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Micromachines
Special Issues
Immunoassay Platforms for Biomedical Detection
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Immunoassay Platforms for Biomedical Detection

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 810

Special Issue Editors

Dr. Jian Gu

E-Mail Website
Guest Editor
Center for Applied NanoBioscience and Medicine, Department of Basic Medical Sciences, The University of Arizona College of Medicine-Phoenix, Phoenix, AZ 85004, USA
Interests: immunoassay; lateral/vertical flow assays; nano/microfluidics; nano/microscale biosensors; biosensor system integration
Dr. Chao Wang

E-Mail Website
Guest Editor
School of Electrical, Computer and Energy Engineering, Biodesign Center for Molecular Design and Biomimetics, Arizona State University, Tempe, AZ 85281, USA
Interests: nanofabrication; nanophotonics; portable electronic detectors; nanopore sensors; infectious diseases

Special Issue Information

Dear Colleagues,

This special issue of Micromachines, titled “Immunoassay Platforms for Biomedical Detection”, hopes to cover all aspects of the immunoassay for biomedical applications. Immunoassays have been explored and implemented for the detection of specific biological agents and markers for a wide ranges of biomedical applications, including point-of-care testings for emerging infectious diseases, health monitoring both on earth and in space, disease management and personalized medicine, screening and monitoring of allergies and drug abuse, food and water safety control, etc. Development of immunoassays has moved towards the rapid, sensitivive and multiplexed detection of biomarkers at higher throughput levels and at a lower cost or using low-resource settings. In this Special Issue, we invite full research papers, review articles and communications to showcase the recent innovations in immunoassay novel materials/structures for signal transduction, assay designs, device fabrication, sensing theories and simulation, reader technologies and system integration, as well as their applications in biomedical fields.

Dr. Jian Gu
Dr. Chao Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • immunoassay
  • lateral/vertical flow assays
  • nano/microfluidics
  • nano/microscale biosensors
  • biosensor system integration
  • lab-on-a-chip
  • point-of-care testing
  • healthcare and environmental monitoring

Published Papers (1 paper)

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Research

13 pages, 3513 KiB  
Article
On reactive Ion Etching of Parylene-C with Simple Photoresist Mask for Fabrication of High Porosity Membranes to Capture Circulating and Exfoliated Tumor Cells
by Inad Rabadi, David Carpentieri, Jue Wang, Frederic Zenhausern and Jian Gu
Micromachines 2024, 15(4), 521; https://doi.org/10.3390/mi15040521 - 13 Apr 2024
Viewed by 431
Abstract
A high porosity micropore arrayed parylene membrane is a promising device that is used to capture circulating and exfoliated tumor cells (CTCs and ETCs) for liquid biopsy applications. However, its fabrication still requires either expensive equipment or an expensive process. Here, we report [...] Read more.
A high porosity micropore arrayed parylene membrane is a promising device that is used to capture circulating and exfoliated tumor cells (CTCs and ETCs) for liquid biopsy applications. However, its fabrication still requires either expensive equipment or an expensive process. Here, we report on the fabrication of high porosity (>40%) micropore arrayed parylene membranes through a simple reactive ion etching (RIE) that uses photoresist as the etching mask. Vertical sidewalls were observed in etched parylene pores despite the sloped photoresist mask sidewalls, which was found to be due to the simultaneous high DC-bias RIE induced photoresist melting and substrate pedestal formation. A theoretical model has been derived to illustrate the dependence of the maximum membrane thickness on the final pore-to-pore spacing, and it is consistent with the experimental data. A simple, yet accurate, low number (<50) cell counting method was demonstrated through counting cells directly inside a pipette tip under phase-contrast microscope. Membranes as thin as 3 μm showed utility for low number tumor cell capture, with an efficiency of 87–92%. Full article
(This article belongs to the Special Issue Immunoassay Platforms for Biomedical Detection)
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