Next Article in Journal
QSAR-Based Drug Repurposing and RNA-Seq Metabolic Networks Highlight Treatment Opportunities for Hepatocellular Carcinoma Through Pyrimidine Starvation
Previous Article in Journal
A Peptide Derived from Nectin-4 Increases Cisplatin Cytotoxicity in Cell Lines and Cells from Ovarian Cancer Patients’ Ascites
Previous Article in Special Issue
Real-Life Comparative Analysis of Robotic-Assisted Versus Laparoscopic Radical Prostatectomy in a Single Centre Experience
 
 
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Recent Advances in Radical Prostatectomy: A Narrative Review of Surgical Innovations and Outcomes

1
Department of Pharmacology, Korea University College of Medicine, Korea University, 73 Goryeodae-ro, Seongbuk-gu, Seoul 02841, Republic of Korea
2
Department of Urology, Korea University Guro Hospital, Korea University College of Medicine, Seoul 08308, Republic of Korea
*
Author to whom correspondence should be addressed.
Cancers 2025, 17(5), 902; https://doi.org/10.3390/cancers17050902
Submission received: 26 January 2025 / Revised: 26 February 2025 / Accepted: 4 March 2025 / Published: 6 March 2025
(This article belongs to the Special Issue Novel Advances in Surgery for Prostate Cancer)

Simple Summary

Prostate cancer is a leading health concern among men worldwide. Traditional surgical treatments often result in significant side effects that affect the quality of life. Our research examines recent advancements in surgical techniques, such as robot-assisted procedures, aimed at effectively treating prostate cancer while minimizing adverse effects. By evaluating these innovations, we aimed to provide insights that can guide future research and improve patient outcomes.

Abstract

Prostate cancer is one of the most commonly diagnosed malignancies worldwide and is a major cause of cancer-associated morbidity in men. Radical prostatectomy (RP) is a cornerstone of intervention for organ-confined diseases and offers a potentially curative outcome. In recent decades, RP has undergone transformative changes, moving from open surgery, with significant morbidity, to minimally invasive and robot-assisted techniques. These advances have improved surgical precision, reduced blood loss, and accelerated functional recovery. Key enhancements, such as the “Veil of Aphrodite”, hood-sparing, and Retzius-sparing approaches, aim to preserve neurovascular structures vital for continence and sexual function, addressing the persistent challenge of balancing oncological control with quality-of-life outcomes. Single-port (SP) robotic platforms represent the latest frontier, offering various access routes, including extraperitoneal, transvesical, transperitoneal, and transperineal routes, to further reduce incisional morbidity. Early experiences with SP robot-assisted radical prostatectomy(RARP) suggest favorable continence rates and short hospital stays, although concerns remain regarding the technical complexity and potential margin status of the advanced disease. Comparisons across these techniques revealed broadly similar long-term oncological outcomes, underscoring the importance of patient selection, tumor staging, and surgeon expertise. Ongoing innovations in robotic systems, augmented imaging modalities, and personalized surgical planning are likely to refine prostate cancer care and enhance both survival and post-treatment quality of life.

1. Introduction

Prostate cancer is one of the most frequently diagnosed malignancies in men worldwide, with an increasing incidence as the population ages [1,2,3]. Radical prostatectomy (RP) has long been the cornerstone therapy for patients with organ-confined diseases, providing curative potential. Over the past few decades, RP has evolved from open approaches with significant morbidity to minimally invasive options that reduce complications and aim to preserve quality of life. Laparoscopic radical prostatectomy introduced smaller incisions and faster convalescence but was technically challenging due to limited instrument articulation and two-dimensional vision [4,5]. The advent of robot-assisted radical prostatectomy (RARP) at the turn of the century has transformed prostate surgery by enabling enhanced 3D visualization, wristed instrumentation, and stable camera control [6,7]. Currently, RARP has become the dominant modality in many centers across high-income nations and has led to reduced blood loss, shorter hospital stays, and early functional recovery than open surgery [8,9]. Despite these advancements, the pursuit of improving key outcomes such as urinary continence and sexual function continues. Surgeons have developed novel dissection planes and techniques (e.g., Retzius-sparing and hood-sparing) to preserve the periurethral or anterior supporting structures that are believed to be critical for early continence recovery [10,11,12,13]. Most recently, single-port (SP) robotic platforms have been adopted, expanding the potential approaches (extraperitoneal, transperitoneal, perineal, and transvesical) to reduce incisional morbidity [14,15,16]. The continued evolution of surgical techniques and technologies in radical prostatectomy reflects the ongoing efforts to balance oncological control with the preservation of quality of life. This review examines the latest advances in radical prostatectomy, emphasizing innovations in techniques and outcomes that have shaped current clinical practice. By understanding the progression from open to robot-assisted and single-port approaches, as well as comparing emerging techniques such as hood-sparing and Retzius-sparing, this narrative review aims to provide a comprehensive overview for clinicians seeking to optimize prostate cancer management.

2. The History and Evolution of Radical Prostatectomy

The treatment of prostate cancer dates back to 1904 when Hugh Hampton Young in the United States performed the first radical prostatectomy using the perineal approach. Despite its significant limitations, including high blood loss, this procedure is recognized as the foundation for modern prostate cancer surgery [17]. In 1945, British surgeon Terence Millin introduced the retropubic approach, which improved surgical visualization and reduced bleeding, enhancing the safety of the operation [18]. However, it still carries significant side effects, such as impotence and urinary incontinence. In 1982, Dr. Patrick Walsh developed nerve-sparing radical prostatectomy, which significantly reduced postoperative erectile dysfunction and urinary incontinence [19]. In 1992, Schuessler et al. performed the first laparoscopic radical prostatectomy (LRP), which offered advantages such as reduced blood loss and faster recovery [20]. However, the learning curve was prolonged, and Neurovascular Bundle (NVB) preservation proved challenging because of the limitations of 2D visualization and restricted instrument maneuverability [21]. In 2000, Dr. Mani Menon performed the first da Vinci robot-assisted radical prostatectomy (RARP), ushering in a new era of precision in prostate cancer surgery that has shown clinical effectiveness in reducing complications and improving outcomes [22].
The anterior approach (access to the Retzius space) has recently become the standard of care approach for RARP. However, modified techniques, such as the posterior approach (Retzius-sparing) and the Hood technique, aimed at maximizing the recovery of urinary continence and sexual function, are gaining attention [10,12,23]. Single-port robotic systems are the latest innovations seeking to minimize the number of ports or incisions used while retaining the established benefits of RARP [14,15,16].

3. A Spectrum of Surgical Approaches in Robot-Assisted Radical Prostatectomy: Standard, Hood, Lateral, and Retzius-Sparing Techniques

3.1. Standard (Anterior) RARP and Its Refinements

When performing nerve-sparing robot-assisted radical prostatectomy (RARP) via the anterior route, surgeons typically incise the endopelvic fascia and enter the Retzius space to gain excellent visualization of critical landmarks, including the bladder neck and dorsal venous plexus (Figure 1a). By controlling the dorsal venous complex (DVC) and working sequentially toward the apex, the operator can clip the pedicles precisely and methodically dissect the prostate by controlling the dorsal venous complex and working sequentially toward the apex. Recognizing that neurovascular bundles (NVBs) extend more anteriorly than once presumed, potentially up to the 2 and 10 o’clock positions, Menon and Kaul pioneered the so-called “Veil of Aphrodite” in the mid-2000s [13,24]. Their technique involved meticulous release of the anterolateral prostatic fascia and gentle “peeling” of the NVB off the prostate to preserve a generous veil of tissue, thereby decreasing traction or thermal injury to key nerves [9,24]. Subsequent experience indicated that even greater periurethral coverage might further improve urinary control, prompting additional refinements.
A major series of standard RARP has been documented to have consistent and favorable results. Positive surgical margin (PSM) rates in organ-confined disease (pT2) typically range from ~10–20%, while ~40–60% of patients achieve zero-pad continence at 1–3 months, increasing to ≥85% by 1 year [9,25,26]. Nerve-sparing is performed at the lateral aspects of the prostate to preserve erectile function, with approximately 50–70% of men recovering adequate erections if the preoperative function is normal [27]. Surgeons adopt either an interfascial plane (partial nerve-sparing) or an intrafascial plane (aggressive nerve-sparing) based on preoperative risk and MRI findings [5].

3.2. Hood Techniques

Building on the basic anterior approach, Wagaskar et al. recently described the “Hood” technique [10]. This approach extends the high anterior release such that a broader cuff of fascia is preserved near the external sphincter, effectively creating a “hood-like” tissue shield at the prostate apex (Figure 1b). By shifting the anterior boundary of the dissection more proximally, the Hood technique guards the additional anterior and periurethral neurovascular fibers while maintaining oncological safety. The impetus is to maintain a robust hammock of the membranous urethra, potentially improving early continence. In a large single-center series, hood-sparing RARP achieved ~80% dryness at 1 month and ~90% dryness at 3 months with minimal impact on margin rates [10]. Some believe that the hood-sparing approach further complements meticulous nerve sparing by ensuring that the apical dissection remains close to the prostate capsule while leaving intact periurethral support. As a result, “hood technique” data show 6–16% PSM rates in pT2 disease [10,11,28]. The transition from standard to hood-sparing RARP is anatomically straightforward for surgeons who are already comfortable with the anterior approach. While Retzius sparing (described below) requires a posterior route, the hood technique simply modifies the standard anterior route by limiting the wide mobilization of retropubic structures.

3.3. Lateral Approach

When performing nerve-sparing robot-assisted radical prostatectomy (RARP) via the lateral route, surgeons typically proceed medially toward the prostate base and apex [29,30,31]. Early anatomical studies revealed that approximately 20–25% of periprostatic nerves lie closer to the ventral and lateral aspects of the prostatic capsule, highlighting the potential advantage of a lateral dissection to optimize nerve preservation [32].
From a technical standpoint, the lateral approach can be more challenging for surgeons primarily trained in anterior or posterior approaches. However, it can preserve the anterior pubovesical complex (dorsal vein complex, puboprostatic ligaments) by avoiding wide mobilization of the retropubic space, potentially accelerating early continence. Rodríguez Socarrás et al. found that ~85–86% of patients in a large (n = 513) cohort achieved immediate continence, with PSM rates of 33–38% in organ-confined disease [29]. A single-surgeon experience in 70 patients by Giulioni et al. reported a 15% PSM rate, 81% continence at 6 weeks (rising to 94% by 12 months), and an 84% potency rate at 1 year [30]. Nonetheless, as these authors note, a steep learning curve remains a concern, especially in higher-BMI patients or those with large prostates.
Overall, the lateral approach appears to balance effective oncological control with robust nerve-sparing for urinary and sexual function. Additional randomized studies are needed to clarify its long-term benefits relative to standard or Retzius-sparing approaches, but current evidence suggests it may serve as an alternative or complementary method in specialized centers [30,31].

3.4. Retzius-Sparing (Posterior) Access

In 2010, Bocciardi et al. (and subsequently Galfano et al.) popularized the concept of a Retzius-sparing approach to maintain the entire anterior compartment (puboprostatic ligaments, dorsal vein complex, and endopelvic fascia) intact [12,23]. This approach involved incising the peritoneum posteriorly near the cul-de-sac behind the bladder, exposing the seminal vesicles first, and then working antegrade along the prostatic capsule. The apex was dissected in a reversed orientation, culminating in a vesicourethral anastomosis without disturbing the retropubic space (Figure 1c) [12,23,33].
The reported functional benefit is an earlier return to continence because normal anatomic support for the sphincter is not disrupted [23,34]. Several prospective or randomized series have confirmed approximately 65–80% immediate or 1-week dryness, surpassing typical anterior results [33,34,35]. These differences narrow at 12 months, with many studies reporting that standard and Retzius-sparing outcomes converge. There are contradictory reports suggesting the possibly higher PSM rates in advanced or anteriorly located tumors, presumably because apical dissection under a reversed angle can be challenging [12,33,34]. Nonetheless, a large series from experienced centers showed that Retzius-sparing can be safely performed for low-to intermediate-risk disease with no deterioration in mid-term oncological endpoints [33,36].
This posterior approach is conceptually more demanding for surgeons trained in anterior RARP and can be less intuitive in handling large median lobes or advanced T3 lesions. Some surgeons prefer Retzius-sparing, primarily in cases where early continence is paramount, and tumor extension is not suspected near the apex or anterior region [12,33,34].

4. Optimizing Functional Recovery: Bladder Neck, Urethral, and ARVUS Techniques

While significant progress has been made with refined surgical techniques, post-prostatectomy incontinence remains a persistent challenge. In response, further innovations have focused on preserving the bladder neck, maximizing functional urethral length, and employing advanced reconstructions such as the Advanced Reconstruction of Vesicourethral Support (ARVUS) method. These strategies are designed to expedite early urinary continence by safeguarding or restoring the critical pelvic support structures that underlie sphincter function.

4.1. Bladder Neck Preservation (BNP)

Bladder neck preservation involves careful dissection around the prostate base, sparing as much of the bladder neck musculature as possible. By maintaining the native circular fibers of the bladder neck, surgeons aim to preserve an essential component of urinary continence. Meta-analyses of both open and minimally invasive series suggest that BNP significantly reduces time to continence, with improvements in 1-week and 1-month pad-free rates [24,25,34,35]. This approach can be anatomically challenging, particularly in patients with larger glands or complex apical disease, yet when feasible, it may hasten continence recovery without negatively impacting cancer control. Surgeons must balance the risk of leaving residual prostatic tissue if the dissection is overly conservative, emphasizing the importance of preoperative imaging and careful patient selection [24,25].

4.2. Urethral Preservation

In parallel with BNP, several centers emphasize maximal urethral preservation—particularly near the prostatic apex—to preserve the intrinsic sphincter and length of the membranous urethra [10,23,36]. Prostate apex dissection carried out too far distally may shorten the urethra or disrupt the rhabdosphincter complex, delaying continence. Conversely, a carefully executed apex release (e.g., “peeling off” the apex at the correct plane, with the dorsal venous complex individually suture-ligated or selectively controlled) can maximize functional urethral length. Preliminary data suggest that such approaches yield a higher proportion of patients with zero-pad or one-pad usage in 1–3 months [27,36,37]. The exact advantage of urethral preservation may depend on the tumor stage, preoperative function, and the surgeon’s ability to maintain adequate margins at the apex.

4.3. The ARVUS Technique

Alongside direct bladder neck and urethral preservation, certain authors advocate specialized reconstructions (e.g., the Advanced Reconstruction of Vesicourethral Support [ARVUS]) to bolster peri-urethral support. ARVUS was originally described by Student et al. as a “semi-circular” or “hammock” reconstruction, in which levator ani fibers, Denonvilliers fascia, and the median dorsal raphe are sutured around the urethrovesical anastomosis [38,39]. This maneuver effectively recreates a dynamic support akin to a sling, restoring normal anatomic relationships that may be lost after prostate removal. Prospective trials and early cohorts have reported improved early continence (up to 40–60% pad-free at 2–4 weeks) and no detrimental effect on surgical margin rates [38,39,40]. Additional validations by Kováčik et al. further confirm that ARVUS does not significantly lengthen operative times while offering robust support for the vesicourethral junction [39].

5. Single-Port RARP and Novel Access Routes

5.1. Rationale and Initial Adoption

Single-port (SP) robotics were introduced to reduce incisional morbidity further and theoretically improve pain control and cosmesis by consolidating all instruments into a single 2–4 cm incision. Single-site laparoscopic radical prostatectomy has been attempted with standard multiarm robots via a single gel port; instrument crossing and suboptimal triangulation are major pitfalls [14,41,42]. The da Vinci SP system (Intuitive Surgical, Sunnyvale, CA, USA) overcomes many of these issues by providing multiple double-jointed instruments that pass coaxially, thereby permitting intra-abdominal articulation [15,16]. SP-RARP can replicate standard- or Retzius-sparing planes. Surgeons can also place the port extraperitoneally, transperitoneally, perineally, or transvesically, each bearing specific advantages and challenges [15,43].

5.2. Extraperitoneal and Transperitoneal Approach

The extraperitoneal approach with the SP helps avoid bowel manipulation and may facilitate a shorter hospital stay. Early cohort studies from Kim et al. and Kaouk et al. reported minimal use of additional ports, short operative times, and safe PSM rates of approximately 20–30% for pT2 disease, with 60–80% dryness at 1–3 months [43,44,45]. Meanwhile, the transperitoneal SP method more closely parallels the standard multiport RARP, albeit channeled through a single umbilical incision. Studies have shown no substantial differences in long-term oncological or functional outcomes relative to multiport RARP, although the learning curve can be steeper if surgeons rely solely on a single cannula for retraction [15,43].

5.3. Transperineal Single-Port

The perineal route with a single-port cannula attempts to replicate the historical perineal open prostatectomy but with robotic articulation. It helps avoid abdominal incisions, which can be beneficial for patients undergoing multiple laparotomies or ostomies. However, a tight operative field may hamper wide or extended pelvic lymph node dissection (ePLND). A small case series from Lenfant et al. and Yu et al. suggested that the approach is feasible but can yield higher PSM rates if not carefully performed [46,47]. Currently, single transperineal port placement remains a niche approach.

5.4. Transvesical Single-Port

Among SP variations, transvesical RARP, popularized by Kaouk et al., Zhou et al., Deng et al., and others, stands out because of its Retzius-sparing properties. Instead of incising the retropubic space, the surgeon places a ~3 cm suprapubic incision, incises the bladder dome by ~2 cm, and “floating-docks” the SP cannula inside the bladder [16,48,49,50]. The vantage point is intravesical; the bladder neck is incised circumferentially, the seminal vesicles reach posteriorly (akin to a posterior approach), and the apex is dissected from the inside of the bladder. The anterior support structures remained undisturbed without opening the retropubic space [16,48].
Some small-to-moderate series showed extremely promising early continence, immediate dryness, or near dryness in up to 80–90% of patients after Foley catheter removal [48,50,51,52]. For instance, Kaouk et al. initially reported a small series of 10 patients who underwent transvesical single-port RARP, most of whom were discharged within 24 h, with minimal pain medication and approximately 50% immediate continence. Deng et al. studied 60 patients with 15% PSM and 90% dryness at removal and noted no major complications or 30-day readmissions [50]. Zhou et al. described 35 patients with 91% immediate continence and a 4/35 PSM rate (11.4%); none of them had biochemical recurrence at early follow-up [51]. In a more recent multi-institutional collaboration, the same group reported consistent findings, although PSM in higher-stage diseases increased. Similarly, Chung et al. documented continence in four patients(100%), although two (50%) had advanced pT3 disease with positive margins [52].
Although the technique yields excellent early functional outcomes, it may be suboptimal for advanced or large-lobe disease owing to the limited working space inside the bladder and the reversed orientation for apex control. Surgeons must also adopt a new technique for pelvic lymph node dissection, as full ePLND is challenging transvesically. Nonetheless, transvesical single-port RARP may be ideal for smaller prostates in patients with prior abdominal surgeries or for those prioritizing a rapid return of continence [48,50,51,52].

6. Clinical Outcomes Across Multiple Approaches: A Comparative Table

Table 1 provides an updated summary table incorporating data from various centers and the column details approach, study sample, approximate pT2 vs. pT3 distribution, positive margin rates, urinary continence (UC) in the short term (commonly 1–3 months), potency if reported, and short-term biochemical recurrence (BCR) references. Because definitions vary (for dryness, some groups use “0 pads”, others “0–1 pad”, etc.), comparisons are approximate.

7. Discussion

Recent advances in radical prostatectomy have led to the development of a diverse array of surgical techniques that aim to maximize oncologic control while improving postoperative quality of life by enhancing urinary continence and sexual function [44,56]. In our review, we describe a spectrum of approaches ranging from the standard anterior robot-assisted radical prostatectomy (RARP) to more complex modifications—including hood-sparing, lateral, Retzius-sparing, and emerging single-port (SP) methods—with each technique offering its own balance of technical demands and potential benefits.
A key consideration is the learning curve associated with each approach. Comparison data indicate that the standard anterior RARP, which uses well-defined anatomical landmarks and allows a straightforward dissection in the Retzius space, has a more gradual learning curve compared to advanced modifications such as lateral or Retzius-sparing techniques [57,58,59,60]. The standard approach is thus particularly suitable for residents and novice surgeons, as it provides a solid foundation of robotic skills and a comprehensive understanding of pelvic anatomy before progressing to more technically challenging methods. In contrast, techniques like Retzius-sparing and hood-sparing RARP, although they may offer improvements in early continence and nerve preservation, demand a steeper learning curve due to their reversed dissection planes and more confined operative fields [58,59]. Consequently, when designing training programs, it is advisable to begin with the standard anterior approach and introduce more advanced techniques only after a baseline proficiency has been achieved.
Operator-dependent factors significantly affect postoperative outcomes. Technical proficiency in nerve-sparing dissection, precise preservation of periurethral support structures, and high cumulative case volume are essential for optimizing urinary continence and erectile function [61,62]. Likewise, patient-dependent factors—including age, body mass index (BMI), prostate size, and tumor stage—are crucial determinants of recovery. For example, patients with obesity or larger prostates may benefit from surgical approaches that reduce tissue trauma and operative time, while those with anterior tumors or advanced disease require meticulous preoperative planning to balance oncologic clearance with functional preservation [60,61].
While robotic technology has dramatically transformed surgical practice over the past 25 years, long-term studies have yet to conclusively demonstrate that RARP offers superior oncologic or functional outcomes compared to open radical prostatectomy [63]. Moreover, emerging alternative treatments—such as stereotactic radiotherapy and focal therapy—are gaining attention because of their potential to cure prostate cancer while minimizing complications like incontinence and erectile dysfunction; however, current evidence remains inconclusive and warrants further investigation [64,65,66]. This underscores the need for additional randomized studies, standardized training protocols, and technological advancements (including improved haptic feedback, augmented reality guidance, and patient-specific surgical planning) to fully realize the benefits of robotic surgery.
In summary, the selection of a surgical approach for radical prostatectomy should be tailored to individual patient characteristics (e.g., obesity, tumor location, and stage) as well as the surgeon’s experience. For novice surgeons, the standard anterior RARP remains the most accessible and recommended initial approach due to its forgiving learning curve and consistent outcomes [57,60]. As experience accumulates, advanced techniques such as Retzius-sparing and hood-sparing approaches can be gradually incorporated to further enhance early functional recovery. Concurrently, individualized reconstruction strategies—including bladder neck and urethral preservation with methods such as ARVUS—are essential for optimizing outcomes in patients with complex pelvic anatomies [60,61]. Ultimately, although robotic surgery has advanced considerably, its long-term advantages over open radical prostatectomy have yet to be definitively proven, emphasizing the need for continued comparative research, enhanced surgical training, and integration of emerging technologies.

8. Conclusions

The evolution of radical prostatectomy—from open surgery to diverse robot-assisted techniques—reflects a sustained effort to balance oncologic efficacy with quality-of-life preservation. While modified approaches such as hood-sparing, lateral, and Retzius-sparing RARP show promise in enhancing early functional recovery, they require higher technical expertise and have steeper learning curves. The standard anterior RARP remains the recommended initial approach for residents and novice surgeons, providing a solid foundation for the future adoption of advanced techniques. Future research should emphasize comparative outcomes, refinement of training protocols, and the incorporation of innovative technologies to further individualize treatment and improve both oncologic and functional outcomes.

Author Contributions

Conceptualization; methodology; validation; formal analysis; investigation; data curation; writing—original draft preparation; writing—review and editing; visualization: S.B.J. Conceptualization; methodology; validation; resources; writing—review and editing; supervision; project administration; writing—review and editing: J.W.K. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Conflicts of Interest

The authors declare no conflicts of interest.

Abbreviations

The following abbreviations are used in this manuscript:
DVCDorsal venous complex
LRPLaparoscopic radical prostatectomy
PSMPositive surgical margin
RARPRobot-assisted radical prostatectomy
RPRadical prostatectomy
SPSingle-port
UCUrinary continence

References

  1. American Cancer Society. Key Statistics for Prostate Cancer. Available online: https://www.cancer.org/cancer/types/prostate-cancer/about/key-statistics.html (accessed on 23 January 2025).
  2. Sung, H.; Ferlay, J.; Siegel, R.L.; Laversanne, M.; Soerjomataram, I.; Jemal, A.; Bray, F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J. Clin. 2021, 71, 209–249. [Google Scholar] [CrossRef] [PubMed]
  3. Siegel, R.L.; Miller, K.D.; Wagle, N.S.; Jemal, A. Cancer Statistics, 2023. CA Cancer J. Clin 2023, 73, 17–48. [Google Scholar] [CrossRef] [PubMed]
  4. Schuessler, W.W.; Schulam, P.G.; Clayman, R.V.; Kavoussi, L.R. Laparoscopic radical prostatectomy: Initial short-term experience. Urology 1997, 50, 854–857. [Google Scholar] [CrossRef] [PubMed]
  5. Ficarra, V.; Novara, G.; Artibani, W.; Cestari, A.; Galfano, A.; Graefen, M.; Guazzoni, G.; Guillonneau, B.; Menon, M.; Montorsi, F. Retropubic, Laparoscopic, and Robot-Assisted Radical Prostatectomy: A Systematic Review and Cumulative Analysis of Comparative Studies. Eur. Urol. 2009, 55, 1037–1063. [Google Scholar] [CrossRef]
  6. Hu, J.C.; Gu, X.; Lipsitz, S.R.; Barry, M.J.; D’amico, A.V.; Weinberg, A.C.; Keating, N.L. Comparative Effectiveness of Minimally Invasive vs Open Radical Prostatectomy. Jama 2009, 302, 1557–1564. [Google Scholar] [CrossRef]
  7. Bi, J.; Er, N.D.; Am, R. Robotically-Assisted Laparoscopic Radical Prostatectomy. BJU Int. 2001, 87, 408–410. [Google Scholar]
  8. Coughlin, G.D.; Yaxley, J.W.; Chambers, S.K.; Occhipinti, S.; Samaratunga, H.; Zajdlewicz, L.; Teloken, P.; Dunglison, N.; Williams, S.; Lavin, M.F.; et al. Robot-Assisted Laparoscopic Prostatectomy versus Open Radical Retropubic Prostatectomy: 24-Month Outcomes from a Randomised Controlled Study. Lancet Oncol. 2018, 19, 1051–1060. [Google Scholar] [CrossRef]
  9. Patel, V.R.; Tully, A.S.; Holmes, R.; Lindsay, J. Robotic Radical Prostatectomy in the Community Setting—The Learning Curve and beyond: Initial. 200 Cases. J. Urol. 2005, 174, 269–272. [Google Scholar] [CrossRef]
  10. Wagaskar, V.G.; Mittal, A.; Sobotka, S.; Ratnani, P.; Lantz, A.; Falagario, U.G.; Martini, A.; Dovey, Z.; Treacy, P.J.; Pathak, P.; et al. Hood Technique for Robotic Radical Prostatectomy—Preserving Periurethral Anatomical Structures in the Space of Retzius and Sparing the Pouch of Douglas, Enabling Early Return of Continence Without Compromising Surgical Margin Rates. Eur. Urol. 2021, 80, 213–221. [Google Scholar] [CrossRef]
  11. Shimmura, H.; Banno, T.; Nakamura, K.; Murayama, A.; Shigeta, H.; Sawano, T.; Kouchi, Y.; Ozaki, A.; Yamabe, F.; Iizuka, J.; et al. A Single-Center Retrospective Comparative Analysis of Urinary Continence in Robotic Prostatectomy with a Combination of Umbilical Ligament Preservation and Hood Technique. Int. J. Urol. 2023, 30, 889–895. [Google Scholar] [CrossRef]
  12. Galfano, A.; Ascione, A.; Grimaldi, S.; Petralia, G.; Strada, E.; Bocciardi, A.M. A New Anatomic Approach for Robot-Assisted Laparoscopic Prostatectomy: A Feasibility Study for Completely Intrafascial Surgery. Eur. Urol. 2010, 58, 457–461. [Google Scholar] [CrossRef] [PubMed]
  13. Kaul, S.; Savera, A.; Badani, K.; Fumo, M.; Bhandari, A.; Menon, M. Functional Outcomes and Oncological Efficacy of Vattikuti Institute Prostatectomy with Veil of Aphrodite Nerve-Sparing: An Analysis of 154 Consecutive Patients. BJU Int. 2006, 97, 467–472. [Google Scholar] [CrossRef]
  14. Dobbs, R.W.; Halgrimson, W.R.; Madueke, I.; Vigneswaran, H.T.; Wilson, J.O.; Crivellaro, S. Single-Port Robot-Assisted Laparoscopic Radical Prostatectomy: Initial Experience and Technique with the Da Vinci® SP Platform. BJU Int. 2019, 124, 1022–1027. [Google Scholar] [CrossRef] [PubMed]
  15. Agarwal, D.K.; Sharma, V.; Toussi, A.; Viers, B.R.; Tollefson, M.K.; Gettman, M.T.; Frank, I. Initial Experience with Da Vinci Single-Port Robot-Assisted Radical Prostatectomies. Eur. Urol. 2020, 77, 373–379. [Google Scholar] [CrossRef] [PubMed]
  16. Kaouk, J.H.; Haber, G.P.; Autorino, R.; Crouzet, S.; Ouzzane, A.; Flamand, V.; Villers, A. A Novel Robotic System for Single-Port Urologic Surgery: First Clinical Investigation. Eur. Urol. 2014, 66, 1033–1043. [Google Scholar] [CrossRef]
  17. Young, H.H. The Early Diagnosis and Radical Cure of Carcinoma of the Prostate.: Being a Study of 40 Cases and Presentation of a Radical Operation Which Was Carried out in Four Cases. J. Urol. 2002, 168, 914–921. [Google Scholar] [CrossRef]
  18. Millin, T. Retropubic Urinary Surgery; E. & S. Livingstone: Edinburgh, UK, 1948. [Google Scholar]
  19. Lepor, H.; Gregerman, M.; Crosby, R.; Mostofi, F.K.; Walsh, P.C. Precise Localization of the Autonomic Nerves from the Pelvic Plexus to the Corpora Cavernosa: A Detailed Anatomical Study of the Adult Male Pelvis. J. Urol. 1985, 133, 207–212. [Google Scholar] [CrossRef]
  20. Schuessler, W.W. Laparoscopic Redical Prostatectomy: Initial Case Report. J. Urol. 1992, 147, 246A. [Google Scholar]
  21. Guillonneau, B.; Vallancien, G. Laparoscopic Radical Prostatectomy: The Montsouris Experience. J. Urol. 2000, 163, 418–422. [Google Scholar] [CrossRef]
  22. Pasticier, G.; Rietbergen, J.B.W.; Guillonneau, B.; Fromont, G.; Menon, M.; Vallancien, G. Robotically Assisted Laparoscopic Radical Prostatectomy: Feasibility Study in Men. Eur. Urol. 2001, 40, 70–74. [Google Scholar] [CrossRef]
  23. Galfano, A.; Di Trapani, D.; Sozzi, F.; Strada, E.; Petralia, G.; Bramerio, M.; Ascione, A.; Gambacorta, M.; Bocciardi, A.M. Beyond the Learning Curve of the Retzius-Sparing Approach for Robot-Assisted Laparoscopic Radical Prostatectomy: Oncologic and Functional Results of the First 200 Patients with ≥1 Year of Follow-Up. Eur. Urol. 2013, 64, 974–980. [Google Scholar] [CrossRef] [PubMed]
  24. Kaul, S.; Menon, M. Robotic Radical Prostatectomy: Evolution from Conventional to VIP. World J. Urol. 2006, 24, 152–160. [Google Scholar] [CrossRef] [PubMed]
  25. Link, B.A.; Nelson, R.; Josephson, D.Y.; Yoshida, J.S.; Crocitto, L.E.; Kawachi, M.H.; Wilson, T.G. The Impact of Prostate Gland Weight in Robot Assisted Laparoscopic Radical Prostatectomy. J. Urol. 2008, 180, 928–932. [Google Scholar] [CrossRef] [PubMed]
  26. Coelho, R.F.; Chauhan, S.; Palmer, K.J.; Rocco, B.; Patel, M.B.; Patel, V.R. Robotic-assisted Radical Prostatectomy: A Review of Current Outcomes. BJU Int. 2009, 104, 1428–1435. [Google Scholar] [CrossRef]
  27. Sood, A.; Abdollah, F.; Menon, M. Retzius-Sparing Robot-Assisted Radical Prostatectomy. BJU Int. 2019, 123, 7–8. [Google Scholar] [CrossRef]
  28. Kaye, D.R.; Hyndman, M.E.; Segal, R.L.; Mettee, L.Z.; Trock, B.J.; Feng, Z.; Su, L.M.; Bivalacqua, T.J.; Pavlovich, C.P. Urinary Outcomes Are Significantly Affected by Nerve Sparing Quality during Radical Prostatectomy. Urology 2013, 82, 1348–1354. [Google Scholar] [CrossRef]
  29. Rodríguez Socarrás, M.; Gómez Rivas, J.; Reinoso Elbers, J.; Espósito, F.; Llanes Gonzalez, L.; Monsalve, D.M.C.; Fernandez Del Alamo, J.; Ruiz Graña, S.; Juarez Varela, J.; Coria, D.; et al. Robot-Assisted Radical Prostatectomy by Lateral Approach: Technique, Reproducibility and Outcomes. Cancers 2023, 15, 5442. [Google Scholar] [CrossRef]
  30. Giulioni, C.; Castellani, D.; Vuong, N.S.; Riviere, J.; Piechaud-Kressmann, J.; Lopez, L.H.; Piechaud, T.; Roche, J.B.; Rouffilange, J.; Hoepffner, J.L.; et al. Outcomes of Lateral Approach in Robot-Assisted Radical Prostatectomy: Insights from a Single-Surgeon Experience. J. Robot. Surg. 2024, 18, 27. [Google Scholar] [CrossRef]
  31. Asimakopoulos, A.D.; Mugnier, C.; Hoepffner, J.L.; Piechaud, T.; Gaston, R. Surgery Illustrated Focus on Details Bladder Neck Preservation during Minimally Invasive Radical Prostatectomy: A Standardised Technique Using a Lateral Approach. BJU Int. 2012, 110, 1566–1571. [Google Scholar] [CrossRef]
  32. Eichelberg, C.; Erbersdobler, A.; Michl, U.; Schlomm, T.; Salomon, G.; Graefen, M.; Huland, H. Nerve Distribution along the Prostatic Capsule. Eur. Urol. 2007, 51, 105–111. [Google Scholar] [CrossRef]
  33. Dalela, D.; Jeong, W.; Prasad, M.A.; Sood, A.; Abdollah, F.; Diaz, M.; Karabon, P.; Sammon, J.; Jamil, M.; Baize, B.; et al. A Pragmatic Randomized Controlled Trial Examining the Impact of the Retzius-Sparing Approach on Early Urinary Continence Recovery After Robot-Assisted Radical Prostatectomy. Eur. Urol. 2017, 72, 677–685. [Google Scholar] [CrossRef] [PubMed]
  34. Barakat, B.; Othman, H.; Gauger, U.; Wolff, I.; Hadaschik, B.; Rehme, C. Retzius Sparing Radical Prostatectomy Versus Robot-Assisted Radical Prostatectomy: Which Technique Is More Beneficial for Prostate Cancer Patients (MASTER Study)? A Systematic Review and Meta-Analysis. Eur. Urol. Focus. 2022, 8, 1060–1071. [Google Scholar] [CrossRef] [PubMed]
  35. Egan, J.; Marhamati, S.; Carvalho, F.L.F.; Davis, M.; O’Neill, J.; Lee, H.; Lynch, J.H.; Hankins, R.A.; Hu, J.C.; Kowalczyk, K.J. Retzius-Sparing Robot-Assisted Radical Prostatectomy Leads to Durable Improvement in Urinary Function and Quality of Life Versus Standard Robot-Assisted Radical Prostatectomy Without Compromise on Oncologic Efficacy: Single-Surgeon Series and Step-by-Step Guide. Eur. Urol. 2021, 79, 839–857. [Google Scholar] [CrossRef] [PubMed]
  36. Qiu, X.; Li, Y.; Chen, M.; Xu, L.; Guo, S.; Marra, G.; Elliot Rosenberg, J.; Ma, H.; Li, X.; Guo, H. Retzius-Sparing Robot-Assisted Radical Prostatectomy Improves Early Recovery of Urinary Continence: A Randomized, Controlled, Single-Blind Trial with a 1-Year Follow-Up. BJU Int. 2020, 126, 633–640. [Google Scholar] [CrossRef]
  37. Hikita, K.; Honda, M.; Shimizu, R.; Nishikawa, R.; Teraoka, S.; Kimura, Y.; Yamaguchi, N.; Iwamoto, H.; Morizane, S.; Takenaka, A. Advanced Reconstruction of Vesicourethral Support May Improve Urinary Continence and Quality of Life After Non-Nerve-Sparing Robot-Assisted Radical Prostatectomy. In Vivo 2023, 37, 371–377. [Google Scholar] [CrossRef]
  38. Student, V.; Vidlar, A.; Grepl, M.; Hartmann, I.; Buresova, E.; Student, V. Advanced Reconstruction of Vesicourethral Support (ARVUS) during Robot-Assisted Radical Prostatectomy: One-Year Functional Outcomes in a Two-Group Randomised Controlled Trial. Eur. Urol. 2017, 71, 822–830. [Google Scholar] [CrossRef]
  39. Kováčik, V.; Maciak, M.; Baláž, V.; Babeľa, J.; Kubas, V.; Bujdák, P.; Beňo, P. Advanced Reconstruction of Vesicourethral Support (ARVUS) during Robot-Assisted Radical Prostatectomy: First Independent Evaluation and Review of Other Factors Influencing 1 Year Continence Outcomes. World J. Urol. 2020, 38, 1933–1941. [Google Scholar] [CrossRef]
  40. Hoeh, B.; Hohenhorst, J.L.; Wenzel, M.; Humke, C.; Preisser, F.; Wittler, C.; Brand, M.; Köllermann, J.; Steuber, T.; Graefen, M.; et al. Full Functional-Length Urethral Sphincter- and Neurovascular Bundle Preservation Improves Long-Term Continence Rates after Robotic-Assisted Radical Prostatectomy. J. Robot. Surg. 2023, 17, 177–184. [Google Scholar] [CrossRef]
  41. Noh, T.I.; Kang, Y.J.; Shim, J.S.; Kang, S.H.; Cheon, J.; Lee, J.G.; Kang, S.G. Single-Port vs Multiport Robot-Assisted Radical Prostatectomy: A Propensity Score Matching Comparative Study. J. Endourol. 2022, 36, 661–667. [Google Scholar] [CrossRef]
  42. White, M.A.; Haber, G.P.; Autorino, R.; Khanna, R.; Forest, S.; Yang, B.; Altunrende, F.; Stein, R.J.; Kaouk, J.H. Robotic Laparoendoscopic Single-Site Radical Prostatectomy: Technique and Early Outcomes. Eur. Urol. 2010, 58, 544–550. [Google Scholar] [CrossRef]
  43. Abou Zeinab, M.; Beksac, A.T.; Ferguson, E.; Kaviani, A.; Moschovas, M.C.; Joseph, J.; Kim, M.; Crivellaro, S.; Nix, J.; Patel, V.; et al. Single-Port Extraperitoneal and Transperitoneal Radical Prostatectomy: A Multi-Institutional Propensity-Score Matched Study. Urology 2023, 171, 140–145. [Google Scholar] [CrossRef] [PubMed]
  44. Kim, J.E.; Kaldany, A.; Lichtbroun, B.; Singer, E.A.; Jang, T.L.; Ghodoussipour, S.; Kim, M.M.; Kim, I.Y. Single-Port Robotic Radical Prostatectomy: Short-Term Outcomes and Learning Curve. J. Endourol. 2022, 36, 1285–1289. [Google Scholar] [CrossRef] [PubMed]
  45. Kaouk, J.; Valero, R.; Sawczyn, G.; Garisto, J. Extraperitoneal Single-Port Robot-Assisted Radical Prostatectomy: Initial Experience and Description of Technique. BJU Int. 2020, 125, 182–189. [Google Scholar] [CrossRef] [PubMed]
  46. Yu, C.; Xu, L.; Ye, L.; Zheng, Q.; Hu, H.; Ni, K.; Zhou, C.; Xue, D.; Cheng, S.; Wang, H.; et al. Single-Port Robot-Assisted Perineal Radical Prostatectomy with the Da Vinci XI System: Initial Experience and Learning Curve Using the Cumulative Sum Method. World J. Surg. Oncol. 2023, 21, 46. [Google Scholar] [CrossRef]
  47. Lenfant, L.; Garisto, J.; Sawczyn, G.; Wilson, C.A.; Aminsharifi, A.; Kim, S.; Schwen, Z.; Bertolo, R.; Kaouk, J. Robot-Assisted Radical Prostatectomy Using Single-Port Perineal Approach: Technique and Single-Surgeon Matched-Paired Comparative Outcomes. Eur. Urol. 2021, 79, 384–392. [Google Scholar] [CrossRef]
  48. Ramos-Carpinteyro, R.; Ferguson, E.L.; Chavali, J.S.; Geskin, A.; Kaouk, J. First 100 Cases of Transvesical Single-Port Robotic Radical Prostatectomy. Asian J. Urol. 2023, 10, 416–422. [Google Scholar] [CrossRef]
  49. Ramos-Carpinteyro, R.; Ferguson, E.L.; Chavali, J.S.; Geskin, A.; Soputro, N.; Kaouk, J. Single-Port Transvesical Robot-Assisted Radical Prostatectomy: The Surgical Learning Curve of the First 100 Cases. Urology 2023, 178, 76–82. [Google Scholar] [CrossRef]
  50. Deng, W.; Jiang, H.; Liu, X.; Chen, L.; Liu, W.; Zhang, C.; Zhou, X.; Fu, B.; Wang, G. Transvesical Retzius-Sparing Versus Standard Robot-Assisted Radical Prostatectomy: A Retrospective Propensity Score-Adjusted Analysis. Front. Oncol. 2021, 11, 687010. [Google Scholar] [CrossRef]
  51. Zhou, X.; Fu, B.; Zhang, C.; Liu, W.; Guo, J.; Chen, L.; Lei, E.; Zhang, X.; Wang, G. Transvesical Robot-Assisted Radical Prostatectomy: Initial Experience and Surgical Outcomes. BJU Int. 2020, 126, 300–308. [Google Scholar] [CrossRef]
  52. Chung, J.H.; Kim, H.; Bang, W.J.; Oh, C.Y.; Cho, J.S. Early Experience of the Single-Port Robotic Transvesical Radical Prostatectomy: Case Series. J. Urol. Oncol. 2024, 22, 188–195. [Google Scholar] [CrossRef]
  53. Menon, M.; Shrivastava, A.; Bhandari, M.; Satyanarayana, R.; Siva, S.; Agarwal, P.K. Vattikuti Institute Prostatectomy: Technical Modifications in 2009. Eur. Urol. 2009, 56, 89–96. [Google Scholar] [CrossRef] [PubMed]
  54. Patel, V.R.; Abdul-Muhsin, H.M.; Schatloff, O.; Coelho, R.F.; Valero, R.; Ko, Y.H.; Sivaraman, A.; Palmer, K.J.; Chauhan, S. Critical Review of “pentafecta” Outcomes after Robot-Assisted Laparoscopic Prostatectomy in High-Volume Centres. BJU Int. 2011, 108, 1007–1017. [Google Scholar] [CrossRef] [PubMed]
  55. Abou Zeinab, M.; Beksac, A.T.; Ferguson, E.; Kaviani, A.; Kaouk, J. Transvesical versus Extraperitoneal Single-Port Robotic Radical Prostatectomy: A Matched-Pair Analysis. World J. Urol. 2022, 40, 2001–2008. [Google Scholar] [CrossRef] [PubMed]
  56. Checcucci, E.; Veccia, A.; Fiori, C.; Amparore, D.; Manfredi, M.; Di Dio, M.; Morra, I.; Galfano, A.; Autorino, R.; Bocciardi, A.M.; et al. Retzius-Sparing Robot-Assisted Radical Prostatectomy vs the Standard Approach: A Systematic Review and Analysis of Comparative Outcomes. BJU Int. 2020, 125, 8–16. [Google Scholar] [CrossRef]
  57. Anceschi, U.; Morelli, M.; Flammia, R.S.; Brassetti, A.; Dell’oglio, P.; Galfano, A.; Tappero, S.; Vecchio, E.; Martiriggiano, M.; Luciani, L.G.; et al. Predictors of Trainees’ Proficiency during the Learning Curve of Robot-Assisted Radical Prostatectomy at High--Volume Institutions: Results from a Multicentric Series. Cent. Eur. J. Urol. 2023, 76, 38–43. [Google Scholar] [CrossRef]
  58. Lovegrove, C.; Novara, G.; Mottrie, A.; Guru, K.A.; Brown, M.; Challacombe, B.; Popert, R.; Raza, J.; Van Der Poel, H.; Peabody, J.; et al. Structured and Modular Training Pathway for Robot-Assisted Radical Prostatectomy (RARP): Validation of the RARP Assessment Score and Learning Curve Assessment. Eur. Urol. 2016, 69, 526–535. [Google Scholar] [CrossRef]
  59. Olivero, A.; Galfano, A.; Piccinelli, M.; Secco, S.; Di Trapani, D.; Petralia, G.; Strada, E.; Barbieri, M.; Napoli, G.; Bocciardi, A.M. Retzius-Sparing Robotic Radical Prostatectomy for Surgeons in the Learning Curve: A Propensity Score–Matching Analysis. Eur. Urol. Focus. 2021, 7, 772–778. [Google Scholar] [CrossRef]
  60. Kato, D.; Namiki, S.; Ueda, S.; Takeuchi, Y.; Takeuchi, S.; Kawase, M.; Kawase, K.; Nakai, C.; Takai, M.; Iinuma, K.; et al. Validation of Standardized Training System for Robot-Assisted Radical Prostatectomy: Comparison of Perioperative and Surgical Outcomes between Experienced Surgeons and Novice Surgeons at a Low-Volume Institute in Japan. Minim. Invasive Ther. Allied Technol. 2022, 31, 1103–1111. [Google Scholar] [CrossRef]
  61. Carlos, A.F.; Dario, V.M.; Popescu, R.I.; Mariela, C.; Venancio, C.A. Robot-Assisted Radical Prostatectomy (RARP) Trifecta Learning Curve for Surgeons with Previous Experience in Laparoscopy. Medicina 2024, 60, 1032. [Google Scholar] [CrossRef]
  62. Fonseca, J.; Froes, G.; Moraes-Fontes, M.F.; Rebola, J.; Lúcio, R.; Almeida, M.; Muresan, C.; Palmas, A.; Gaivão, A.; Matos, C.; et al. Urinary Continence Recovery after Retzius-Sparing Robot-Assisted Radical Prostatectomy in Relation to Surgeon Experience. J. Robot. Surg. 2023, 17, 2503–2511. [Google Scholar] [CrossRef]
  63. Davis, J.W.; Kreaden, U.S.; Gabbert, J.; Thomas, R. Learning Curve Assessment of Robot-Assisted Radical Prostatectomy Compared with Open-Surgery Controls from the Premier Perspective Database. J. Endourol. 2014, 28, 560–566. [Google Scholar] [CrossRef] [PubMed]
  64. Bedi, N.; Reddy, D.; Ahmed, H.U. Targeting the Cancer Lesion, Not the Whole Prostate. Transl. Androl. Urol. 2020, 9, 1518–1525. [Google Scholar] [CrossRef] [PubMed]
  65. Wallis, C.J.D.; Saskin, R.; Choo, R.; Herschorn, S.; Kodama, R.T.; Satkunasivam, R.; Shah, P.S.; Danjoux, C.; Nam, R.K. Surgery Versus Radiotherapy for Clinically-Localized Prostate Cancer: A Systematic Review and Meta-Analysis. Eur. Urol. 2016, 70, 21–30. [Google Scholar] [CrossRef] [PubMed]
  66. Fallara, G.; Capogrosso, P.; Maggio, P.; Taborelli, A.; Montorsi, F.; Dehò, F.; Salonia, A. Erectile Function after Focal Therapy for Localized Prostate Cancer: A Systematic Review. Int. J. Impot. Res. 2021, 33, 418–427. [Google Scholar] [CrossRef]
Figure 1. (a) Conventional (anterior) approach: illustration showing a standard anterior route that begins with incising the endopelvic fascia and entering the retropubic (Retzius) space. This straightforward orientation directly visualizes the bladder neck, apex, and associated neurovascular structures. (b) Hood technique (anterior) depiction of an anterior approach that extends the dissection plane more proximally, preserving a broader fascial cuff around the external sphincter. This “hood” of tissue aims to optimize periurethral support, potentially enhancing early continence and maintaining oncologic safety by sparing key neurovascular fibers. (c) Retzius-sparing (posterior) approach: diagram illustrating a posterior route where the retropubic (Retzius) space remains intact, leaving the dorsal venous plexus, puboprostatic ligaments, and endopelvic fascia undisturbed. Dissection continues behind the bladder in a reversed orientation toward the prostate apex by preserving critical anterior support structures.
Figure 1. (a) Conventional (anterior) approach: illustration showing a standard anterior route that begins with incising the endopelvic fascia and entering the retropubic (Retzius) space. This straightforward orientation directly visualizes the bladder neck, apex, and associated neurovascular structures. (b) Hood technique (anterior) depiction of an anterior approach that extends the dissection plane more proximally, preserving a broader fascial cuff around the external sphincter. This “hood” of tissue aims to optimize periurethral support, potentially enhancing early continence and maintaining oncologic safety by sparing key neurovascular fibers. (c) Retzius-sparing (posterior) approach: diagram illustrating a posterior route where the retropubic (Retzius) space remains intact, leaving the dorsal venous plexus, puboprostatic ligaments, and endopelvic fascia undisturbed. Dissection continues behind the bladder in a reversed orientation toward the prostate apex by preserving critical anterior support structures.
Cancers 17 00902 g001
Table 1. Summary of clinical outcomes by RARP approaches.
Table 1. Summary of clinical outcomes by RARP approaches.
ApproachStudy (Year)NStage pT2/pT3 (%)PSM (%)Early ContinencePotency (≥6 mo)BCR or PSANotes
Standard (Anterior)Ficarra et al. (2009) [5]4000+Mixed10–20 (pT2)~40–60% at 1–3 mo ~50–70% vary.~5–10% at 1–2 ySystematic review comparing laparoscopic/robotic vs. open.
Menon et al. (2009) [53]1100~80/2015–2045–55% at 1 mo, ~90% at 1 y~70–75% at 12 mo~5–8%“Veil of Aphrodite” pioneer.
Patel et al. (2011) [54] 4000~76.2/22.910.8% (overall)67.7% at 6 wk, 85.4% at 3 mo91.5% at 1 y9.5% at 12 moMulti-institutional study; reports pentafecta outcomes.
Hood-SparingWagaskar et al. (2021) [10] 300~75/25680% at 1 mo,
91% at 3 mo
~70–80% (1 y)~5% shortHood technique preserves periurethral structures.
Shimmura et al. (2023) [11] 42~70/301669% at 1 mo,
91% at 3 mo
Not precisely statedNot reportedUmbilical lig. + Hood; small single-center.
Retzius-Sparing
(Posterior)
Galfano et al. (2013) [23] 200~80/2015–2070–80% immediate to 1 mo~65–75% at 1 y~5–6%Pioneer posterior approach.
Dalela et al. (2017) [33]10085/151871% vs. 47% (std) at 1 mo~70% at 1 y5–6% ~1 yPragmatic RCT favoring RS for early continence.
Egan et al. (2021) [35]7080/2034.395% dryness at 1 y65.7% at 1 y~4–5%Possibly advanced disease.
LateralRodríguez Socarrás et al. (2023) [29]513~70/30 33–38 ~85–86% immediate drynessNot reportedNot reported Large cohort; good short-term UC; steep learning curve.
Giulioni et al. (2024) [30]70~60/40 1581% dryness at 6 wk, 94% at 1 y84% at 1 y Not reportedSingle-surgeon experience; stable PSM .
Single-Port (SP)
(Transvesical)Deng et al. (2021) [50]6090/101590% dryness at removal60–70% at 3–6 mo~5% BCR at 12 monthTransvesical retzius-sparing advantage.
Zhou et al. (2020) [51]3580/2011.491% immediate in smaller series~65–70% 3–6 moNo BCR shortNo recurrences short term.
Chung et al. (2024) [52]450/5050100% continence at removal, safety pad at 1 moNot measured fully1 persistent PSAVery small case series; 2 advanced diseases.
Ramos-Carpinteyro (2023) [48]100~80/20~20?80–90% immediate dryness~65–70% (≥6 mo)Not fully statedFirst 100 transvesical SP cases from a single center.
(Extraperitoneal) Abou Zeinab et al. (2023) [55]238~75/25~29 (EP)70% dryness at 1 mo (extraperitoneal)~60–65% potency~9% BCR shortLarge multi-institution EP vs. TP matched.
Kim et al. (2022) [44]15780/202970% immediate dryness64.4% at 9 mo8.3% BCR at 9 moExtraperitoneal SP approach.
(Transperineal)Lenfant et al. (2021) [47]26~70/3065.475% dryness at 3 moNot stated~4% BCRSingle-port perineal route.
Yu et al. (2023) [46]50~85/151048–80% dryness by 3 mo, 96–100% at 6–12 moNot stated1 BCR at 12 monthAnother single-surgeon series.
Abbreviations: PSM, positive surgical margin; UC, urinary continence; BCR, biochemical recurrence; EP, extraperitoneal; TP, transperitoneal.
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.

Share and Cite

MDPI and ACS Style

Jo, S.B.; Kim, J.W. Recent Advances in Radical Prostatectomy: A Narrative Review of Surgical Innovations and Outcomes. Cancers 2025, 17, 902. https://doi.org/10.3390/cancers17050902

AMA Style

Jo SB, Kim JW. Recent Advances in Radical Prostatectomy: A Narrative Review of Surgical Innovations and Outcomes. Cancers. 2025; 17(5):902. https://doi.org/10.3390/cancers17050902

Chicago/Turabian Style

Jo, Seon Beom, and Jong Wook Kim. 2025. "Recent Advances in Radical Prostatectomy: A Narrative Review of Surgical Innovations and Outcomes" Cancers 17, no. 5: 902. https://doi.org/10.3390/cancers17050902

APA Style

Jo, S. B., & Kim, J. W. (2025). Recent Advances in Radical Prostatectomy: A Narrative Review of Surgical Innovations and Outcomes. Cancers, 17(5), 902. https://doi.org/10.3390/cancers17050902

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop