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Antioxidants
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Oxidative/Inflammatory Determinants of Non-alcoholic Fatty Liver Disease: The Role of...
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Oxidative/Inflammatory Determinants of Non-alcoholic Fatty Liver Disease: The Role of Diet and Lifestyle

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (15 March 2024) | Viewed by 1693

Special Issue Editors

Dr. Cristina Bouzas

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Guest Editor
Research Group on Community Nutrition & Oxidative Stress, Research Institute of Health Sciences (IUNICS), CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN CB12/03/30038) & Health Institute of the Balearic Islands (IDISBA), University of the Balearic Islands, Palma de Mallorca, Spain
Interests: diet quality; metabolic syndrome; adults; food consumption
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Josep A. Tur

E-Mail Website
Guest Editor
Research Group on Community Nutrition & Oxidative Stress, Research Institute of Health Sciences (IUNICS), CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN CB12/03/30038) & Health Institute of the Balearic Islands (IDISBA), University of the Balearic Islands, Palma de Mallorca, Spain
Interests: human nutrition; obesity; clinical trials; adults; children
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

NAFLD is a high prevalent disease worldwide, and it is the leading cause of liver-related morbidity and mortality. However, oxidative and inflammatory determinants of this disease have been not fully described. Diet, lifestyle, and co-morbidities are just some of other determinants involved in the genesis and evolution of this disease through modifying oxidative/inflammatory status. There are two types of NAFLD are nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH), and Metabolic dysfunction-associated fatty liver disease (MAFLD) has been lately described, which uses the same standard for NAFLD and NASH, but identifying metabolic dysregulatory factors as requisite for the diagnosis, including metabolic syndrome. Oxidative and inflammatory status are determinants of these diseases. According to diet and lifestyle, this status may be modified, and then risk for these diseases may be increased or not. Further information on these determinants will be useful to improve fatty liver status, its prognosis, and evolution, and hence the public health. This Special Issue will cover all aspects of the role of determinants of NAFLD and its so-morbidities, aiming to provide further knowledge of lifestyle improvement of NAFLD. This Special Issue invites the submission of original research, review articles, and meta-analyses.

Dr. Cristina Bouzas
Prof. Dr. Josep A. Tur
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nonalcoholic fatty liver disease
  • NAFLD
  • metabolic dysfunction-associated fatty liver disease
  • MAFLD
  • nonalcoholic steatohepatitis
  • NASH
  • liver
  • oxidative status
  • inflammation
  • antioxidants

Published Papers (1 paper)

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Research

15 pages, 715 KiB  
Article
Plasma Fatty Acid Composition, Oxidative and Inflammatory Status, and Adherence to the Mediterranean Diet of Patients with Non-Alcoholic Fatty Liver Disease
by Margalida Monserrat-Mesquida, Maria Magdalena Quetglas-Llabrés, Cristina Bouzas, Oscar Pastor, Lucía Ugarriza, Isabel Llompart, Karla Cevallos-Ibarra, Antoni Sureda and Josep A. Tur
Antioxidants 2023, 12(8), 1554; https://doi.org/10.3390/antiox12081554 - 03 Aug 2023
Cited by 3 | Viewed by 1355
Abstract
Non-alcoholic fatty liver disease (NAFLD) is a complex and increasingly prevalent cardiometabolic disorder worldwide. As of today, NAFLD is a pathology without specific pharmacological treatment, with the Mediterranean diet (MedDiet) being the most widely used approach for its management. The objective of this [...] Read more.
Non-alcoholic fatty liver disease (NAFLD) is a complex and increasingly prevalent cardiometabolic disorder worldwide. As of today, NAFLD is a pathology without specific pharmacological treatment, with the Mediterranean diet (MedDiet) being the most widely used approach for its management. The objective of this study is to assess the effects of adherence to the Mediterranean diet on fatty acid plasma levels, as well as on the oxidative and inflammatory status of NAFLD patients. A total of 100 adult patients (40–60 years old) diagnosed with NAFLD and from the Balearic Islands, Spain, were classified into three groups according to their adherence to the MedDiet. Consumption was assessed using a validated 143-item semiquantitative Food Frequency Questionnaire. Food items (g/day) were categorised according to their processing using the NOVA system. Anthropometrics, blood pressure, aminotransferases, Dietary Inflammatory Index (DII), inflammatory biomarkers, and fatty acid levels were measured in the plasma of NAFLD patients. High adherence to the MedDiet is associated to a highly plant-based diet, low ultra-processed food (UPF) consumption, low intake of dietary lipids, low intake of animal fats, high intake of monounsaturated fatty acid (MUFA; mainly palmitoleic acid), low intake of saturated fatty acids (SFAs; practically all dietary SFAs), low intake of trans-fatty acids, high intake of omega-3 fatty acids (mainly eicosapentaenoic acid), a higher n-6:n-3 in ratio, low intake of omega-6 fatty acids, and a low level of interleukin-6 (IL-6). High adherence to the MedDiet is related to a better fatty acid profile in the plasma, fewer SFAs and more MUFA and polyunsaturated fatty acids (PUFAs), a plasma biochemical profile, better proinflammatory status, and decreased ultra-processed food consumption of NAFLD patients. Full article
(This article belongs to the Special Issue Oxidative/Inflammatory Determinants of Non-alcoholic Fatty Liver Disease: The Role of Diet and Lifestyle)
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