Bioactive Lipids and Metabolism Disease

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Lipids".

Deadline for manuscript submissions: 15 November 2024 | Viewed by 358

Special Issue Editors

School of Pharmacy, Jiangsu University, Zhenjiang 212013, China
Interests: functional foods; food chemistry; lipid metabolism; oxidative stress; antioxidation; lipid analysis; lipidomics
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Guest Editor
Department of Medicine, University of Padua, 35100 Padua, Italy
Interests: nutrition; epidemiology; diet; macro and micronutrients; lipids; hypertension; uric acid; cardiovascular risk factors; cardiovascular prevention; public health; obesity

Special Issue Information

Dear Colleagues,

I am pleased to announce the launch of the Special Issue of Nutrients entitled “Bioactive Lipids and Metabolism Disease”. The complex link between metabolic disorders and lipid metabolism necessitates a deeper understanding of how to regulate our bodies for optimal health through nutritional science. This Special Issue emphasizes the most recent research on bioactive lipids, their regulatory functions in metabolic pathways and potential applications in therapy, along with their intersection with nutritional science to enhance health outcomes.

By assembling this pioneering repository of knowledge, our objective is to connect the dots between lipid biochemistry, metabolic disease research, clinical applications and nutritional insights. We are particularly interested in submissions of original research articles and comprehensive reviews that explore the mechanisms through which bioactive lipids influence metabolic diseases. This includes their identification, functional analysis, interactions with dietary components and consequent effects on health outcomes. Studies elucidating the molecular pathways mediated by bioactive lipids, their contribution to disease prevention and management, and the innovation of lipid-based therapeutics, with an eye toward nutritional interventions, are highly encouraged.

We look forward to your valuable contributions.

Dr. Zhen Chen
Dr. Valerie Tikhonoff
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive lipids
  • functional food
  • cardiovascular health
  • metabolic syndrome
  • hypolipidemia
  • mitochondrial function
  • non-alcoholic fatty liver disease (NALFD)
  • obesity prevention
  • lipid therapeutics
  • molecular nutrition
  • dietary lipids and health

Published Papers (1 paper)

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Research

14 pages, 1589 KiB  
Article
Lipidomic Assessment of the Inhibitory Effect of Standardized Water Extract of Hydrangea serrata (Thunb.) Ser. Leaves during Adipogenesis
by Jae Sik Yu, Hee Ju Kim, Yeo Eun Kim, Hyun Ok Yang, Yu-Kyong Shin, Hyunjae Kim, Soyoon Park and Gakyung Lee
Nutrients 2024, 16(10), 1508; https://doi.org/10.3390/nu16101508 - 16 May 2024
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Abstract
Obesity is primarily exacerbated by excessive lipid accumulation during adipogenesis, with triacylglycerol (TG) as a major lipid marker. However, as the association between numerous lipid markers and various health conditions has recently been revealed, investigating the lipid metabolism in detail has become necessary. [...] Read more.
Obesity is primarily exacerbated by excessive lipid accumulation during adipogenesis, with triacylglycerol (TG) as a major lipid marker. However, as the association between numerous lipid markers and various health conditions has recently been revealed, investigating the lipid metabolism in detail has become necessary. This study investigates the lipid metabolic effects of Hydrangea serrata (Thunb.) Ser. hot water leaf extract (WHS) on adipogenesis using LC-MS-based lipidomics analysis of undifferentiated, differentiated, and WHS-treated differentiated 3T3-L1 cells. WHS treatment effectively suppressed the elevation of glycerolipids, including TG and DG, and prevented a molecular shift in fatty acyl composition towards long-chain unsaturated fatty acids. This shift also impacted glycerophospholipid metabolism. Additionally, WHS stabilized significant lipid markers such as the PC/PE and LPC/PE ratios, SM, and Cer, which are associated with obesity and related comorbidities. This study suggests that WHS could reduce obesity-related risk factors by regulating lipid markers during adipogenesis. This study is the first to assess the underlying lipidomic mechanisms of the adipogenesis-inhibitory effect of WHS, highlighting its potential in developing natural products for treating obesity and related conditions. Our study provides a new strategy for the development of natural products for the treatment of obesity and related diseases. Full article
(This article belongs to the Special Issue Bioactive Lipids and Metabolism Disease)
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