Topic Editors

Department of Biomedical Engineering, University of Bridgeport, Bridgeport, CT 06604, USA
1. Founder and Director of BioMAT’X R&D&I (HAiDAR I+D+i )LABs, Las Condes, Santiago, Chile
2. Professor and Scientific Director—Research, Development and Innovation, Faculty of Dentistry, Universidad de los Andes, Santiago, Chile
3. Professor, Dental Sciences Doctoral Program, Faculty of Dentistry, Universidad de los Andes, Santiago, Chile
4. Professor, CiiB, BioMedicine Doctoral Program, Faculty of Medicine, Universidad de los Andes, Santiago, Chile

Injectable Hydrogels for Cell and Drug Delivery

Abstract submission deadline
30 April 2025
Manuscript submission deadline
30 June 2025
Viewed by
1943

Topic Information

Dear Colleagues,

Most cells and drugs require appropriate formulation for their successful application as pharmaceuticals. The use of polymer-based hydrogel biomaterials for the delivery of drugs and recruitment of cells to promote tissue regeneration in the body is of growing interest. This Topic will invite original research and review articles focusing primarily on the principles and strategies employed for the design, formulation, characterization, evaluation, and translation of novel injectable hydrogels for pharmaceuticals and tissue engineering applications. It will accomplish this by discussing and/or presenting recent innovative advances in polymers, their building blocks, and the engineering chemistries for their formation, whether by chemical crosslinking reactions or physical interactions. Potential topics include, but are not limited to, the following:

  • drug delivery hydrogels
  • pharmacokinetics in hydrogels
  • stimuli-responsive polymers
  • natural polymers
  • hydrogel nanoparticles
  • injectable hydrogels
  • drug encapsulation
  • dynamic hydrogels
  • sustained drug release
  • targeted drug delivery

Dr. Prabir Patra
Prof. Dr. Ziyad S. Haidar
Topic Editors

Keywords

  • injectable
  • hydrogels
  • therapeutics
  • agent delivery
  • cell
  • drug delivery
  • crosslinking reaction
  • tissue repair and regeneration
  • pharmaceuticals
  • natural polymer
  • synthetic polymer
  • peptide
  • polysaccharides

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Cells
cells
5.1 9.9 2012 17.5 Days CHF 2700 Submit
Materials
materials
3.1 5.8 2008 15.5 Days CHF 2600 Submit
Molecules
molecules
4.2 7.4 1996 15.1 Days CHF 2700 Submit
Pharmaceutics
pharmaceutics
4.9 7.9 2009 14.9 Days CHF 2900 Submit
Separations
separations
2.5 3.0 2014 12.4 Days CHF 2600 Submit

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Published Papers (1 paper)

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15 pages, 1446 KiB  
Article
Efficient Hydroxyapatite Extraction from Salmon Bone Waste: An Improved Lab-Scaled Physico-Chemico-Biological Process
by Francisco Muñoz, Ziyad S. Haidar, Andreu Puigdollers, Ignacio Guerra, María Cristina Padilla, Nicole Ortega, Mercedes Balcells and María José García
Molecules 2024, 29(17), 4002; https://doi.org/10.3390/molecules29174002 - 24 Aug 2024
Cited by 1 | Viewed by 804
Abstract
The demand for novel tissue grafting and regenerative wound care biomaterials is growing as traditional options often fall short in biocompatibility, functional integration with human tissue, associated cost(s), and sustainability. Salmon aquaculture generates significant volumes of waste, offering a sustainable opportunity for biomaterial [...] Read more.
The demand for novel tissue grafting and regenerative wound care biomaterials is growing as traditional options often fall short in biocompatibility, functional integration with human tissue, associated cost(s), and sustainability. Salmon aquaculture generates significant volumes of waste, offering a sustainable opportunity for biomaterial production, particularly in osteo-conduction/-induction, and de novo clinical/surgical bone regeneration. Henceforth, this study explores re-purposing salmon waste through a standardized pre-treatment process that minimizes the biological waste content, followed by a treatment stage to remove proteins, lipids, and other compounds, resulting in a mineral-rich substrate. Herein, we examined various methods—alkaline hydrolysis, calcination, and NaOH hydrolysis—to better identify and determine the most efficient and effective process for producing bio-functional nano-sized hydroxyapatite. Through comprehensive chemical, physical, and biological assessments, including Raman spectroscopy and X-ray diffraction, we also optimized the extraction process. Our modified and innovative alkaline hydrolysis–calcination method yielded salmon-derived hydroxyapatite with a highly crystalline structure, an optimal Ca/P ratio, and excellent biocompatibility. The attractive nano-scale cellular/tissular properties and favorable molecular characteristics, particularly well-suited for bone repair, are comparable to or even surpass those of synthetic, human, bovine, and porcine hydroxyapatite, positioning it as a promising candidate for use in tissue engineering, wound healing, and regenerative medicine indications. Full article
(This article belongs to the Topic Injectable Hydrogels for Cell and Drug Delivery)
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