Electrospun Nanofibers: Current Advances and Future Perspective

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: 20 July 2024 | Viewed by 4838

Special Issue Editors


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Guest Editor
Green and Innovative Technologies for Food, Environment and Bioengineering Research Group (FEnBeT), Faculty of Pharmacy and Nutrition, UCAM-Universidad Católica San Antonio de Murcia, Campus de los Jerónimos 135, Guadalupe, 30107 Murcia, Spain
Interests: polymer composites; mechanical properties; nanomaterials; biomaterials; membranes; fiber; bioactive molecules; active packaging; water decontamination

E-Mail Website
Guest Editor
Green and Innovative Technologies for Food, Environment and Bioengineering Research Group (FEnBeT), Faculty of Pharmacy and Nutrition, UCAM-Universidad Católica San Antonio de Murcia, Campus de los Jerónimos 135, Guadalupe, 30107 Murcia, Spain
Interests: food science; bioactive molecules; active packaging; water decontamination
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Green and Innovative Technologies for Food, Environment and Bioengineering Research Group (FEnBeT), Faculty of Pharmacy and Nutrition, UCAM-Universidad Católica San Antonio de Murcia, Campus de los Jerónimos 135, Guadalupe, 30107 Murcia, Spain
Interests: food science; bioactive molecules; active packaging; water decontamination

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Guest Editor
Facultad de Ingeniería Agrícola, Universidad Técnica de Manabí (UTM), Avenida Urbina y Che Guevara, Portoviejo 130105, Ecuador
Interests: polymer composites; biomaterials; membranes; fiber; bioactive molecules; water decontamination

Special Issue Information

Dear Colleagues,

The mechanism by which a viscoelastic fluid can be transformed into fibrous membranes under the influence of an electric field was first observed more than a century ago. Since then, many applications of this transformation have been considered, especially after the first electrospinning experiments were reported in the mid-1990s. To date, this technique has allowed the fabrication of fibrous membranes tailored from organic and inorganic precursors, such as polymers and ceramics. Current applications of the electro-spinning technique cover various industrial sectors, with a special emphasis on the areas of food, the environment and bioengineering.

This technique is highly appealing to contemporary researchers owing to its versatility. Indeed, the final performance of these materials is influenced by three main factors. The first main influence is that of the physicochemical properties of the precursor solution such as viscosity, viscoelasticity, conductivity, surface tension, as well as the dielectric constant of the medium. The second major influence came from the experimental variables, related to the configuration used during the electrospinning process, such as the hydrostatic pressure in the capillary tube, the difference in electrical potential at the tip of the capillary, the type of collector, and the distance between the tip and the manifold. Last but not least, the environmental conditions such as temperature, relative humidity, and air speed also play a crucial role. Moreover, these extrinsic factors modulate the structure of the resulting membrane, producing different orientations or morphologies, ranging from microparticles to fibers or mixed morphologies such as fibers functionalized with microparticles. Likewise, this technique not only makes it possible to control the dimensions or diameters of the microparticles, but also allows for the modulation of the morphology and texture of their surface, with structures ranging from those with smooth fibers to rough, porous and hollow structures. Thus, the microstructure of these compounds will modulate their physico-chemical and biological response.

In this Special Issue, we welcome contributions aiming to address the current advances in and future perspectives of electrospun nanofibers. These advances should be applied to various industrial sectors including, but not limited to, the food, environment and bioengineering sectors. Research, covering the combination of natural/synthetic polymers combined with particles, molecules, biomolecules and nanoparticles, as well as aiming to enhance material functionality, is welcome. 

Dr. Camilo Zamora-Ledezma
Dr. Vicente M. Gómez-López
Dr. Patricia Navarro Martínez
Dr. Ezequiel Zamora-Ledezma
Guest Editors

Manuscript Submission Information

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Keywords

  • polymer composites
  • mechanical properties
  • nanomaterials
  • biomaterials
  • membranes
  • fiber
  • bioactive molecules
  • active packaging
  • water decontamination
  • edible films
  • coatings

Published Papers (4 papers)

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Research

14 pages, 8160 KiB  
Communication
Fabrication and Characterization of Electrospun Cu-Doped TiO2 Nanofibers and Enhancement of Photocatalytic Performance Depending on Cu Content and Electron Beam Irradiation
by So-Hyeon Lee, Kyeong-Han Na, Jae-Yoon Kim, Han-Sol Yoon, HyukSu Han and Won-Youl Choi
Polymers 2024, 16(5), 694; https://doi.org/10.3390/polym16050694 - 4 Mar 2024
Viewed by 797
Abstract
Titanium dioxide (TiO₂) is a widely studied material with many attractive properties such as its photocatalytic features. However, its commercial use is limited due to issues such as deactivation in the visible spectrum caused by its wide bandgap and the short lifetime of [...] Read more.
Titanium dioxide (TiO₂) is a widely studied material with many attractive properties such as its photocatalytic features. However, its commercial use is limited due to issues such as deactivation in the visible spectrum caused by its wide bandgap and the short lifetime of photo-excited charge carriers. To overcome these challenges, various modifications could be considered. In this study, we investigated copper doping and electron beam treatment. As-spun TiO2 nanofibers were fabricated by electrospinning a TiO2 sol, which obtained viscosity through a polyvinylpyrrolidone (PVP) matrix. Cu-doped TiO2 nanofibers with varying dopant concentrations were synthesized by adding copper salts. Then, the as-spun nanofibers were calcined for crystallization. To evaluate photocatalytic performance, a photodegradation test of methylene blue aqueous solution was performed for 6 h. Methylene blue concentration was measured over time using UV-Vis spectroscopy. The results showed that Cu doping at an appropriate concentration and electron-beam irradiation showed improved photocatalytic efficiency compared to bare TiO2 nanofibers. When the molar ratio of Cu/Ti was 0.05%, photodegradation rate was highest, which was 10.39% higher than that of bare TiO2. As a result of additional electron-beam treatment of this sample, photocatalytic efficiency improved up to 8.93% compared to samples without electron-beam treatment. Full article
(This article belongs to the Special Issue Electrospun Nanofibers: Current Advances and Future Perspective)
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29 pages, 6632 KiB  
Article
Electrospun Fibers Loaded with Pirfenidone: An Innovative Approach for Scar Modulation in Complex Wounds
by Erika Maria Tottoli, Laura Benedetti, Federica Riva, Enrica Chiesa, Silvia Pisani, Giovanna Bruni, Ida Genta, Bice Conti, Gabriele Ceccarelli and Rossella Dorati
Polymers 2023, 15(20), 4045; https://doi.org/10.3390/polym15204045 - 10 Oct 2023
Cited by 1 | Viewed by 1130
Abstract
Hypertrophic scars (HTSs) are pathological structures resulting from chronic inflammation during the wound healing process, particularly in complex injuries like burns. The aim of this work is to propose Biofiber PF (biodegradable fiber loaded with Pirfenidone 1.5 w/w), an electrospun [...] Read more.
Hypertrophic scars (HTSs) are pathological structures resulting from chronic inflammation during the wound healing process, particularly in complex injuries like burns. The aim of this work is to propose Biofiber PF (biodegradable fiber loaded with Pirfenidone 1.5 w/w), an electrospun advanced dressing, as a solution for HTSs treatment in complex wounds. Biofiber has a 3-day antifibrotic action to modulate the fibrotic process and enhance physiological healing. Its electrospun structure consists of regular well-interconnected Poly-L-lactide-co-poly-ε-caprolactone (PLA-PCL) fibers (size 2.83 ± 0.46 µm) loaded with Pirfenidone (PF, 1.5% w/w), an antifibrotic agent. The textured matrix promotes the exudate balance through mild hydrophobic wettability behavior (109.3 ± 2.3°), and an appropriate equilibrium between the absorbency % (610.2 ± 171.54%) and the moisture vapor transmission rate (0.027 ± 0.036 g/min). Through its finer mechanical properties, Biofiber PF is conformable to the wound area, promoting movement and tissue oxygenation. These features also enhance the excellent elongation (>500%) and tenacity, both in dry and wet conditions. The ancillary antifibrotic action of PF on hypertrophic scar fibroblast (HSF) for 3 days downregulates the cell proliferation over time and modulates the gene expression of transforming growth factor β1 (TGF-β1) and α-smooth muscle actin (α-SMA) at 48–72 h. After 6 days of treatment, a decrement of α-SMA protein levels was detected, proving the potential of biofiber as a valid therapeutic treatment for HTSs in an established wound healing process. Full article
(This article belongs to the Special Issue Electrospun Nanofibers: Current Advances and Future Perspective)
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16 pages, 2576 KiB  
Article
Design and Fabrication of Electrospun PLA-Based Silica-Modified Composite Nanofibers with Antibacterial Properties for Perspective Wound Treatment
by Kateryna Filatova, Eva Domincova Bergerova, Natalia Kazantseva, Milan Masar, Pavol Suly, Tomas Sopik, Jaroslav Cisar, Silvie Durpekova and Vladimir Sedlarik
Polymers 2023, 15(17), 3500; https://doi.org/10.3390/polym15173500 - 22 Aug 2023
Cited by 1 | Viewed by 883
Abstract
The aim of this study was to develop a novel amikacin (AMI) delivery system with prolonged release based on composite electrospun nanofibers of PLA supplemented with AMI-loaded Si nanoparticles of different morphology. The resultant materials were characterized in terms of their physical properties [...] Read more.
The aim of this study was to develop a novel amikacin (AMI) delivery system with prolonged release based on composite electrospun nanofibers of PLA supplemented with AMI-loaded Si nanoparticles of different morphology. The resultant materials were characterized in terms of their physical properties (scanning electron microscopy, Brunauer–Emmett–Teller analysis, thermogravimetric analysis, water contact angle). High-Performance Liquid Chromatography was used to determine the AMI content in the liquid fractions obtained from the release study. The results show that nanofibers of fumed silica exhibited an aggregated, highly porous structure, whereas nanofibers of mesoporous silica had a spherical morphology. Both silica nanoparticles had a significant effect on the hydrophilic properties of PLA nanofiber surfaces. The liquid fractions were investigated to gauge the encapsulation efficiency (EE) and loading efficiency (LE) of AMI, demonstrating 66% EE and 52% LE for nanofibers of fumed silica compared to nanofibers of mesoporous silica nanoparticles (52% EE and 12.7% LE). The antibacterial activity of the AMI-loaded nanofibers was determined by the Kirby–Bauer Method. These results demonstrated that the PLA-based silica nanofibers effectively enhanced the antibacterial properties against the Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae. Full article
(This article belongs to the Special Issue Electrospun Nanofibers: Current Advances and Future Perspective)
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25 pages, 4553 KiB  
Article
Fabrication, Physical–Chemical and Biological Characterization of Retinol-Loaded Poly(vinyl Alcohol) Electrospun Fiber Mats for Wound Healing Applications
by Camilo Zamora-Ledezma, Ana Belén Hernández, Ivan López-González, Jeevithan Elango, Janèle Paindépice, Frank Alexis, Manuela González-Sánchez, Víctor Morales-Flórez, Duncan John Mowbray and Luis Meseguer-Olmo
Polymers 2023, 15(12), 2705; https://doi.org/10.3390/polym15122705 - 16 Jun 2023
Cited by 1 | Viewed by 1369
Abstract
Nowadays, there exists a huge interest in producing innovative, high-performance, biofunctional, and cost-efficient electrospun biomaterials based on the association of biocompatible polymers with bioactive molecules. Such materials are well-known to be promising candidates for three-dimensional biomimetic systems for wound healing applications because they [...] Read more.
Nowadays, there exists a huge interest in producing innovative, high-performance, biofunctional, and cost-efficient electrospun biomaterials based on the association of biocompatible polymers with bioactive molecules. Such materials are well-known to be promising candidates for three-dimensional biomimetic systems for wound healing applications because they can mimic the native skin microenvironment; however, many open questions such as the interaction mechanism between the skin and the wound dressing material remain unclear. Recently, several biomolecules were intended for use in combination with poly(vinyl alcohol) (PVA) fiber mats to improve their biological response; nevertheless, retinol, an important biomolecule, has not been combined yet with PVA to produce tailored and biofunctional fiber mats. Based on the abovementioned concept, the present work reported the fabrication of retinol-loaded PVA electrospun fiber mats (RPFM) with a variable content of retinol (0 ≤ Ret ≤ 25 wt.%), and their physical–chemical and biological characterization. SEM results showed that fiber mats exhibited diameters distribution ranging from 150 to 225 nm and their mechanical properties were affected with the increasing of retinol concentrations. In addition, fiber mats were able to release up to 87% of the retinol depending on both the time and the initial content of retinol. The cell culture results using primary mesenchymal stem cell cultures proved the biocompatibility of RPFM as confirmed by their effects on cytotoxicity (low level) and proliferation (high rate) in a dose-dependent manner. Moreover, the wound healing assay suggested that the optimal RPFM with retinol content of 6.25 wt.% (RPFM-1) enhanced the cell migratory activity without altering its morphology. Accordingly, it is demonstrated that the fabricated RPFM with retinol content below the threshold 0 ≤ Ret ≤ 6.25 wt.% would be an appropriate system for skin regenerative application. Full article
(This article belongs to the Special Issue Electrospun Nanofibers: Current Advances and Future Perspective)
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