Modulation of Multidrug Resistance Transporters by Food Components and Dietary Supplements: Implications for Cancer Therapy Efficacy and Safety
Abstract
:1. Introduction
2. Methods
3. Function of Selected Carriers Involved in Transport of Anticancer Drugs
3.1. Multidrug Resistance-Associated Protein 2—MRP2
3.2. Breast Cancer Resistance Protein—BCRP
3.3. P-Glycoprotein—P-gp
4. Influence of Polyphenolic Compounds on MDR Transporters
4.1. Catechins
4.2. Quercetin and Its Derivatives
4.3. Apigenin
4.4. Licochalcone A
4.5. Miscellaneous Flavonoids
4.6. Sinapic Acid
4.7. Resveratrol
4.8. Curcumin
5. Effect of Terpenoids and Sterols on MDR Transporters
5.1. Menthol
5.2. Geraniol
5.3. β-Caryophyllene Oxide
5.4. Carnosic Acid and Carnosol
5.5. Beta-Sitosterol
6. Effect of Alkaloids on MDR Transporters
6.1. Berberine
6.2. Capsaicin
6.3. Piperine
7. Effect of Plant Juices on MDR Transporters
7.1. Rocket Juice
7.2. Cranberry Juice
8. Structure–Activity Relationship
9. The Study Limitations
10. Conclusions
- Enhanced efficacy through targeted nutrients: Incorporating a diet rich in specific nutrients, e.g., antioxidants, has been shown to improve specific aspects of chemotherapy efficacy, e.g., tumor response in in vitro or animal studies. However, patients undergoing chemotherapy should be careful in increasing the intake of these nutrients, especially when taken as dietary supplements, and consult healthcare professionals.
- Potential dietary modifications: Based on our findings, we recommend that patients should discuss the possibility of dietary modifications with their oncologists with the help of a clinical pharmacist and clinical dietician. These changes could potentially optimize the effectiveness of chemotherapy and improve overall patient well-being.
- Personalized dietary plans: It is essential for dietary recommendations to be tailored to the individual patient, considering factors such as specific type of cancer, treatment regimen, and personal health conditions. Personalized dietary plans should be developed in collaboration with nutritionists and healthcare providers to ensure the best possible outcomes.
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Brodzicka, A.; Galanty, A.; Paśko, P. Modulation of Multidrug Resistance Transporters by Food Components and Dietary Supplements: Implications for Cancer Therapy Efficacy and Safety. Curr. Issues Mol. Biol. 2024, 46, 9686-9706. https://doi.org/10.3390/cimb46090576
Brodzicka A, Galanty A, Paśko P. Modulation of Multidrug Resistance Transporters by Food Components and Dietary Supplements: Implications for Cancer Therapy Efficacy and Safety. Current Issues in Molecular Biology. 2024; 46(9):9686-9706. https://doi.org/10.3390/cimb46090576
Chicago/Turabian StyleBrodzicka, Agnieszka, Agnieszka Galanty, and Paweł Paśko. 2024. "Modulation of Multidrug Resistance Transporters by Food Components and Dietary Supplements: Implications for Cancer Therapy Efficacy and Safety" Current Issues in Molecular Biology 46, no. 9: 9686-9706. https://doi.org/10.3390/cimb46090576