Recent Advances in Radical Prostatectomy: A Narrative Review of Surgical Innovations and Outcomes
Simple Summary
Abstract
1. Introduction
2. The History and Evolution of Radical Prostatectomy
3. A Spectrum of Surgical Approaches in Robot-Assisted Radical Prostatectomy: Standard, Hood, Lateral, and Retzius-Sparing Techniques
3.1. Standard (Anterior) RARP and Its Refinements
3.2. Hood Techniques
3.3. Lateral Approach
3.4. Retzius-Sparing (Posterior) Access
4. Optimizing Functional Recovery: Bladder Neck, Urethral, and ARVUS Techniques
4.1. Bladder Neck Preservation (BNP)
4.2. Urethral Preservation
4.3. The ARVUS Technique
5. Single-Port RARP and Novel Access Routes
5.1. Rationale and Initial Adoption
5.2. Extraperitoneal and Transperitoneal Approach
5.3. Transperineal Single-Port
5.4. Transvesical Single-Port
6. Clinical Outcomes Across Multiple Approaches: A Comparative Table
7. Discussion
8. Conclusions
Author Contributions
Funding
Conflicts of Interest
Abbreviations
DVC | Dorsal venous complex |
LRP | Laparoscopic radical prostatectomy |
PSM | Positive surgical margin |
RARP | Robot-assisted radical prostatectomy |
RP | Radical prostatectomy |
SP | Single-port |
UC | Urinary continence |
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Approach | Study (Year) | N | Stage pT2/pT3 (%) | PSM (%) | Early Continence | Potency (≥6 mo) | BCR or PSA | Notes |
---|---|---|---|---|---|---|---|---|
Standard (Anterior) | Ficarra et al. (2009) [5] | 4000+ | Mixed | 10–20 (pT2) | ~40–60% at 1–3 mo | ~50–70% vary. | ~5–10% at 1–2 y | Systematic review comparing laparoscopic/robotic vs. open. |
Menon et al. (2009) [53] | 1100 | ~80/20 | 15–20 | 45–55% at 1 mo, ~90% at 1 y | ~70–75% at 12 mo | ~5–8% | “Veil of Aphrodite” pioneer. | |
Patel et al. (2011) [54] | 4000 | ~76.2/22.9 | 10.8% (overall) | 67.7% at 6 wk, 85.4% at 3 mo | 91.5% at 1 y | 9.5% at 12 mo | Multi-institutional study; reports pentafecta outcomes. | |
Hood-Sparing | Wagaskar et al. (2021) [10] | 300 | ~75/25 | 6 | 80% at 1 mo, 91% at 3 mo | ~70–80% (1 y) | ~5% short | Hood technique preserves periurethral structures. |
Shimmura et al. (2023) [11] | 42 | ~70/30 | 16 | 69% at 1 mo, 91% at 3 mo | Not precisely stated | Not reported | Umbilical lig. + Hood; small single-center. | |
Retzius-Sparing (Posterior) | Galfano et al. (2013) [23] | 200 | ~80/20 | 15–20 | 70–80% immediate to 1 mo | ~65–75% at 1 y | ~5–6% | Pioneer posterior approach. |
Dalela et al. (2017) [33] | 100 | 85/15 | 18 | 71% vs. 47% (std) at 1 mo | ~70% at 1 y | 5–6% ~1 y | Pragmatic RCT favoring RS for early continence. | |
Egan et al. (2021) [35] | 70 | 80/20 | 34.3 | 95% dryness at 1 y | 65.7% at 1 y | ~4–5% | Possibly advanced disease. | |
Lateral | Rodríguez Socarrás et al. (2023) [29] | 513 | ~70/30 | 33–38 | ~85–86% immediate dryness | Not reported | Not reported | Large cohort; good short-term UC; steep learning curve. |
Giulioni et al. (2024) [30] | 70 | ~60/40 | 15 | 81% dryness at 6 wk, 94% at 1 y | 84% at 1 y | Not reported | Single-surgeon experience; stable PSM . | |
Single-Port (SP) | ||||||||
(Transvesical) | Deng et al. (2021) [50] | 60 | 90/10 | 15 | 90% dryness at removal | 60–70% at 3–6 mo | ~5% BCR at 12 month | Transvesical retzius-sparing advantage. |
Zhou et al. (2020) [51] | 35 | 80/20 | 11.4 | 91% immediate in smaller series | ~65–70% 3–6 mo | No BCR short | No recurrences short term. | |
Chung et al. (2024) [52] | 4 | 50/50 | 50 | 100% continence at removal, safety pad at 1 mo | Not measured fully | 1 persistent PSA | Very small case series; 2 advanced diseases. | |
Ramos-Carpinteyro (2023) [48] | 100 | ~80/20 | ~20? | 80–90% immediate dryness | ~65–70% (≥6 mo) | Not fully stated | First 100 transvesical SP cases from a single center. | |
(Extraperitoneal) | Abou Zeinab et al. (2023) [55] | 238 | ~75/25 | ~29 (EP) | 70% dryness at 1 mo (extraperitoneal) | ~60–65% potency | ~9% BCR short | Large multi-institution EP vs. TP matched. |
Kim et al. (2022) [44] | 157 | 80/20 | 29 | 70% immediate dryness | 64.4% at 9 mo | 8.3% BCR at 9 mo | Extraperitoneal SP approach. | |
(Transperineal) | Lenfant et al. (2021) [47] | 26 | ~70/30 | 65.4 | 75% dryness at 3 mo | Not stated | ~4% BCR | Single-port perineal route. |
Yu et al. (2023) [46] | 50 | ~85/15 | 10 | 48–80% dryness by 3 mo, 96–100% at 6–12 mo | Not stated | 1 BCR at 12 month | Another single-surgeon series. |
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Jo, S.B.; Kim, J.W. Recent Advances in Radical Prostatectomy: A Narrative Review of Surgical Innovations and Outcomes. Cancers 2025, 17, 902. https://doi.org/10.3390/cancers17050902
Jo SB, Kim JW. Recent Advances in Radical Prostatectomy: A Narrative Review of Surgical Innovations and Outcomes. Cancers. 2025; 17(5):902. https://doi.org/10.3390/cancers17050902
Chicago/Turabian StyleJo, Seon Beom, and Jong Wook Kim. 2025. "Recent Advances in Radical Prostatectomy: A Narrative Review of Surgical Innovations and Outcomes" Cancers 17, no. 5: 902. https://doi.org/10.3390/cancers17050902
APA StyleJo, S. B., & Kim, J. W. (2025). Recent Advances in Radical Prostatectomy: A Narrative Review of Surgical Innovations and Outcomes. Cancers, 17(5), 902. https://doi.org/10.3390/cancers17050902