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Micromachines
Special Issues
Micro-, Nano-Fluidics and Biosensors in Food Safety Applications
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Micro-, Nano-Fluidics and Biosensors in Food Safety Applications

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 12288

Special Issue Editors

Prof. Dr. Dang Duong Bang

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Guest Editor
Laboratory of Applied Micro and Nanotechnology (LAMINATE), Research Group for Microbiology and Hygien, Division of Microbiology and Production, National Food Institute, Technical University of Denmark, Kemitorvet, Building 204 Room 214, DK 2800 Lyngby, Denmark
Interests: foodborne diseases; total-integrated system; lab-on-chip; clinical diagnosis; DNA, RNA applification
Special Issues, Collections and Topics in MDPI journals
Dr. Vinayaka Aaydha Chidambara

E-Mail Website
Guest Editor
Laboratory of Applied Micro and Nanotechnology (LAMINATE), Research group for Microbiology and Hygien, Division of Microbiology and Production, National Food Institute, Danmarks Tekniske Universitet, Lyngby, Denmark
Interests: biosensors; immunosensors; aptamers; on-site testing; food safety; foodborne pathogens; rapid diagnostics
Dr. Trieu Nguyen

E-Mail Website
Guest Editor
Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, California Northstate University, Elk Grove, CA 95757, USA
Interests: point of care diagnostics; lab-on-a-chip; microfluidics; organs-on-chip
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

According to the first ever estimates of the global burden of foodborne diseases from the World Health Organization (WHO) in December 2015, globally every year almost 1 in 10 people falls ill from eating contaminated food and 420,000 die as a result. Foodborne illnesses not only cause health concerns but are also responsible for economic losses worth billions of dollars worldwide due to the direct costs of treatment and others relevant costs such as personal transportation and ability to work. In order to lower and work towards to the elimination of the probability of foodborne illnesses, the rapid and effective detection of foodborne pathogens is vital. The development of science and technology in last two decades, especially in micro and nanofabrication and the material sciences has opened an opportunity for the rapid detection of low concentrations and low volumes of reagents, giving rise to applications and implementation in the detection of foodborne pathogens. We will primarily focus on the current developments and working principles of rapid detection methods and integrated devices both on-chip and off-chip for foodborne pathogens. The emphasis will be on point-of-care devices and online monitoring, which are currently drawing most of the scientific and industrial attention towards implementation for both the rapid detection and treatment of foodborne pathogens.

Prof. Dang Duong Bang
Dr. Vinayaka Aaydha Chidambara
Dr. Trieu Nguyen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Lab-on-a-chip
  • Microfluidics
  • Microfabrication
  • Nanofluidics
  • Food safety
  • Foodborne diseases
  • Pathogens
  • Point-of-care
  • Rapid detection
  • Treatment
  • Biosensors
  • Sample preparation

Published Papers (3 papers)

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Research

8 pages, 1989 KiB  
Article
An Origami Paper-Based Analytical Device for Rapid and Sensitive Analysis of Acrylamide in Foods
by Yu Yan, Dan Zhao, Weiming Li, Xiaoqian Li, Yangyang Chang, Qiang Zhang and Meng Liu
Micromachines 2022, 13(1), 13; https://doi.org/10.3390/mi13010013 - 23 Dec 2021
Cited by 8 | Viewed by 2825
Abstract
Rapid and sensitive detection of acrylamide in food samples is important for food safety and public health. Here, we describe a disposable origami paper-based analytical device (denoted doPAD) for colorimetric detection of acrylamide. This device uniquely exploits 3D origami folding paper for spatial [...] Read more.
Rapid and sensitive detection of acrylamide in food samples is important for food safety and public health. Here, we describe a disposable origami paper-based analytical device (denoted doPAD) for colorimetric detection of acrylamide. This device uniquely exploits 3D origami folding paper for spatial control of the target recognition and signal readout, thus resulting in a positive correlation between the signals and the analytes. Under optimal conditions, the device achieved the quantitative analysis of acrylamide with a limit of detection of 1.13 μg/L within 120 min (including a derivatization time of 90 min and an assay time of 21 min). Furthermore, our method allowed the rapid and sensitive detection of acrylamide in complex food matrices. We envision that the platform described will find useful applications in the fields of food safety and environmental health. Full article
(This article belongs to the Special Issue Micro-, Nano-Fluidics and Biosensors in Food Safety Applications)
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17 pages, 3869 KiB  
Article
A Fluidics-Based Biosensor to Detect and Characterize Inhibition Patterns of Organophosphate to Acetylcholinesterase in Food Materials
by Dang Song Pham, Xuan Anh Nguyen, Paul Marsh, Sung Sik Chu, Michael P. H. Lau, Anh H. Nguyen and Hung Cao
Micromachines 2021, 12(4), 397; https://doi.org/10.3390/mi12040397 - 3 Apr 2021
Cited by 2 | Viewed by 3382
Abstract
A chip-based electrochemical biosensor is developed herein for the detection of organophosphate (OP) in food materials. The principle of the sensing platform is based on the inhibition of dimethoate (DMT), a typical OP that specifically inhibits acetylcholinesterase (AChE) activity. Carbon nanotube-modified gold electrodes [...] Read more.
A chip-based electrochemical biosensor is developed herein for the detection of organophosphate (OP) in food materials. The principle of the sensing platform is based on the inhibition of dimethoate (DMT), a typical OP that specifically inhibits acetylcholinesterase (AChE) activity. Carbon nanotube-modified gold electrodes functionalized with polydiallyldimethylammonium chloride (PDDA) and oxidized nanocellulose (NC) were investigated for the sensing of OP, yielding high sensitivity. Compared with noncovalent adsorption and deposition in bovine serum albumin, bioconjugation with lysine side chain activation allowed the enzyme to be stable over three weeks at room temperature. The total amount of AChE was quantified, whose activity inhibition was highly linear with respect to DMT concentration. Increased incubation times and/or DMT concentration decreased current flow. The composite electrode showed a sensitivity 4.8-times higher than that of the bare gold electrode. The biosensor was challenged with organophosphate-spiked food samples and showed a limit of detection (LOD) of DMT at 4.1 nM, with a limit of quantification (LOQ) at 12.6 nM, in the linear range of 10 nM to 1000 nM. Such performance infers significant potential for the use of this system in the detection of organophosphates in real samples. Full article
(This article belongs to the Special Issue Micro-, Nano-Fluidics and Biosensors in Food Safety Applications)
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12 pages, 9291 KiB  
Article
A Complete Protocol for Rapid and Low-Cost Fabrication of Polymer Microfluidic Chips Containing Three-Dimensional Microstructures Used in Point-of-Care Devices
by Trieu Nguyen, Aaydha Chidambara Vinayaka, Dang Duong Bang and Anders Wolff
Micromachines 2019, 10(9), 624; https://doi.org/10.3390/mi10090624 - 19 Sep 2019
Cited by 20 | Viewed by 5340
Abstract
This protocol provides insights into the rapid, low-cost, and largescale fabrication of polymer microfluidic chips containing three-dimensional microstructures used in point-of-care devices for applications such as detection of pathogens via molecular diagnostic methods. The details of the fabrication methods are described in this [...] Read more.
This protocol provides insights into the rapid, low-cost, and largescale fabrication of polymer microfluidic chips containing three-dimensional microstructures used in point-of-care devices for applications such as detection of pathogens via molecular diagnostic methods. The details of the fabrication methods are described in this paper. This study offers suggestions for researchers and experimentalists, both at university laboratories and in industrial companies, to prevent doom fabrication issues. For a demonstration of bio-application in point-of-care testing, the 3D microarrays fabricated are then employed in multiplexed detection of Salmonella (Salmonella Typhimurium and Salmonella Enteritidis), based on a molecular detection technique called solid-phase polymerase chain reaction (SP-PCR). Full article
(This article belongs to the Special Issue Micro-, Nano-Fluidics and Biosensors in Food Safety Applications)
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