Major Vault Protein/Lung Resistance-Related Protein: A Novel Biomarker for Inflammation and Acute Infections
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Laboratory Measurements
2.3. Statistical Analysis
3. Results
3.1. General Features of the Examined Cohort
3.2. Patients with Inflammation Exhibit Higher Levels of MVP as Compared to Healthy Individuals
3.3. Patients with Infection Exhibit Higher Levels of MVP as Compared to Patients with Inflammation of Non-Infectious Etiology
3.4. High MVP Levels Are Not Exclusively Associated with Cancer
3.5. Correlations between MVP and Other Markers/Proteins of Inflammation
3.6. Diagnostic Accuracy of MVP, CRP, and WBCs for Inflammation
3.7. MVP Levels during Inflammation
4. Discussion
5. Conclusions
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
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Characteristic | Value |
---|---|
Number of samples | 111 (100%) |
Healthy individuals | 26 (23.4%) |
Patients with inflammation | 85 (76.6%) |
-Infection | 36 (32.4%) |
-Cancer | 25 (22.5%) |
-Infection and cancer | 3 (2.7%) |
-Other | 27 (24.3%) |
Age (years) ± SD | 63 ± 20 |
Gender | |
-Female | 33 (29.7%) |
-Male | 78 (70.3%) |
CRP-positive | 64.50% |
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Routsias, J.G.; Marinou, D.; Mavrouli, M.; Tsakris, A.; Pitiriga, V.C. Major Vault Protein/Lung Resistance-Related Protein: A Novel Biomarker for Inflammation and Acute Infections. Microorganisms 2024, 12, 1762. https://doi.org/10.3390/microorganisms12091762
Routsias JG, Marinou D, Mavrouli M, Tsakris A, Pitiriga VC. Major Vault Protein/Lung Resistance-Related Protein: A Novel Biomarker for Inflammation and Acute Infections. Microorganisms. 2024; 12(9):1762. https://doi.org/10.3390/microorganisms12091762
Chicago/Turabian StyleRoutsias, John G., Dionysia Marinou, Maria Mavrouli, Athanasios Tsakris, and Vassiliki C. Pitiriga. 2024. "Major Vault Protein/Lung Resistance-Related Protein: A Novel Biomarker for Inflammation and Acute Infections" Microorganisms 12, no. 9: 1762. https://doi.org/10.3390/microorganisms12091762