Dear Colleagues,

This Special Issue is entitled “Medicinal Chemistry in Europe”. In Europe, many research groups, both from industry and academia, are working on medicinal chemistry topics that cover almost all therapeutic fields, ranging from anticancer and antimicrobial agents to compounds potentially active in severe cerebral pathologies, including Parkinson’s and Alzheimer’s diseases. Molecules devoted to the treatment of rare disease are also being investigated. The results obtained, frequently very important and recognized all over the world, are derived from the close collaboration of experts in different areas, such as computational chemistry, organic chemistry, biology, biochemistry and pharmacology.

Scientists from Europe are cordially invited to contribute original research papers or reviews to this Special Issue of Molecules, which reports on the design, synthesis, and evaluation of potentially-active compounds in the different subjects of medicinal chemistry.

Prof. Dr. Silvia Schenone
Guest Editor

* Silvia Schenone is a full professor of medicinal chemistry at the Pharmacy Department of the University of Genoa, Italy. She is involved in the design, synthesis and identification of organic molecules endowed with pharmacological activity. She is also interested in structural studies of biological macromolecules and molecular modeling applications in medicinal subjects. She started her work in the field of anti-inflammatory agents, then moved to adenosine receptor antagonists, and in the last few years she has been working on the design and synthesis of protein kinase inhibitors as anticancer agents. Her research on this last topic has led to the publication of 85 articles and four patents. Her other expertise is related to ADME (adsorption, distribution, metabolism and excretion) studies in silico, in vitro and in vivo. In many cases, to improve the bioavailability of the most active compounds, she has prepared and optimized different pharmaceutical formulations, including albumin nanoparticles, liposomes and cyclodextrine complexes. Recently, she has been involved in the synthesis of prodrugs which are particularly useful to improve the bioavailability of active compounds with poor water solubility, as in the case of the majority of protein kinase inhibitors. She collaborates with many groups of biologists and pharmacologists in Italy, Europe and USA. She is the author of 162 articles and of 6 patents.

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• drug discovery
• biologically active compounds
• anticancer agents
• antimicrobial agents
• analgesic and anti-inflammatory agents
• CNS pathologies
• rare diseases
• cardiovascular diseases

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