Special Issue "Click Chemistry"
Deadline for manuscript submissions: closed (31 July 2010)
Prof. Dr. Christian Girard (Website)
Unité de Technologies Chimiques & Biologiques pour la Santé, Equipe SEISAD - Synthèse Electrochimie, Imagerie et Systèmes Analytiques pour le Diagnostique, UMR 8258 CNRS / U 1022 INSERM, Ecole Nationale Supérieure de Chimie de Paris 11, rue P. & M. Curie, 75231 Paris cedex 05, France
Fax: +33-1 44 27 64 96
Click-chemistry is a new way of thinking molecular construction that emerges at the turn of this century. This concept, introduced by K. B. Sharpless, is based on the use of fast and efficient reactions between building blocks that opens the way to quasi-illimited variations in chemical architecture. Click-chemistry permits the construction of highly diversified structures through the use of reactive subunits, that can be joined using nucleophilic and electrophilic substitutions, ring opening reactions, cycloadditions reactions such as the copper (I)-modified Huisgen reaction and the Diels-Alder one, additions to unsaturated bonds, carbonyl chemistry, and so on. The scope of this new way of thinking molecular construction is large and has found many applications in classical organic synthesis, polymers and material sciences, as well as at the biological interface, with biocompatible conditions.
This Special Issue of Molecules has the objective to present articles that cover the use of click-chemistry to generate molecular diversity by organic synthesis (molecular libraries, chemical architecture, complexe structures, etc.), as well as its application at the frontier with other sciences.
Prof. Dr. Christian Girard
- organic synthesis
- molecular diversity
- interfaces with other sciences (pharmaceutical, biological, polymers, materials, etc.)