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Journal of Xenobiotics, Volume 15, Issue 3

2025 June - 34 articles

Cover Story: The increasing occurrence of emerging contaminants in aquatic ecosystems has raised concerns about their potential ecological impacts. Caffeine (CAF) is a widely consumed alkaloid and frequently detected compound in surface waters and urban effluents. Although often considered a low-priority contaminant in regulatory frameworks, recent studies have shown that CAF exposure can induce sub-lethal effects in aquatic organisms, compromising their physiological integrity and ecological functions. Several studies evaluating the ecotoxicity of CAF highlight the importance of including organisms from multiple trophic levels and examining individual and sub-individual responses. This approach supports more robust environmental risk assessments, particularly under environmentally relevant scenarios. View this paper
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Articles (34)

  • Article
  • Open Access
1,927 Views
35 Pages

Environmental exposures to heavy metals, polychlorinated biphenyls (PCBs), dioxins, and furans have been associated with adverse cardiovascular outcomes, yet their combined effects remain underexplored. This study examined the joint influence of thes...

  • Article
  • Open Access
1 Citations
1,244 Views
18 Pages

The development of alternative methods that link cellular and predictive toxicity to high-level toxicity is a key focus of current research within the framework of the 3Rs in animal experimentation. In this context, this study aimed to evaluate the p...

  • Article
  • Open Access
2 Citations
3,258 Views
30 Pages

Comprehensive Risk Assessment of Metals and Minerals in Seafood Using Bioaccessibility Correction

  • Ștefania-Adelina Milea,
  • Ira-Adeline Simionov,
  • Nina-Nicoleta Lazăr,
  • Cătălina Iticescu,
  • Mihaela Timofti,
  • Puiu-Lucian Georgescu and
  • Caterina Faggio

Evaluating the bioaccessibility and health risks of seafood is extremely important because, although it is a significant source of vital minerals, it may also contain potentially toxic elements. This study aimed to determine the content of metals and...

  • Article
  • Open Access
5 Citations
2,472 Views
16 Pages

GABA and Octopamine Receptors as Potential Targets for Fumigant Actions of Bursera graveolens Essential Oil Against Callosobruchus maculatus and Callosobruchus chinensis

  • Luis O. Viteri,
  • Maria José González,
  • Pedro B. Silva,
  • Jonatas M. Gomes,
  • Thiago Svacina,
  • Lara T. M. Costa,
  • Eduardo Valarezo,
  • Javier G. Mantilla-Afanador,
  • Osmany M. Herrera and
  • Eugênio E. Oliveira
  • + 2 authors

Cowpea, Vigna sp., is an important, low-cost protein source in subtropical and semi-arid regions, where seasonal rainfall makes storage necessary. However, the weevils Callosobruchus maculatus and C. chinensis cause significant grain losses during st...

  • Communication
  • Open Access
1 Citations
1,126 Views
11 Pages

The Insecticide Imidacloprid Promotes Algal Growth in Absence of Zooplankton

  • Verónica Laura Lozano,
  • Florencia Soledad Alvarez Dalinger and
  • Liliana Beatriz Moraña

Imidacloprid, a systemic neonicotinoid insecticide, exerts its neurotoxic effects by binding to nicotinic acetylcholine receptors in the central nervous system. In this study, we examined the effects of commercial imidacloprid formulations on the gro...

  • Editorial
  • Open Access
1,217 Views
4 Pages

Legacy and Emerging Pollutants and Their Effects Through the Lens of Environmental Management

  • Christina Emmanouil,
  • Petros Samaras and
  • Dorothea Kassiteropoulou

In the quest for worldwide economic development, the principles of sustainable development that involve social justice and efficient environmental protection are sometimes forgotten [...]

  • Article
  • Open Access
5 Citations
14,372 Views
18 Pages

The Occurrence of Illicit Smart Drugs or Nootropics in Europe and Australia and Their Associated Dangers: Results from a Market Surveillance Study by 12 Official Medicines Control Laboratories

  • Celine Vanhee,
  • Eric Deconinck,
  • Mark George,
  • Andrew Hansen,
  • Andreas Hackl,
  • Uwe Wollein,
  • Oliver El-Atma,
  • Nico Beerbaum,
  • Federica Aureli and
  • Marta Miquel
  • + 9 authors

In recent years, an increasing number of case reports have mentioned the presence of illicit nootropics, smart drugs or mind doping products on the market. To better understand the extent of the problem, a market surveillance study was organised by t...

  • Article
  • Open Access
1,136 Views
16 Pages

Avena sativa as a Multifunctional Tool for Phytoremediation and Bioenergy Production in Sulfentrazone Contaminated Soils

  • Caique Menezes de Abreu,
  • Guilherme Henrique Fernandes Carneiro,
  • Márcia Regina da Costa,
  • Gabriela Madureira Barroso,
  • Tayna Sousa Duque,
  • Joice Mariana Santos Silva and
  • José Barbosa dos Santos

Phytoremediation using Avena sativa offers a sustainable strategy for mitigating sulfentrazone contamination while integrating bioenergy production. This study proposes an analysis of the bioenergy potential and the microbial metagenomic profile asso...

  • Article
  • Open Access
4 Citations
4,029 Views
21 Pages

This study evaluates the effects of caffeine (CAF) on the bacteria Aliivibrio fischeri, the microalga Raphidocelis subcapitata, the macrophyte Lemna minor, and the larvae of Chironomus riparius, aiming to understand its environmental impact and contr...

  • Review
  • Open Access
3 Citations
5,869 Views
23 Pages

Microplastic (MP) contamination affects all environmental media, even in remote, unpopulated regions of the globe. Many studies have addressed this issue under various aspects; however, actual and definitive evidence that MPs are a cause of human hea...

  • Article
  • Open Access
1 Citations
1,483 Views
15 Pages

Background: The toxicity of pesticides for fish in general and Rainbow Trout (Oncorhynchus mykiss) in particular is an important ecological indicator required by regulations, and it implies the use of a large number of fish. The number of animals nee...

  • Review
  • Open Access
11 Citations
6,974 Views
31 Pages

Neurotoxic Effects of Pesticides: Implications for Neurodegenerative and Neurobehavioral Disorders

  • Alexandra Andreea Botnaru,
  • Ancuta Lupu,
  • Paula Cristina Morariu,
  • Alexandra Jităreanu,
  • Alin Horatiu Nedelcu,
  • Branco Adrian Morariu,
  • Emil Anton,
  • Maria Luisa Di Gioia,
  • Vasile Valeriu Lupu and
  • Ionela Daniela Morariu
  • + 2 authors

Pesticides play an essential role in modern agriculture, yet increasing evidence links their widespread use to neurotoxic effects that contribute to both neurodegenerative and neurodevelopmental disorders. In recent years, new classes of pesticides s...

  • Article
  • Open Access
1 Citations
1,630 Views
14 Pages

Polycyclic aromatic hydrocarbons (PAHs), prevalent aquatic contaminants, arise from burning fossil fuels, a major source of greenhouse gases driving global warming. PAHs and warmer temperatures individually exert diverse negative effects on aquatic o...

  • Article
  • Open Access
3 Citations
2,884 Views
25 Pages

The occurrence of per- and polyfluoroalkyl substances (PFASs) in drinking water remains a critical environmental and public health concern. This study examines the presence of both regulated and unregulated PFASs in twenty-one bottled water and twent...

  • Article
  • Open Access
2 Citations
3,308 Views
13 Pages

QSAR Models for Predicting the Antioxidant Potential of Chemical Substances

  • Sofia Ghironi,
  • Edoardo Luca Viganò,
  • Gianluca Selvestrel and
  • Emilio Benfenati

Antioxidants are widely studied compounds with significant applications in the nutraceutical and dietary industries. To enable the rapid screening of large libraries of substances for antioxidant activity and to provide a useful tool for the initial...

  • Article
  • Open Access
1,467 Views
21 Pages

Ecotoxicity of Fire Retardants to Zebrafish (Danio rerio) in Early Life Stages

  • Darlan Quinta Brito,
  • Tathyana Benetis Piau,
  • Carlos Henke-Oliveira,
  • Eduardo Cyrino Oliveira-Filho and
  • Cesar Koppe Grisolia

With the escalating frequency and intensity of global wildfires driven by climate change, fire retardants (FRs) have become essential tools in wildfire management. Despite their widespread use, the environmental safety of newer FR formulations—...

  • Article
  • Open Access
9 Citations
4,336 Views
26 Pages

Occurrence of 97 Pharmaceuticals in Wastewater and Receiving Waters: Analytical Validation and Treatment Influence

  • Paula Paíga,
  • Sónia Figueiredo,
  • Manuela Correia,
  • Magda André,
  • Roberto Barbosa,
  • Sandra Jorge and
  • Cristina Delerue-Matos

This study analyzed 97 pharmaceuticals in samples of surface water, as well as influent and effluent from various wastewater treatment plants (WWTPs), during winter 2022 and spring 2023. Approximately 40% of the tested compounds were detected, at amo...

  • Article
  • Open Access
1,188 Views
18 Pages

Effects of a Proteinase Inhibitor from Inga laurina Seeds (ILTI) on Aedes aegypti Larval Development

  • Ana Jacobowski,
  • Welington Leite,
  • Antolim Martinez Júnior,
  • Eduarda Reis,
  • Lorena Pires,
  • Vitória Silva,
  • Layza Rocha,
  • Eduardo Arruda,
  • Octávio Franco and
  • Maria Macedo
  • + 2 authors

Aedes aegypti (Linnaeus, 1762) is Brazil’s primary vector of epidemiologically significant arboviruses such as yellow fever, dengue, Zika, and chikungunya. Despite using conventional chemical control measures, this species has developed resista...

  • Review
  • Open Access
7 Citations
4,261 Views
49 Pages

Incessant urbanization and industrialization have resulted in several pollutants being increasingly produced and continuously discharged into the environment, altering its equilibrium, with a high risk for living organisms’ health. To restore i...

  • Systematic Review
  • Open Access
8 Citations
6,966 Views
25 Pages

Nanoplastic (NP) pollution has emerged as a growing concern due to its potential impact on human health, although its adverse effects on different organ systems are not yet fully understood. This systematic scoping review, conducted in accordance wit...

  • Article
  • Open Access
2 Citations
1,402 Views
17 Pages

Assessment of Selected Heavy Metals and Arsenic Concentrations in Wild Boar (Sus scrofa L.) from Papuk Nature Park (Croatia)

  • Domagoj Vidosavljević,
  • Miroslav Venus,
  • Dinko Puntarić,
  • Lidija Kalinić,
  • Marina Vidosavljević,
  • Mario Begović,
  • Marta Despot and
  • Vlatka Gvozdić

The aim of this study was to measure the concentrations of As, Cd, Hg, Pb, Cr, Cu, Fe and Zn in the muscle, liver and kidney of wild boar (Sus scrofa) in Papuk Nature Park, Eastern Croatia. Muscles, liver and kidney of 38 wild boars, up to 3 years of...

  • Review
  • Open Access
4 Citations
2,065 Views
19 Pages

The Exposome and the Kidney: A Silent Dialogue Shaping Chronic Kidney Disease

  • Livia Alvarenga,
  • Marcia Ribeiro,
  • Ludmila F. M. F. Cardozo,
  • Natália A. Borges,
  • Peter Stenvinkel and
  • Denise Mafra

Genetic predisposition accounts for less than 20% of the global disease burden, highlighting the substantial role of environmental factors in health outcomes. In chronic kidney disease (CKD), a growing global prevalence, understanding the interplay b...

  • Review
  • Open Access
3 Citations
1,829 Views
29 Pages

Phthalates, a group of synthetic non-persistent organic chemicals commonly used as solvents and plasticisers, have been associated with a range of detrimental health effects. These endocrine disrupting chemicals (ECDs) may exert their effects through...

  • Review
  • Open Access
1 Citations
2,382 Views
13 Pages

Air Pollution and Pituitary Adenoma Pathogenesis: Unraveling Environmental Impacts on Neuroendocrine Function and Tumorigenesis

  • Andre E. Boyke,
  • Simon A. Menaker,
  • Alberto Nunez,
  • Keith L. Black and
  • Vladimir A. Ljubimov

Pituitary adenomas, although predominantly benign, can lead to significant clinical complications due to endocrine imbalances and mass effects on adjacent structures. Traditional research has focused on intrinsic factors like genetic mutations and ho...

  • Article
  • Open Access
1 Citations
838 Views
14 Pages

Role of Native Arbuscular Mycorrhizal Fungi in Modulating Nutrient Subcellular Distribution in Wheat Grown in Mn-Toxic Soil

  • Jorge Miguel Silva Faria,
  • Ana Paula Pinto,
  • Pedro Barrulas,
  • Isabel Brito and
  • Dora M. Teixeira

Heavy metal toxicity leads to impaired crop growth and reduced crop yields and product quality by disrupting plant nutrient uptake, inhibiting development, inducing oxidative stress, and causing cellular toxicity. Arbuscular mycorrhizal fungi (AMF) c...

  • Article
  • Open Access
1,140 Views
15 Pages

Effect of Retinoic Acid on the Cerebral Vasculature: Analysis of the Vasoactive Response of Smooth Muscle Cells in Normal and Ischemic Contexts

  • Manuel R. Pouso,
  • Emanuel Farinha,
  • Henrique E. Costa,
  • Margarida Lorigo,
  • Graça Baltazar and
  • Elisa Cairrao

Retinoic acid (RA), a vitamin A derivative, has been shown to prevent the development of neurological disorders by ensuring the integrity of the physiological structure of the neurovascular unit and regulating the physiological cell’s function....

  • Article
  • Open Access
2 Citations
1,945 Views
24 Pages

Cardiovascular diseases (CVDs) are the leading cause of mortality globally, accounting for approximately one-third of all deaths. Exposure to toxic metals poses significant risks to cardiovascular health, contributing to the development of CVDs. Esse...

  • Article
  • Open Access
2 Citations
2,240 Views
14 Pages

Ames Assay Transferred from the Microtiter Plate to the Planar Assay Format

  • Katharina Schmidtmann,
  • Johanna Lemme and
  • Gertrud E. Morlock

The International Agency for Research on Cancer has studied and classified 1045 potential substances. It is therefore important to develop rapid screening methods to identify the mutagenicity of compounds and, further on, the intensity and number of...

  • Article
  • Open Access
1 Citations
1,553 Views
13 Pages

COMT Genetic Variants and BDNF Level Associations with Cannabinoid Plasma Exposure: A Preliminary Study

  • Alessandra Manca,
  • Cristina Valz,
  • Francesco Chiara,
  • Alice Palermiti,
  • Jacopo Mula,
  • Sara Soloperto,
  • Miriam Antonucci,
  • Amedeo De Nicolò,
  • Nicola Luxardo and
  • Antonio D’Avolio
  • + 4 authors

Cannabis sativa L. shows potent anti-inflammatory activity, resulting in an interesting pharmacological option for pain management. The aim of the study was to evaluate the association between pharmacogenetics, neurological and inflammatory biomarker...

  • Article
  • Open Access
797 Views
13 Pages

Glyphosate based-herbicides are stressors of great concern because they can impact aquatic ecosystems. Similarly, lithium, a metal, is currently of concern because of its increasing use worldwide. Because glyphosate-based herbicides and lithium might...

  • Article
  • Open Access
4 Citations
5,467 Views
19 Pages

29 April 2025

The excessive intake of monosodium glutamate (MSG) increases its cellular levels in different organs and induces organ toxicity. The current study aims to investigate the metabolic changes and possible causes of hepatic, renal, and cardiac toxicity i...

  • Review
  • Open Access
18 Citations
4,552 Views
41 Pages

Innovative Approaches and Evolving Strategies in Heavy Metal Bioremediation: Current Limitations and Future Opportunities

  • Cristina Firincă,
  • Lucian-Gabriel Zamfir,
  • Mariana Constantin,
  • Iuliana Răut,
  • Maria-Luiza Jecu,
  • Mihaela Doni,
  • Ana-Maria Gurban and
  • Tatiana Eugenia Șesan

26 April 2025

Decades of technological advancements have led to major environmental concerns, particularly the bioaccumulation of heavy metals, which pose persistent risks to ecosystems and human health. Consequently, research has increasingly shifted from convent...

  • Article
  • Open Access
1,524 Views
19 Pages

Naphthenic Acid Fraction Components-Induced Metabolic and Mitochondrial Alterations in Rat Hepatoma Cells: Monitoring Metabolic Reprogramming with Tryptophan–Kynurenine Ratio

  • Laiba Jamshed,
  • Amica Marie-Lucas,
  • Genevieve A. Perono,
  • Gregg T. Tomy,
  • Jim J. Petrik,
  • Richard A. Frank,
  • L. Mark Hewitt,
  • Philippe J. Thomas and
  • Alison C. Holloway

24 April 2025

Altered body condition and diminished growth in wildlife in the Alberta Oil Sands Region (AOSR) are prompting investigations into the impact of oil sands industrial activity on wildlife in the region. Chemical constituents from bitumen-influenced wat...

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J. Xenobiot. - ISSN 2039-4713