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Open AccessReview
An Up-to-Date Review of Materials Science Advances in Bone Grafting for Oral and Maxillofacial Pathology
by
Carmen-Larisa Nicolae
Carmen-Larisa Nicolae 1,
Diana-Cristina Pîrvulescu
Diana-Cristina Pîrvulescu 2,
Adelina-Gabriela Niculescu
Adelina-Gabriela Niculescu 2,3,
Dragoș Epistatu
Dragoș Epistatu 1,
Dan Eduard Mihaiescu
Dan Eduard Mihaiescu 2,
Alexandru Mihai Antohi
Alexandru Mihai Antohi 1,
Alexandru Mihai Grumezescu
Alexandru Mihai Grumezescu 2,3,* and
George-Alexandru Croitoru
George-Alexandru Croitoru 1
1
Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania
2
Faculty of Chemical Engineering and Biotechnology, National University of Science and Technology Politehnica Bucharest, 011061 Bucharest, Romania
3
Research Institute of the University of Bucharest—ICUB, University of Bucharest, 050657 Bucharest, Romania
*
Author to whom correspondence should be addressed.
Materials 2024, 17(19), 4782; https://doi.org/10.3390/ma17194782 (registering DOI)
Submission received: 14 August 2024
/
Revised: 15 September 2024
/
Accepted: 27 September 2024
/
Published: 28 September 2024
Abstract
Bone grafting in oral and maxillofacial surgery has evolved significantly due to developments in materials science, offering innovative alternatives for the repair of bone defects. A few grafts are currently used in clinical settings, including autografts, xenografts, and allografts. However, despite their benefits, they have some challenges, such as limited availability, the possibility of disease transmission, and lack of personalization for the defect. Synthetic bone grafts have gained attention since they have the potential to overcome these limitations. Moreover, new technologies like nanotechnology, 3D printing, and 3D bioprinting have allowed the incorporation of molecules or substances within grafts to aid in bone repair. The addition of different moieties, such as growth factors, stem cells, and nanomaterials, has been reported to help mimic the natural bone healing process more closely, promoting faster and more complete regeneration. In this regard, this review explores the currently available bone grafts, the possibility of incorporating substances and molecules into their composition to accelerate and improve bone regeneration, and advanced graft manufacturing techniques. Furthermore, the presented current clinical applications and success stories for novel bone grafts emphasize the future potential of synthetic grafts and biomaterial innovations in improving patient outcomes in oral and maxillofacial surgery.
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MDPI and ACS Style
Nicolae, C.-L.; Pîrvulescu, D.-C.; Niculescu, A.-G.; Epistatu, D.; Mihaiescu, D.E.; Antohi, A.M.; Grumezescu, A.M.; Croitoru, G.-A.
An Up-to-Date Review of Materials Science Advances in Bone Grafting for Oral and Maxillofacial Pathology. Materials 2024, 17, 4782.
https://doi.org/10.3390/ma17194782
AMA Style
Nicolae C-L, Pîrvulescu D-C, Niculescu A-G, Epistatu D, Mihaiescu DE, Antohi AM, Grumezescu AM, Croitoru G-A.
An Up-to-Date Review of Materials Science Advances in Bone Grafting for Oral and Maxillofacial Pathology. Materials. 2024; 17(19):4782.
https://doi.org/10.3390/ma17194782
Chicago/Turabian Style
Nicolae, Carmen-Larisa, Diana-Cristina Pîrvulescu, Adelina-Gabriela Niculescu, Dragoș Epistatu, Dan Eduard Mihaiescu, Alexandru Mihai Antohi, Alexandru Mihai Grumezescu, and George-Alexandru Croitoru.
2024. "An Up-to-Date Review of Materials Science Advances in Bone Grafting for Oral and Maxillofacial Pathology" Materials 17, no. 19: 4782.
https://doi.org/10.3390/ma17194782
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