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Functional Foods and Health Promotion

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (25 March 2024) | Viewed by 5589

Special Issue Editors


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Guest Editor
Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Naples, NA, Italy
Interests: food supplements; functional food ingredients; polyphenols; biological activity; in vitro bioaccessibility and bioavailability
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Co-Guest Editor
Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Naples, Italy
Interests: polyphenols; nutrition; prevention; biology; bioavailability

Special Issue Information

Dear Colleagues,

According to the World Health Organization (WHO) Non communicable Diseases (NCDs), also known as chronic diseases, kill 41 million people each year representing 74% of all deaths globally. A disease is considered chronic when the patient conditions require medical treatment and symptoms last for a year or more. NCDs are the result of the combination of non-modifiable and modifiable risk factors, among which are included poor nutrition or diets with low fruits and vegetables intake.

In this perspective the research and the study of new functional food is becoming more and more important every year, considering that they can be used to reduce and especially prevent NCDs improving the outcomes of patients. The European Food Safety Authority (EFSA) defines functional as “a food, which beneficially affects one or more target functions in the body, beyond adequate nutritional effects, in a way that is relevant to either an improved state of health and well-being and/or reduction of risk of disease”.

This special issue, “Functional Foods and Health Promotion”, is focused on the identification, development, and establishment of functional foods through the study of the biological mechanisms that food bioactive components can express, improving the patient's state of health. Moreover, the research of alternative approaches capable of reducing the high cost of NCDs in the health care system through the promotion of control and prevention is becoming an essential and successful long-term strategy.

For all the reasons cited above a wide range of articles are welcome, including in vitro and in vivo studies, which are essential to obtain new data for the future clinical trials. A particular attention will be dedicated to clinical studies, considering their support by convincing scientific data to the efficacy of new functional food. Finally, comprehensive reviews which can summarize important topics useful for the birth of new scientific studies.

Dr. Hammad Ullah
Dr. Marco Dacrema
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polyphenols
  • health
  • functional food
  • prevention
  • reduction of risk disease

Published Papers (2 papers)

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Research

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17 pages, 5261 KiB  
Article
Eriocitrin Inhibits Angiogenesis by Targeting VEGFR2-Mediated PI3K/AKT/mTOR Signaling Pathways
by Ji-Yoon Baek, Jeong-Eun Kwak and Mok-Ryeon Ahn
Nutrients 2024, 16(7), 1091; https://doi.org/10.3390/nu16071091 - 8 Apr 2024
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Abstract
Eriocitrin, a flavanone found in peppermint and citrus fruits, is known to possess many physiological activities. However, the anti-angiogenic effects of eriocitrin are yet to be fully elucidated. Therefore, the objective of this research was to explore the anti-angiogenic effects of eriocitrin both [...] Read more.
Eriocitrin, a flavanone found in peppermint and citrus fruits, is known to possess many physiological activities. However, the anti-angiogenic effects of eriocitrin are yet to be fully elucidated. Therefore, the objective of this research was to explore the anti-angiogenic effects of eriocitrin both in vitro and in vivo as well as its underlying mechanism. Anti-angiogenic effects of eriocitrin were evaluated utilizing in vitro models of angiogenesis, including inhibition of tube formation, and induction of apoptosis in human umbilical vein endothelial cells (HUVECs). A chorioallantoic membrane (CAM) assay in chick embryos was also performed to evaluate the in vivo effects of eriocitrin on angiogenesis. Results showed significant eriocitrin effects on proliferation, tube formation, migration, and apoptosis in HUVECs. Furthermore, in vivo analysis revealed that eriocitrin significantly suppressed the formation of new blood vessels. In particular, it regulated MAPK/ERK signaling pathway and VEGFR2, inhibited the downstream PI3K/AKT/mTOR signaling pathway, and activated apoptosis signals such as caspase cascades. In HUVECs, the expression of matrix metalloproteinases (MMP-2 and MMP-9) exhibited an inhibitory effect on angiogenesis through the suppression of the signaling pathway. Therefore, eriocitrin presents potential for development into an antiangiogenic therapeutic agent. Full article
(This article belongs to the Special Issue Functional Foods and Health Promotion)
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Review

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18 pages, 985 KiB  
Review
Black Goji Berry (Lycium ruthenicum Murray): A Review of Its Pharmacological Activity
by Ho Seon Lee and Chang-Ik Choi
Nutrients 2023, 15(19), 4181; https://doi.org/10.3390/nu15194181 - 27 Sep 2023
Cited by 1 | Viewed by 4269
Abstract
Lycium ruthenicum Murray (LRM; commonly known as black goji berry or black wolfberry), a plant in the Solanaceae family, grows in the deserts of China’s Qinghai–Tibet plateau. LRM is widely consumed in traditional Chinese medicine, and its fruits are frequently used as herbal [...] Read more.
Lycium ruthenicum Murray (LRM; commonly known as black goji berry or black wolfberry), a plant in the Solanaceae family, grows in the deserts of China’s Qinghai–Tibet plateau. LRM is widely consumed in traditional Chinese medicine, and its fruits are frequently used as herbal remedies to treat heart disease, fatigue, inflammation, and other conditions. Many studies have reported that LRM is rich in functional phytochemicals, such as anthocyanins and polysaccharides, and has various pharmacological actions. This article reviews research on the biological and pharmacological effects of the constituents of LRM fruits. LRM has various pharmacological properties, such as antioxidant, anti-inflammatory, anti-radiation, immune-enhancing, anti-tumor, and protective effects. LRM has much promise as a dietary supplement for preventing many types of chronic metabolic disease. Full article
(This article belongs to the Special Issue Functional Foods and Health Promotion)
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