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Special Issue "Structure-Function Relationships in Viral Polymerases"

A special issue of Viruses (ISSN 1999-4915).

Deadline for manuscript submissions: closed (15 October 2017)

Special Issue Editor

Guest Editor
Dr. Olve Peersen

Department of Biochemistry & Molecular Biology, Colorado State University, Fort Collins, CO 80523-1870, USA
Website | E-Mail
Interests: RNA virus replication complexes; polymerase fidelity; structural biology; enzyme kinetics

Special Issue Information

Dear Colleague,

Over the past decade our structural biology knowledge of viral polymerases and the detailed molecular interactions involved in viral genome replication has increased dramatically. We are well poised for a global comparison of these structures that highlights both commonalities among and within virus families and the unique and important aspects of individual structures. Thus, this Special Issue of Viruses is focused on viral polymerase structures and our understanding of their molecular mechanisms. The manuscripts will embrace structural biology, but they need not be strictly structure based; for example, a biochemically oriented research or review paper that leans more toward the function side of structure-function studies would be welcome.

This issue will be accompanied by an extensive collection of on-line materials in the form of movies that illustrate key elements of individual polymerase structures and comparisons of multiple structures. This is perhaps the most effective way to instil an appreciation for structure, especially for a more general virologist audience. As editor, I will work closely with the authors to develop a consistent set of molecular representations that facilitate comparisons of different polymerases. Examples of common themes to be highlighted are downstream and upstream nucleic acid interactions, strand separation mechanisms, initiation mechanisms, active site interactions and dynamics during catalysis, nucleotide selectivity, and translocation events. Suggestions for additional themes are welcome.
Guidelines for manuscript submission are shown below and authors specifically interested in partaking in the multimedia aspects of this Special Issue should contact the guest editor directly (Olve.Peersen@ColoState.edu) for initial guidance about manuscript sections and organization.

Dr. Olve Peersen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

• polymerase structure
• replication

Published Papers (1 paper)

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Review

Open AccessReview The Battle of RNA Synthesis: Virus versus Host
Viruses 2017, 9(10), 309; doi:10.3390/v9100309
Received: 15 September 2017 / Revised: 19 October 2017 / Accepted: 20 October 2017 / Published: 21 October 2017
PDF Full-text (969 KB) | HTML Full-text | XML Full-text
Abstract
Transcription control is the foundation of gene regulation. Whereas a cell is fully equipped for this task, viruses often depend on the host to supply tools for their transcription program. Over the course of evolution and adaptation, viruses have found diverse ways to
[...] Read more.
Transcription control is the foundation of gene regulation. Whereas a cell is fully equipped for this task, viruses often depend on the host to supply tools for their transcription program. Over the course of evolution and adaptation, viruses have found diverse ways to optimally exploit cellular host processes such as transcription to their own benefit. Just as cells are increasingly understood to employ nascent RNAs in transcription regulation, recent discoveries are revealing how viruses use nascent RNAs to benefit their own gene expression. In this review, we first outline the two different transcription programs used by viruses, i.e., transcription (DNA-dependent) and RNA-dependent RNA synthesis. Subsequently, we use the distinct stages (initiation, elongation, termination) to describe the latest insights into nascent RNA-mediated regulation in the context of each relevant stage. Full article
(This article belongs to the Special Issue Structure-Function Relationships in Viral Polymerases)
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