Impact of Exercise on Energy and Muscle Metabolism

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Cell Metabolism".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 1551

Special Issue Editor


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Guest Editor
Department for the Biosciences of Sports, Institute of Sports Science, University of Hildesheim, Hildesheim, Germany
Interests: skeletal muscle; exercise; energy metabolism; muscle growth and damage; cell signaling in skeletal muscle; mitochondrial adaptation; metabolism and exercise adaptation
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Special Issue Information

Dear Colleagues,

This Special Issue focuses on exploring the intricate relationship between exercise, energy metabolism, and muscle physiology and its adaptation. Exercise has long been known to have a significant impact on these areas, and recent research has unveiled the underlying mechanisms and their implications for human health and performance.

This Special Issue features a collection of studies that investigate various aspects of this topic. These studies delve into the effects of different types of exercise regimens on energy expenditure, substrate utilization, metabolic pathways, skeletal muscle and exercise adaptation. Researchers have employed advanced techniques, such as metabolomics, proteomics and isotopic tracing, to uncover how exercise influences the way our bodies produce, utilize, and store energy within skeletal muscle and how this affects exercise performance and adaptation.

A key theme in this Special Issue is the adaptability of muscle metabolism in response to exercise and how this acutely and chronically affects muscle performance and adaptation. Studies have examined the molecular and cellular changes that occur in muscle tissue during and after exercise, shedding light on how exercise impacts mitochondrial function, oxidative stress and muscle fiber composition. Additionally, this Special Issue aims to explore the interplay between exercise-induced muscle contractions and metabolic signaling pathways, revealing insights into how these interactions contribute to overall metabolic health.

Prof. Dr. Sebastian Gehlert
Guest Editor

Manuscript Submission Information

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Keywords

  • muscle fibers
  • exercise metabolism
  • skeletal muscle adaptation
  • exercise performance
  • mitochondrial adaptation
  • exercise intensity and skeletal muscle metabolism
  • nutrition and exercise metabolism

Published Papers (1 paper)

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Review

17 pages, 1803 KiB  
Review
Roles of Myokines and Muscle-Derived Extracellular Vesicles in Musculoskeletal Deterioration under Disuse Conditions
by Jie Zhang, Yunfang Gao and Jiangwei Yan
Metabolites 2024, 14(2), 88; https://doi.org/10.3390/metabo14020088 - 26 Jan 2024
Viewed by 1302
Abstract
Prolonged inactivity and disuse conditions, such as those experienced during spaceflight and prolonged bedrest, are frequently accompanied by detrimental effects on the motor system, including skeletal muscle atrophy and bone loss, which greatly increase the risk of osteoporosis and fractures. Moreover, the decrease [...] Read more.
Prolonged inactivity and disuse conditions, such as those experienced during spaceflight and prolonged bedrest, are frequently accompanied by detrimental effects on the motor system, including skeletal muscle atrophy and bone loss, which greatly increase the risk of osteoporosis and fractures. Moreover, the decrease in glucose and lipid utilization in skeletal muscles, a consequence of muscle atrophy, also contributes to the development of metabolic syndrome. Clarifying the mechanisms involved in disuse-induced musculoskeletal deterioration is important, providing therapeutic targets and a scientific foundation for the treatment of musculoskeletal disorders under disuse conditions. Skeletal muscle, as a powerful endocrine organ, participates in the regulation of physiological and biochemical functions of local or distal tissues and organs, including itself, in endocrine, autocrine, or paracrine manners. As a motor organ adjacent to muscle, bone tissue exhibits a relative lag in degenerative changes compared to skeletal muscle under disuse conditions. Based on this phenomenon, roles and mechanisms involved in the communication between skeletal muscle and bone, especially from muscle to bone, under disuse conditions have attracted widespread attention. In this review, we summarize the roles and regulatory mechanisms of muscle-derived myokines and extracellular vesicles (EVs) in the occurrence of muscle atrophy and bone loss under disuse conditions, as well as discuss future perspectives based on existing research. Full article
(This article belongs to the Special Issue Impact of Exercise on Energy and Muscle Metabolism)
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