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Journal of Personalized Medicine, Volume 15, Issue 7

July 2025 - 64 articles

Cover Story: Genetic variants in cytochrome P450 (CYP) enzymes, particularly CYP2C9 and CYP2C19, have significant impacts on drug metabolism, influencing therapeutic efficacy and adverse drug reactions. While allele frequency studies commonly group diverse populations under broad categories such as “Asian” or “European”, such grouping masks critical intra-regional and ethnic variation. The lumping of diverse regional and cultural groups into a major racial categorization can perpetuate gaps in pharmacogenetic knowledge and widen existing health disparities. Herein, we present a case study that disaggregates major allele frequencies of CYP2C9 and CYP2C19 into multiple Asian and European cohorts. By highlighting population-specific genetic diversity, our work aims to refine pharmacogenomic dosing guidelines and support truly individualized medicine strategies. View this paper
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Articles (64)

  • Article
  • Open Access
877 Views
10 Pages

20 July 2025

Background: Inhaled corticosteroids (ICSs) are a cornerstone in asthma management, particularly during exacerbations, when high doses are often prescribed. However, patient concerns about potential side effects such as increased appetite, weight gain...

  • Article
  • Open Access
703 Views
18 Pages

19 July 2025

Background/Objectives: Electronic medical record systems play a crucial role in the operation of modern healthcare institutions, enabling the foundational data necessary for advancements in personalized medicine. Despite their importance, the softwar...

  • Article
  • Open Access
1,433 Views
9 Pages

Total Thyroidectomy vs. Lobectomy in Papillary Thyroid Microcarcinoma: A Contested Gold Standard

  • Enrico Battistella,
  • Luca Pomba,
  • Riccardo Toniato,
  • Andrea Piotto and
  • Antonio Toniato

18 July 2025

Background: Papillary thyroid microcarcinoma (PTMC), a subtype of papillary thyroid carcinoma ≤ 1 cm in diameter, has shown a marked increase in incidence in recent decades, largely due to the widespread use of neck ultrasonography and fine needle...

  • Article
  • Open Access
1 Citations
573 Views
10 Pages

Children and Adolescents with Mucopolysaccharidosis and Osteogenesis Imperfecta: The Dentistry on the Multiprofessional Team

  • Mariana Laís Silva Celestino,
  • Natália Cristina Ruy Carneiro,
  • Heloisa Vieira Prado,
  • Glória Maria Pimenta Cabral,
  • Mauro Henrique Nogueira Guimarães Abreu and
  • Ana Cristina Borges-Oliveira

18 July 2025

Background/Objectives: To identify factors associated with the referral by a multiprofessional team to dental services for children and adolescents with rare genetic diseases. Methods: A cross-sectional study was developed with 87 children/adolescent...

  • Perspective
  • Open Access
1 Citations
1,524 Views
10 Pages

18 July 2025

Pregnant individuals who receive a fetal anomaly diagnosis experience significantly elevated rates of depression, anxiety, and traumatic stress—up to four to six times higher than those for individuals with low-risk pregnancies. In low-risk pre...

  • Article
  • Open Access
818 Views
11 Pages

17 July 2025

Background: Male breast cancer (MBC) is extremely rare, representing less than 1% of breast cancer (BC). Owing to the rarity, there is a substantial knowledge gap regarding the survival trends of MBC compared with female breast cancer (FBC). Methods:...

  • Article
  • Open Access
1 Citations
2,372 Views
23 Pages

Clinical Outcomes of 3D-Printed Titanium Patient-Specific Implants in Lumbar Interbody Fusion: A Prospective Clinical Trial with a Systematic Review of Conventional Techniques

  • Kevin A. Seex,
  • Ralph J. Mobbs,
  • Marc Coughlan,
  • Matthew Pelletier,
  • William R. Walsh,
  • Jackson C. Hill and
  • William C. H. Parr

16 July 2025

Background: Lumbar Interbody Fusion (LIF) is a surgical procedure aimed at addressing a range of pathological conditions affecting the structure and function of the spine. Patient-Specific Interbody Cages (PSICs) are an emerging technology that are u...

  • Case Report
  • Open Access
1 Citations
1,086 Views
12 Pages

Awake Craniotomy for the Excision of a Pediatric Cerebral Arteriovenous Malformation for Language Preservation: A Case Description

  • Melody Long,
  • C. Thiaghu,
  • Tien Meng Cheong,
  • Ramez W. Kirollos,
  • Julian Han,
  • Lee Ping Ng and
  • Sharon Y. Y. Low

15 July 2025

Background: Awake craniotomy (AC) surgeries are less common in the pediatric population in comparison to their adult counterparts. Nonetheless, they can be considered for selected cases whereby speech preservation is paramount during maximal safe res...

  • Review
  • Open Access
867 Views
16 Pages

The Role of Intravascular Imaging in Coronary Chronic Total Occlusion PCI: Enhancing Procedural Success Through Real-Time Visualization

  • Hussein Sliman,
  • Rim Kasem Ali Sliman,
  • Paul Knaapen,
  • Alex Nap,
  • Grzegorz Sobieszek and
  • Maksymilian P. Opolski

15 July 2025

Coronary chronic total occlusions (CTOs) are diagnosed in a significant portion of patients undergoing coronary angiography and represent one of the most complex scenarios in contemporary percutaneous coronary interventions (PCI). This review systema...

  • Systematic Review
  • Open Access
2,185 Views
39 Pages

Early vs. Late Oral Feeding After Surgery for Patients with Esophageal Malignancy: A Systematic Review and Meta-Analysis of Postoperative Clinical Outcomes and Quality of Life

  • Raghad Fahad Alrasheed,
  • Abdullah Salem Laradhi,
  • Reema Saeed Alqahtani,
  • Sarah Mazin Alharthi,
  • Waleed Amin Alamoudi,
  • Zainudheen Faroog,
  • Sham Yasser Almohammad,
  • Jana Ayman Basmaih,
  • Nasser Turki Alotaibi and
  • Ahmed Elaraby
  • + 2 authors

15 July 2025

Introduction: Esophagectomy for esophageal cancer traditionally involves delayed postoperative oral feeding due to concerns about complications like anastomotic leakage. Enhanced Recovery After Surgery (ERAS) protocols favor early oral feeding (EOF),...

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J. Pers. Med. - ISSN 2075-4426Creative Common CC BY license