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Innovative Biomaterial Solutions for Translational Tissue Engineering and Regenerative Medicine
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Innovative Biomaterial Solutions for Translational Tissue Engineering and Regenerative Medicine

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: closed (31 December 2019) | Viewed by 11702

Special Issue Editor

Prof. Dr. Ziyad S. Haidar

E-Mail Website1 Website2
Guest Editor
1. Professor and Director of BioMAT’X R&D&I Group, Scientific Director—Research, Development and Innovation, Faculty of Dentistry, Universidad de los Andes, Santiago, Chile
2. Cross Appointment—BioMedicine Doctoral Program, Faculty of Medicine, Universidad de los Andes, Santiago, Chile
Interests: patient-oriented development and evaluation of bionanotechnology; biopolymers; bioceramics and drug delivery systems for the repair; restoration, reconstruction and regeneration of challenging craniofacial and orthopaedic defects
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues.

It is my privilege to invite you to submit a manuscript for an upcoming Special Issue of the Journal of Functional Biomaterials, entitled “Innovative Biomaterial Solutions for Translational Tissue Engineering and Regenerative Medicine”.

Innovative tissue engineering and regenerative medicine solutions that incorporate nanobiotechnology, advanced biomaterials, computer assistance, three-dimensional printing, and robotic systems offer extensive potential for augmenting and improving the functional and esthetic cranio-maxillo-facial and oro-dental health profile of patients.

A good example, perhaps, is nanodentistry, clearly multidisciplinary and interdisciplinary, building on existing knowledge and accruing expertise in different scientific and technological fields, seeking persistent refinement of traditional approaches, via the development and/or incorporation of advanced functional biomaterials, cell-/gene-/drug-delivery systems, new tools, and pharmacological formulations to improve overall oro-dental practice and care, which is slowly-evolving yet expected to provide dentists with more precision-made and tailored materials, drugs, and equipment, by which safety, esthetics, function, and patient compliance are enhanced. Due to the complex nature of such “outside-the-box” oro-dental and cranio-maxillo-facial (head and neck) healthcare-related engineering technologies, they have attracted experts from physics, chemistry, biology, materials science, pharmaceutics, robotics, and bioengineering, as well as industry.

This Special Issue is dedicated to the state-of-the-art in oro-dental and cranio-maxillo-facial tissue engineering (restoration, replacement, reconstruction, regeneration and repair)-related topics and emphasizes the bionanotechnology-, functional biomaterial-, and three-dimensional-related topics for innovative alternative solution design, characterization, evaluation and optimization. Hence, the focus is on demonstrating physico-chemico-mechanical/rheological, cellular, histomorphometrical and immunohistochemical parameters and safety (cyto-/bio-compatibility) and efficacy (pre-clinical and clinical) characteristics of functional biomaterials for tissue engineering and regenerative medicine.

Through a collection of original papers, this Special Issue aims to exhibit the latest state-of-the-art in R&D&i ideas, concepts, findings, achievements, and future projections and promote awareness of this rapidly-evolving and enabling multidisciplinary technology, thereby encouraging bridging the gap between medicine, dentistry, pharmacy, material sciences and engineering (including sub-specialities, extending to the head and neck, orthopaedics, oncology, amongst others) for research collaboration across the fields to address the critical and urgent bio-dental/bio-medical concerns. Clinicians and researchers are invited to contribute with their original evidence-based articles, as well as critical literature review manuscripts, summarizing the most recent and exciting innovative developments.

Potential topics include, but are not limited to, the following:

  • Biomimetic nanobiomaterials
  • Bioceramics and bioglasses
  • Exosomes and multi-vesicular bodies as drug carriers and delivery vehicles
  • Functional scaffolds for craniomaxillofacial tissue engineering applications
  • Stimuli-responsive biomaterials for tissue engineering
  • Smart and multifunctional biomaterials for tissue engineering
  • Functional biomaterials and cell/tissue–material interactions
  • Natural polymer-based biomaterials for tissue engineering
  • Nanodentistry and the role of nanobiotechnology in biomaterials, pharmaceutics, and biodental tissue engineering
  • Image-guided surgery and medico-dental robotics
  • 3-D printing and surgical engineering in the craniomaxillofacial complex
  • Computer-aided planning and intraoperative navigation in dental implantology and craniomaxillofacial surgery
  • Biomaterial fabrication and evaluation techniques: freeze drying, electrospinning, etc.
  • Drug/Gene delivery and Cell therapy
  • Injectable biomaterials for pharmaceutic agent (cell, gene, drug) delivery
  • Cosmetology and orofacial surgery
  • Microfabrication approaches for engineering functional tissues
  • Platelet concentrates and platelet-rich fibrin for tissue repair
  • Translational functional biomaterials: bench-top to bed-side/market

You may choose our Joint Special Issue in Materials.

Prof. Dr. Ziyad S. Haidar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tissue engineering
  • regenerative medicine
  • bionanotechnology
  • biopolymers
  • bioceramics
  • drug delivery
  • restoration
  • orthopaedic

Published Papers (2 papers)

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Research

12 pages, 2940 KiB  
Article
Coating Medpor® Implant with Tissue-Engineered Elastic Cartilage
by Dong Joon Lee, Jane Kwon, Yong-Il Kim, Yong Hoon Kwon, Samuel Min and Hae Won Shin
J. Funct. Biomater. 2020, 11(2), 34; https://doi.org/10.3390/jfb11020034 - 22 May 2020
Cited by 6 | Viewed by 4445
Abstract
Inert biomaterials used for auricular reconstruction, which is one of the most challenging and diverse tasks in craniofacial or head and neck surgery, often cause problems such as capsule formation, infection, and skin extrusion. To solve these problems, scaffold consisting of inert biomaterial, [...] Read more.
Inert biomaterials used for auricular reconstruction, which is one of the most challenging and diverse tasks in craniofacial or head and neck surgery, often cause problems such as capsule formation, infection, and skin extrusion. To solve these problems, scaffold consisting of inert biomaterial, high-density polyethylene (Medpor®) encapsulated with neocartilage, biodegradable poly(DL-lactic-co-glycolic acid) (PLGA) was created using a tissue engineering strategy. PLGA scaffold without Medpor® was created to serve as the control. Scaffolds were vacuum-seeded with rabbit chondrocytes, freshly isolated from the ear by enzymatic digestion. Then, cell-seeded scaffolds were implanted subcutaneously in the dorsal pockets of nude mice. After 12 weeks, explants were analyzed by histological, biochemical, and mechanical evaluations. Although the PLGA group resulted in neocartilage formation, the PLGA–Medpor® group demonstrated improved outcome with the formation of well-surrounded cartilage around the implants with higher mechanical strength than the PLGA group, indicating that Medpor® has an influence on the structural strength of engineered cartilage. The presence of collagen and elastin fibers was evident in the histological section in both groups. These results demonstrated a novel method of coating implant material with engineered cartilage to overcome the limitations of using biodegradable scaffold in cartilage tissue regeneration. By utilizing the patient’s own chondrocytes, our proposed method may broaden the choice of implant materials while minimizing side effects and immune reaction for the future medical application. Full article
(This article belongs to the Special Issue Innovative Biomaterial Solutions for Translational Tissue Engineering and Regenerative Medicine)
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9 pages, 1770 KiB  
Article
Repair of Orbital Post-Traumatic Wall Defects by Custom-Made TiNi Mesh Endografts
by Valentin Shtin, Valeriy Novikov, Timofey Chekalkin, Victor Gunther, Ekaterina Marchenko, Evgeniy Choynzonov, Seung Baik Kang, Moon Jong Chang, Ji Hoon Kang and Aleksei Obrosov
J. Funct. Biomater. 2019, 10(3), 27; https://doi.org/10.3390/jfb10030027 - 27 Jun 2019
Cited by 16 | Viewed by 6674
Abstract
Repairs of orbital post-traumatic and extensive malignant defects remain a major surgical challenge, in view of follow-up outcomes. Incorrect surgical management of injured facial structures results in cosmetic, ophthalmic, and social aftereffects. A custom-made knitted TiNi-based mesh (KTNM) endograft was employed to overcome [...] Read more.
Repairs of orbital post-traumatic and extensive malignant defects remain a major surgical challenge, in view of follow-up outcomes. Incorrect surgical management of injured facial structures results in cosmetic, ophthalmic, and social aftereffects. A custom-made knitted TiNi-based mesh (KTNM) endograft was employed to overcome post-surgical complications and post-resected lesions of the orbital area. Preoperative high-resolution computed tomography (CT) imaging and CAD modelling were used to design the customized KTNM in each case. Twenty-five patients underwent surgery utilizing the suggested technique, from 2014 to 2019. In all documented cases, resolution of the ophthalmic malfunction was noted in the early period. Follow-up observation evidenced no relapsed enophthalmos, hypoglobus, or diplopia as late complications. The findings emanating from our clinical observations allow us to claim that the KTNM indicated a high level of biocompatibility. It is simply modified intraoperatively to attach any desired shape/size for implantation and can also be screw-fixed, providing a good supporting ability. The KTNM precisely renders orbitozygomatic outlines and orbital floor, thus recovering the anatomical structure, and is regarded as an attractive alternative to Ti-based meshes and plates. Additionally, we report one of the studied cases, where good functional and cosmetic outcomes have been achieved. Full article
(This article belongs to the Special Issue Innovative Biomaterial Solutions for Translational Tissue Engineering and Regenerative Medicine)
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