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Open AccessArticle
The Type III Effector XopLXcc in Xanthomonas campestris pv. campestris Targets the Proton Pump Interactor 1 and Suppresses Innate Immunity in Arabidopsis
by
Jing Huang
Jing Huang 1,
Yuru Dong
Yuru Dong 1,
Nana Li
Nana Li 1,
Yongqiang He
Yongqiang He 1,* and
Hao Zhou
Hao Zhou 1,2,*
1
State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning 530005, China
2
Guangxi Key Laboratory for Polysaccharide Materials and Modifications, Guangxi Minzu University, Nanning 530006, China
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(17), 9175; https://doi.org/10.3390/ijms25179175 (registering DOI)
Submission received: 24 July 2024
/
Revised: 16 August 2024
/
Accepted: 20 August 2024
/
Published: 23 August 2024
Abstract
Xanthomonas campestris pathovar campestris (Xcc) is a significant phytopathogen causing black rot disease in crucifers. Xcc injects a variety of type III effectors (T3Es) into the host cell to assist infection or propagation. A number of T3Es inhibit plant immunity, but the biochemical basis for a vast majority of them remains unknown. Previous research has revealed that the evolutionarily conserved XopL-family effector XopLXcc inhibits plant immunity, although the underlying mechanisms remain incompletely elucidated. In this study, we identified proton pump interactor (PPI1) as a specific virulence target of XopLXcc in Arabidopsis. Notably, the C-terminus of PPI1 and the Leucine-rich repeat (LRR) domains of XopLXcc are pivotal for facilitating this interaction. Our findings indicate that PPI1 plays a role in the immune response of Arabidopsis to Xcc. These results propose a model in which XopLXcc binds to PPI1, disrupting the early defense responses activated in Arabidopsis during Xcc infection and providing valuable insights into potential strategies for regulating plasma membrane (PM) H+-ATPase activity during infection. These novel insights enhance our understanding of the pathogenic mechanisms of T3Es and contribute to the development of effective strategies for controlling bacterial diseases.
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MDPI and ACS Style
Huang, J.; Dong, Y.; Li, N.; He, Y.; Zhou, H.
The Type III Effector XopLXcc in Xanthomonas campestris pv. campestris Targets the Proton Pump Interactor 1 and Suppresses Innate Immunity in Arabidopsis. Int. J. Mol. Sci. 2024, 25, 9175.
https://doi.org/10.3390/ijms25179175
AMA Style
Huang J, Dong Y, Li N, He Y, Zhou H.
The Type III Effector XopLXcc in Xanthomonas campestris pv. campestris Targets the Proton Pump Interactor 1 and Suppresses Innate Immunity in Arabidopsis. International Journal of Molecular Sciences. 2024; 25(17):9175.
https://doi.org/10.3390/ijms25179175
Chicago/Turabian Style
Huang, Jing, Yuru Dong, Nana Li, Yongqiang He, and Hao Zhou.
2024. "The Type III Effector XopLXcc in Xanthomonas campestris pv. campestris Targets the Proton Pump Interactor 1 and Suppresses Innate Immunity in Arabidopsis" International Journal of Molecular Sciences 25, no. 17: 9175.
https://doi.org/10.3390/ijms25179175
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