration; proliferation; neural stem cells; nuclear receptor; ecdysone cascade; hippo signalling pathway; notch signalling pathway; hedgehog signalling pathway; wnt/wingless signalling pathway  
(This special issue belongs to the Section Molecular Genetics and Genomics)
Recent Molecular Research on Preeclampsia submission deadline 15 May 2024 | 11 articles | Viewed by 11874 | Submission Open
Keywords: preeclampsia; molecular signaling; transcription factors; translational regulation; genetic predisposition; epigenetic regulation; angiogenic markers; inflammation markers; metabolomics; transcriptomics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Pharmacological Activities of Secondary Metabolites and Derivates of Medicinal Plants around the World
edited by
submission deadline 15 May 2024 | 7 articles | Viewed by 11845 | Submission Open
Keywords: natural products; secondary metabolites; medicinal chemistry; worldwide traditional medicine; isolation and identification of secondary metabolites; experimental studies; phytochemistry; pharmacognosy; medicinal plants
(This special issue belongs to the Section Molecular Pharmacology)
Fish Genomics and Developmental Biology submission deadline 15 May 2024 | 9 articles | Viewed by 10913 | Submission Open
Keywords: genomics; development; teleost; aquaculture; transcriptomics; gene expression; environment; genomes; comparative genomics; population genomics; selective breeding; biomarker
(This special issue belongs to the Section Molecular Biology)
Transcriptional Regulation and Its Misregulation in Human Diseases: Recent Progress submission deadline 15 May 2024 | 5 articles | Viewed by 10270 | Submission Open
Keywords: transcription machinery; transcription factors; transcription cofactors and complexes; chromatin regulators; splicing regulators; noncoding RNAs; posttranscriptional modifications; transcription misregulation; genetic alterations; human diseases
(This special issue belongs to the Section Molecular Biology)
Whole-Cell System and Synthetic Biology
edited by and
submission deadline 15 May 2024 | 6 articles | Viewed by 10182 | Submission Open
Keywords: synthesis biology; molecular biology; functional nucleic acids; biosensor; CRISPR-Cas; directed evolution; whole-cell system
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Molecular Mechanisms of Human Papillomavirus Family (HPV) Induced Oncogenesis
edited by
submission deadline 15 May 2024 | 5 articles | Viewed by 9875 | Submission Open
Keywords: human papillomavirus (HPV); oncogenesis; mechanism; diagnosis; classification; etiology; pathophysiology; biochemistry; genetics; molecular biology; epidemiology; cervical cancer; oropharyngeal cancer; oncology
(This special issue belongs to the Section Molecular Oncology)
Hormone Receptor in Breast Cancer submission deadline 15 May 2024 | 7 articles | Viewed by 9402 | Submission Open
Keywords: estradiol; progesterone; calcitriol; androgen; resveratrol; phytoestrogens; therapeutic targets; fulvestrant; treatment response; SERM; estrogen receptor isoforms; selective ligands; hormonal carcinogenesis; breast cancer prevention; hormone signaling; endocrine disruptor compounds; ER-negative breast cancer; ER-positive breast cancer; aromatase inhibitors
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Cellular Crosstalk in the Tumor Microenvironment submission deadline 15 May 2024 | 4 articles | Viewed by 9129 | Submission Open
Keywords: cancer; metastasis; inflammation; cancer-associated fibroblasts; biomarkers; multiplex imaging; in vitro models; animal models; immunotherapy
(This special issue belongs to the Section Biochemistry)
Therapeutic Modulation of Mesenchymal Stem Cell for Effective Regenerative Medicine
edited by
submission deadline 15 May 2024 | 5 articles | Viewed by 8593 | Submission Open
Keywords: stem cells; cell senescence; stem cell differentiation; adipogenesis; osteogenesis; cardiogenesis; conditioned media; epigenetics; biomarkers; cell-based therapies; malignant transformation
(This special issue belongs to the Section Molecular Biology)
Advances in Melanoma and Skin Cancers
edited by , and Maria Grazia Vitale
submission deadline 15 May 2024 | 6 articles | Viewed by 8484 | Submission Open
Keywords: melanoma; immunotherapy; biomarkers; translational research; drug repurposing; prognostic markers; predictive markers; combination immunotherapy
(This special issue belongs to the Section Molecular Oncology)
New Agents and Novel Drugs Use for the Oncological Diseases Treatment submission deadline 15 May 2024 | 8 articles | Viewed by 8483 | Submission Open
Keywords: anti-proliferative; cancer; molecular oncology; novel agents; off-label use; target therapy
(This special issue belongs to the Section Molecular Pharmacology)
Novel Therapeutic Targets of Solid Cancer
edited by
submission deadline 15 May 2024 | 5 articles | Viewed by 8148 | Submission Open
Keywords: cancer; signal transduction; kinase inhibitors; targeted therapy; precision medicine; drug resistance; survival; cell cycle; cell reprogramming; stem cells; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Latest Advances on Nanoparticles for Modern Biomedicine submission deadline 15 May 2024 | 8 articles | Viewed by 8119 | Submission Open
Keywords: nanomedicine; nanotechnology; cancer; nanotheranostics; targeted therapy; laser-ablative synthesis; drug delivery; imaging
(This special issue belongs to the Section Molecular Nanoscience)
Application of Nanostructures in Biology and Medicine
edited by
submission deadline 15 May 2024 | 4 articles | Viewed by 8103 | Submission Open
Keywords: materials science; synthetic biology; biotechnology; cell biology; metagenomics; bioimaging; nanostructures; nanodevices; green nanotechnology
(This special issue belongs to the Section Molecular Nanoscience)
Plant Response to Insects and Microbes 2.0
edited by
submission deadline 15 May 2024 | 7 articles | Viewed by 7644 | Submission Open
Keywords: plants; defense response; arthropods; bacteria; fungi; viruses; biotic stress
(This special issue belongs to the Section Molecular Plant Sciences)
Systemic and Mucosal Inflammation in Colorectal Cancer: Underlying Factors, Significance, and Related Biomarkers
edited by
submission deadline 15 May 2024 | 5 articles | Viewed by 6811 | Submission Open
Keywords: molecular changes; colorectal cancer; normal mucosa; apoptotic proteins; inflammatory mechanism; adenoma– carcinoma sequence; cancer biomarkers
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms of Plant Defense against Abiotic Stress 2.0
edited by
submission deadline 15 May 2024 | 5 articles | Viewed by 6751 | Submission Open
Keywords: abiotic stress; antioxidant activity; chlorophyll fluorescence; environmental pollution; photosynthesis; photosynthetic machinery; plant responses; plant tolerance; reactive oxygen species; thylakoid membranes; photosynthetic machinery; signal molecules
(This special issue belongs to the Section Molecular Plant Sciences)
Inflammation in Skin and Joints submission deadline 15 May 2024 | 4 articles | Viewed by 6675 | Submission Open
Keywords: inflammatory skin conditions; inflammation in joints; psoriasis; psoriatic arthritis; rheumatoid arthritis; collagen-induced arthritis; dermatitis; barrier function; angiogenesis; keratinocytes; inflammatory cells; immune cells
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Molecular Research on Autoimmune Diseases
edited by
submission deadline 15 May 2024 | 6 articles | Viewed by 6661 | Submission Open
Keywords: autoimmune markers; immunology; pathogenesis; immunogenetics; animal models; immunotherapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Sjögren's Syndrome 3.0 submission deadline 15 May 2024 | 5 articles | Viewed by 6505 | Submission Open
Keywords: autoimmunity; Sjö gren’ s syndrome; autoantibodies; salivary gland; lacrimal gland; dry eyes/mouth  
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Gastrointestinal Diseases: Molecular Mechanism, Diagnostics, and Novel Therapeutic Approaches
edited by
submission deadline 15 May 2024 | 6 articles | Viewed by 6401 | Submission Open
Keywords: gut microbiota; gut– brain axis; drug metabolism; drug delivery systems; drug resistance; gut barrier function; gut hormones; intestinal permeability; molecular diagnostics; biomarkers; molecular genetic profiling; molecular imaging modalities; molecular therapeutic targets; nanomedicine; molecular immunotherapy; molecular basis of immune response; molecular gene therapy; molecular mechanisms; genomics/epigenomics; next-generation sequencing; tumor microenvironment; DNA repair/methylation; animal models; signaling pathway
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Types of Antimicrobial Biocides
edited by
submission deadline 15 May 2024 | 6 articles | Viewed by 6400 | Submission Open
Keywords: biocides; pathogen; cross-resistance; infection
(This special issue belongs to the Section Molecular Pharmacology)
The Zebrafish Model in Animal and Human Health Research submission deadline 15 May 2024 | 5 articles | Viewed by 6228 | Submission Open
Keywords: zebrafish; environmental toxicology; predictive toxicology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Technology Advance and Application of Cryo-Electron Microscopy in Molecular Biology and Biomedicine
edited by and Jesús Gerardo Galaz-Montoya
submission deadline 15 May 2024 | 2 articles | Viewed by 6020 | Submission Open
Keywords: cryo-electron microscopy (cryo-EM)  ; cryo-electron tomography (cryo-ET)  ; cryo-EM sample preparation  ; single-particle analysis  ; sub-tomogram averaging  ; structural determination  ; molecular machines  ; structural dynamics  ; structure-based drug discovery  ; machine learning  ; conformational states  ; conformational landscape  ; conformational continuum  ; time-resolved cryo-EM  ; atomic modeling
(This special issue belongs to the Section Molecular Biophysics)
Hepatocellular Carcinoma in 2023: What Is New on Pathogenesis, Diagnosis and Treatment submission deadline 15 May 2024 | 2 articles | Viewed by 5771 | Submission Open
Keywords: liver cancer; hepatocellular carcinoma; hepatitis B virus; hepatitis C virus; nonalcoholic fatty liver disease; HBV; HCV; HCC; NAFLD; tumor microenvironment; gut liver axis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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