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The Benefits of Dietary Antioxidants on Immune Function

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Immunology".

Deadline for manuscript submissions: closed (31 January 2020) | Viewed by 3152

Special Issue Editor


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Guest Editor
Research Group on Community Nutrition & Oxidative Stress, Research Institute of Health Sciences (IUNICS), CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN CB12/03/30038) & Health Institute of the Balearic Islands (IDISBA), University of the Balearic Islands, Palma de Mallorca, Spain
Interests: human nutrition; obesity; clinical trials; adults; children
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Special Issue Information

Dear Colleagues,

Epidemiological studies have pointed out associations between dietary antioxidant and reduced incidence of several diseases, which have been related with a boost to the body's immune system, and antioxidants might, at least in part, account for this. There is also evidence that antioxidants are able to modify cell immune responses. The immune system is extremely sensitive to oxidative damage; and many immune cells produce reactive oxygen species as part of the body’s defence against infection and depend on adequate protection by antioxidants for optimal function. Many antioxidants can be obtained directly from the diet or require micronutrients as integral components of protective antioxidant enzymes. Indeed, it might be essential to have an adequate intake of antioxidant nutrients to improve immune function, but also to prevent the onset or the development of several degenerative diseases.

Prof. Dr. Josep A. Tur
Guest Editor

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Keywords

  • Dietary antioxidants 
  • Immune function 
  • Oxidative stress
  • Reactive oxygen species
  • Inflammation
  • Health

Published Papers (1 paper)

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Research

16 pages, 1062 KiB  
Article
Chronic Polyphenon-60 or Catechin Treatments Increase Brain Monoamines Syntheses and Hippocampal SIRT1 LEVELS Improving Cognition in Aged Rats
by Margarita R. Ramis, Fiorella Sarubbo, Silvia Tejada, Manuel Jiménez, Susana Esteban, Antoni Miralles and David Moranta
Nutrients 2020, 12(2), 326; https://doi.org/10.3390/nu12020326 - 26 Jan 2020
Cited by 21 | Viewed by 2489
Abstract
Polyphenolic compounds from green tea have great interest due to its large CONSUMPTION and therapeutic potential on the age-associated brain decline. The current work compares a similar dose regimen of a whole-green-tea extract and catechin in old rats over the course of 36 [...] Read more.
Polyphenolic compounds from green tea have great interest due to its large CONSUMPTION and therapeutic potential on the age-associated brain decline. The current work compares a similar dose regimen of a whole-green-tea extract and catechin in old rats over the course of 36 days. Results showed a significant improvement in visuo-spatial working memory and episodic memory of old rats after polyphenolic compounds administration assessed by behavioral tests. No effects were observed on the age-associated motor coordination decline. Statistically, results were correlated with significant improvements, mainly in hippocampal and striatal noradrenergic and serotonergic systems, but also with the striatal dopaminergic system. Both polyphenolic treatments also reverted the age-associated reduction of the neuroinflammation by modulating protein sirtuin 1 (SIRT1) expression in hippocampus, but no effects were observed in the usual reduction of the histone-binding protein RBAP46/48 protein linked to aging. These results are in line with previous ones obtained with other polyphenolic compounds, suggesting a general protective effect of all these compounds on the age-associated brain decline, pointing to a reduction of the oxidative stress and neuroinflammatory status reduction as the leading mechanisms. Results also reinforce the relevance of SIRT1-mediated mechanism on the neuroprotective effect and rule out the participation of RBAP46/48 protein. Full article
(This article belongs to the Special Issue The Benefits of Dietary Antioxidants on Immune Function)
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