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Microorganisms, Volume 7, Issue 2

2019 February - 35 articles

Cover Story: Candida glabrata is an opportunistic human fungal pathogen that is capable of causing both superficial mucosal and life-threatening bloodstream infections in immunocompromised individuals. In this article, we provide an overview of its pathogenesis traits, nutrient acquisition pathways, and host interaction mechanisms. The ability of C. glabrata to adhere to host cells, form biofilms on biotic and abiotic surfaces, replicate in macrophages, and survive diverse stresses including antifungal drugs contributes to its success as a nosocomial pathogen. View this paper.
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Articles (35)

  • Correction
  • Open Access
3 Citations
2,870 Views
1 Page

Correction: Hokynar, K. et al. Chlamydia-Like Organisms (CLOs) in Finnish Ixodes ricinus Ticks and Human Skin. Microorganisms 2016, 4, 28

  • Kati Hokynar,
  • Jani J. Sormunen,
  • Eero J. Vesterinen,
  • Esa K. Partio,
  • Thomas Lilley,
  • Veera Timonen,
  • Jaana Panelius,
  • Annamari Ranki and
  • Mirja Puolakkainen

The authors wish to make the following modification to this paper [...]

  • Article
  • Open Access
40 Citations
6,752 Views
13 Pages

Refined versus Extra Virgin Olive Oil High-Fat Diet Impact on Intestinal Microbiota of Mice and Its Relation to Different Physiological Variables

  • Nieves Martínez,
  • Isabel Prieto,
  • Marina Hidalgo,
  • Ana Belén Segarra,
  • Ana M. Martínez-Rodríguez,
  • Antonio Cobo,
  • Manuel Ramírez,
  • Antonio Gálvez and
  • Magdalena Martínez-Cañamero

Extra virgin olive oil (EVOO) has been reported to have a distinct influence on gut microbiota in comparison to other fats, with its physiological benefits widely studied. However, a large proportion of the population consumes olive oil after a depur...

  • Review
  • Open Access
11 Citations
9,142 Views
11 Pages

Can Gut Microbiota and Lifestyle Help Us in the Handling of Anorexia Nervosa Patients?

  • Vanessa Mendez-Figueroa,
  • Jose Miguel Biscaia,
  • Rosa B. Mohedano,
  • Ascension Blanco-Fernandez,
  • Maria Bailen,
  • Carlo Bressa,
  • Mar Larrosa and
  • Rocio Gonzalez-Soltero

Gut microbiota is composed of different microorganisms that play an important role in the host. New research shows that bidirectional communications happen between intestinal microbiota and the brain, which is known as the gut–brain axis. This...

  • Article
  • Open Access
36 Citations
7,717 Views
23 Pages

What an Escherichia coli Mutant Can Teach Us About the Antibacterial Effect of Chlorophyllin

  • Marcus Krüger,
  • Peter Richter,
  • Sebastian M. Strauch,
  • Adeel Nasir,
  • Andreas Burkovski,
  • Camila A. Antunes,
  • Tina Meißgeier,
  • Eberhard Schlücker,
  • Stefan Schwab and
  • Michael Lebert

Due to the increasing development of antibiotic resistances in recent years, scientists search intensely for new methods to control bacteria. Photodynamic treatment with porphyrins such as chlorophyll derivatives is one of the most promising methods...

  • Article
  • Open Access
42 Citations
5,658 Views
15 Pages

Crop monocropping usually results in an enrichment of soil-borne pathogens in soil. Crop rotation is an environmentally friendly method for controlling soil-borne diseases. Plant rhizosphere microorganisms, especially plant-beneficial microorganisms,...

  • Article
  • Open Access
7 Citations
4,958 Views
18 Pages

In Silico Analysis of Genetic VapC Profiles from the Toxin-Antitoxin Type II VapBC Modules among Pathogenic, Intermediate, and Non-Pathogenic Leptospira

  • Alexandre P. Y. Lopes,
  • Bruna O. P. Azevedo,
  • Rebeca C. Emídio,
  • Deborah K. Damiano,
  • Ana L. T. O. Nascimento and
  • Giovana C. Barazzone

Pathogenic Leptospira spp. is the etiological agent of leptospirosis. The high diversity among Leptospira species provides an array to look for important mediators involved in pathogenesis. Toxin-antitoxin (TA) systems represent an important survival...

  • Article
  • Open Access
11 Citations
4,292 Views
12 Pages

Merkel Cell Polyomavirus Is Associated with Anal Infections in Men Who Have Sex with Men

  • Nunzia Zanotta,
  • Serena Delbue,
  • Lucia Signorini,
  • Sonia Villani,
  • Sarah D’Alessandro,
  • Giuseppina Campisciano,
  • Claudia Colli,
  • Francesco De Seta,
  • Pasquale Ferrante and
  • Manola Comar

Background: Viral infections of the anal/rectal tract of men who have sex with men (MSM) have been poorly studied. Methods: In total, 158 swab samples (81 anal/rectal, 65 throat/oral and 12 urethral) were collected from 126 MSM. DNA was isolated and...

  • Review
  • Open Access
86 Citations
9,122 Views
17 Pages

Plasmid-Mediated Colistin Resistance in Salmonella enterica: A Review

  • Tiago Lima,
  • Sara Domingues and
  • Gabriela Jorge Da Silva

Colistin is widely used in food-animal production. Salmonella enterica is a zoonotic pathogen, which can pass from animal to human microbiota through the consumption of contaminated food, and cause disease, often severe, especially in young children,...

  • Review
  • Open Access
217 Citations
13,601 Views
27 Pages

Subsurface Microbial Hydrogen Cycling: Natural Occurrence and Implications for Industry

  • Simon P. Gregory,
  • Megan J. Barnett,
  • Lorraine P. Field and
  • Antoni E. Milodowski

Hydrogen is a key energy source for subsurface microbial processes, particularly in subsurface environments with limited alternative electron donors, and environments that are not well connected to the surface. In addition to consumption of hydrogen,...

  • Article
  • Open Access
5 Citations
5,228 Views
11 Pages

Effects of Bifidobacterium bifidum in Mice Infected with Citrobacter rodentium

  • Bijun Wen,
  • Amel Taibi,
  • Christopher R. Villa,
  • Shin-Hann Lee,
  • Sofia Sagaidak and
  • Elena M. Comelli

In vitro and in vivo studies suggest that selected Bifidobacterium bifidum strains sustain intestinal homeostasis. This study aimed to examine whether the administration of B. bifidum MIMBb75 (BB75) attenuates Citrobacter rodentium infection, a murin...

  • Article
  • Open Access
6 Citations
4,627 Views
12 Pages

ATP- and Polyphosphate-Dependent Glucokinases from Aerobic Methanotrophs

  • Alexander S. Reshetnikov,
  • Natalia P. Solntseva,
  • Olga N. Rozova,
  • Ildar I. Mustakhimov,
  • Yuri A. Trotsenko and
  • Valentina N. Khmelenina

The genes encoding adenosine triphosphate (ATP)- and polyphosphate (polyP)-dependent glucokinases (Glk) were identified in the aerobic obligate methanotroph Methylomonas sp. 12. The recombinant proteins were obtained by the heterologous expression of...

  • Article
  • Open Access
12 Citations
6,191 Views
17 Pages

Phylogenomic Analyses of Bradyrhizobium Reveal Uneven Distribution of the Lateral and Subpolar Flagellar Systems, Which Extends to Rhizobiales

  • Daniel Garrido-Sanz,
  • Miguel Redondo-Nieto,
  • Elías Mongiardini,
  • Esther Blanco-Romero,
  • David Durán,
  • Juan I. Quelas,
  • Marta Martin,
  • Rafael Rivilla,
  • Aníbal R. Lodeiro and
  • M. Julia Althabegoiti

Dual flagellar systems have been described in several bacterial genera, but the extent of their prevalence has not been fully explored. Bradyrhizobium diazoefficiens USDA 110T possesses two flagellar systems, the subpolar and the lateral flagella. Th...

  • Review
  • Open Access
25 Citations
8,795 Views
13 Pages

PES Pathogens in Severe Community-Acquired Pneumonia

  • Catia Cillóniz,
  • Cristina Dominedò,
  • Antonello Nicolini and
  • Antoni Torres

Worldwide, there is growing concern about the burden of pneumonia. Severe community-acquired pneumonia (CAP) is frequently complicated by pulmonary and extra-pulmonary complications, including sepsis, septic shock, acute respiratory distress syndrome...

  • Article
  • Open Access
17 Citations
4,616 Views
15 Pages

Root-Associated Endophytic Bacterial Community Composition of Pennisetum sinese from Four Representative Provinces in China

  • Zhen-Shan Deng,
  • Bao-Cheng Zhang,
  • Xiang-Ying Qi,
  • Zhi-Hong Sun,
  • Xiao-Long He,
  • Yu-Zhen Liu,
  • Jing Li,
  • Kai-Kai Chen and
  • Zhan-Xi Lin

Pennisetum sinese, a source of bio-energy with high biomass production, is a species that contains high crude protein and will be useful for solving the shortage of forage grass after the implementation of “Green for Grain” project in the...

  • Review
  • Open Access
44 Citations
5,871 Views
12 Pages

Extracellular Vesicles in Epstein-Barr Virus’ Life Cycle and Pathogenesis

  • Mengmeng Zhao,
  • Asuka Nanbo,
  • Lichun Sun and
  • Zhen Lin

Extracellular vesicles (EVs), including exosomes and microvesicles, are evolutionarily conserved phospholidpid membrane-bound entities secreted from most eukaryotic cell types. They carry bioactive cargos such as protein and nucleic acids derived fro...

  • Article
  • Open Access
22 Citations
4,670 Views
15 Pages

Dynamics of Hydrology and Anaerobic Hydrocarbon Degrader Communities in A Tar-Oil Contaminated Aquifer

  • Giovanni Pilloni,
  • Anne Bayer,
  • Bettina Ruth-Anneser,
  • Lucas Fillinger,
  • Marion Engel,
  • Christian Griebler and
  • Tillmann Lueders

Aquifers are typically perceived as rather stable habitats, characterized by low biogeochemical and microbial community dynamics. Upon contamination, aquifers shift to a perturbed ecological status, in which specialized populations of contaminant deg...

  • Article
  • Open Access
47 Citations
7,188 Views
17 Pages

The Foodborne Strain Lactobacillus fermentum MBC2 Triggers pept-1-Dependent Pro-Longevity Effects in Caenorhabditis elegans

  • Emily Schifano,
  • Paola Zinno,
  • Barbara Guantario,
  • Marianna Roselli,
  • Sante Marcoccia,
  • Chiara Devirgiliis and
  • Daniela Uccelletti

Lactic acid bacteria (LAB) are involved in several food fermentations and many of them provide strain-specific health benefits. Herein, the probiotic potential of the foodborne strain Lactobacillus fermentum MBC2 was investigated through in vitro and...

  • Review
  • Open Access
14 Citations
6,616 Views
16 Pages

The recent and massive revival of green strategies to control plant diseases, mainly as a consequence of the Integrated Pest Management (IPM) rules issued in 2009 by the European Community and the increased consumer awareness of organic products, pos...

  • Article
  • Open Access
10 Citations
5,398 Views
13 Pages

Environmental Aspects of the Use of Hedera helix Extract in Bioremediation Process

  • Agata Zdarta,
  • Wojciech Smułek,
  • Amanda Pacholak and
  • Ewa Kaczorek

This paper analyzes the impact of saponins from English ivy leaves on the properties of environmental bacterial strains and hydrocarbon degradation ability. For this purpose, two bacterial strains, Raoultella ornitinolytica M03 and Acinetobacter calc...

  • Article
  • Open Access
8 Citations
5,994 Views
18 Pages

Optimization of In Vitro Mycobacterium avium and Mycobacterium intracellulare Growth Assays for Therapeutic Development

  • Lauren Auster,
  • Morgan Sutton,
  • Mary Chandler Gwin,
  • Christopher Nitkin and
  • Tracey L. Bonfield

Infection with nontuberculous mycobacteria (NTM) is a complication of lung disease in immunocompromised patients, including those with human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS), chronic obstructive pulmonary dise...

  • Review
  • Open Access
219 Citations
33,282 Views
21 Pages

This article reviews the current evidence associating gut microbiota with factors that impact host circadian-metabolic axis, such as light/dark cycles, sleep/wake cycles, diet, and eating patterns. We examine how gut bacteria possess their own daily...

  • Review
  • Open Access
89 Citations
12,936 Views
22 Pages

Candida glabrata: A Lot More Than Meets the Eye

  • Kundan Kumar,
  • Fizza Askari,
  • Mahima Sagar Sahu and
  • Rupinder Kaur

Candida glabrata is an opportunistic human fungal pathogen that causes superficial mucosal and life-threatening bloodstream infections in individuals with a compromised immune system. Evolutionarily, it is closer to the non-pathogenic yeast Saccharom...

  • Review
  • Open Access
81 Citations
12,604 Views
23 Pages

Recombinant protein production represents a multibillion-dollar market. Therefore, it constitutes an important research field both in academia and industry. The use of yeast as a cell factory presents several advantages such as ease of genetic manipu...

  • Article
  • Open Access
58 Citations
7,665 Views
18 Pages

The Form of N Supply Determines Plant Growth Promotion by P-Solubilizing Microorganisms in Maize

  • Isaac Kwadwo Mpanga,
  • Peteh Mehdi Nkebiwe,
  • Mira Kuhlmann,
  • Vincenza Cozzolino,
  • Alessandro Piccolo,
  • Jörg Geistlinger,
  • Nils Berger,
  • Uwe Ludewig and
  • Günter Neumann

Phosphate-(P)-solubilizing microorganisms (PSM) are important drivers of P cycling in natural and agro-ecosystems. Their use as plant inoculants to improve P acquisition of crops has been investigated for decades. However, limited reproducibility of...

  • Article
  • Open Access
16 Citations
5,397 Views
23 Pages

Despite the importance of endophytic fungi for plant health, it remains unclear how these fungi are influenced by grassland management practices. Here, we investigated the effect of fertilizer application and mowing frequency on fungal endophyte comm...

  • Article
  • Open Access
27 Citations
5,926 Views
16 Pages

A Piscibacillus sp. Isolated from A Soda Lake Exhibits Anticancer Activity Against Breast Cancer MDA-MB-231 Cells

  • Deepesh Kumar Neelam,
  • Akhil Agrawal,
  • Anuj Kumar Tomer,
  • Shreetama Bandyopadhayaya,
  • Ankit Sharma,
  • Medicharla V. Jagannadham,
  • Chandi C. Mandal and
  • Pawan K. Dadheech

Microorganisms thrive in extreme environments and are known for synthesizing valuable metabolites. Salt-loving microorganisms can flourish in saline environments which inhibit the growth of other microbial life, and they possess the potential to prod...

  • Article
  • Open Access
65 Citations
5,030 Views
11 Pages

Inhibitory Effect of 7-Demethoxytylophorine on Penicillium italicum and its Possible Mechanism

  • Chuying Chen,
  • Wenwen Qi,
  • Xuan Peng,
  • Jinyin Chen and
  • Chunpeng Wan

7-demethoxytylophorine (DEM) is a phenanthroindolizidine alkaloid, which is reported to be effective in inhibiting leucocytes and regulation of human immunity. However, few studies reported the inhibitory effect of DEM against plant-pathogenic fungi,...

  • Article
  • Open Access
41 Citations
9,509 Views
32 Pages

The Purple Sea Urchin Strongylocentrotus purpuratus Demonstrates a Compartmentalization of Gut Bacterial Microbiota, Predictive Functional Attributes, and Taxonomic Co-Occurrence

  • Joseph A. Hakim,
  • Julie B. Schram,
  • Aaron W. E. Galloway,
  • Casey D. Morrow,
  • Michael R. Crowley,
  • Stephen A. Watts and
  • Asim K. Bej

The sea urchin Strongylocentrotus purpuratus (order Camarodonta, family Strongylocentrotidae) can be found dominating low intertidal pool biomass on the southern coast of Oregon, USA. In this case study, three adult sea urchins were collected from th...

  • Article
  • Open Access
24 Citations
4,992 Views
13 Pages

Cave Drip Water-Related Samples as a Natural Environment for Aromatic Hydrocarbon-Degrading Bacteria

  • Eric L. S. Marques,
  • Gislaine S. Silva,
  • João C. T. Dias,
  • Eduardo Gross,
  • Moara S. Costa and
  • Rachel P. Rezende

Restricted contact with the external environment has allowed the development of microbial communities adapted to the oligotrophy of caves. However, nutrients can be transported to caves by drip water and affect the microbial communities inside the ca...

  • Article
  • Open Access
42 Citations
6,564 Views
7 Pages

Competence for Natural Transformation Is Common among Clinical Strains of Resistant Acinetobacter spp.

  • Sara Domingues,
  • Natasha Rosário,
  • Ângela Cândido,
  • Daniela Neto,
  • Kaare M. Nielsen and
  • Gabriela J. Da Silva

Horizontal gene transfer events provide the basis for extensive dissemination of antimicrobial resistance traits between bacterial populations. Conjugation is considered to be the most frequent mechanism behind new resistance acquisitions in clinical...

  • Article
  • Open Access
16 Citations
6,536 Views
16 Pages

Valley Fever on the Rise—Searching for Microbial Antagonists to the Fungal Pathogen Coccidioides immitis

  • Antje Lauer,
  • Joe Darryl Baal,
  • Susan D. Mendes,
  • Kayla Nicole Casimiro,
  • Alyce Kayes Passaglia,
  • Alex Humberto Valenzuela and
  • Gerry Guibert

The incidence of coccidioidomycosis, also known as Valley Fever, is increasing in the Southwestern United States and Mexico. Despite considerable efforts, a vaccine to protect humans from this disease is not forthcoming. The aim of this project was t...

  • Article
  • Open Access
7 Citations
3,944 Views
17 Pages

High-Throughput Rapid and Inexpensive Assay for Quantitative Determination of Low Cell-Density Yeast Cultures

  • Debora Casagrande Pierantoni,
  • Laura Corte,
  • Luca Roscini and
  • Gianluigi Cardinali

A procedure for microbial cell density determination with a high-throughput densitometric assay was developed to allow a precise quantification of both free and sessile cells, such as those of a biofilm, with a large range from low to high cell densi...

  • Article
  • Open Access
30 Citations
4,300 Views
14 Pages

The antimicrobial activity of the marine bisindole alkaloid 2,2-bis(6-bromo-3-indolyl) ethylamine (1) and related synthetic analogues (compounds 28) against target microorganisms was investigated by Minimum Inhibitory Concentration (MIC) deter...

  • Article
  • Open Access
11 Citations
5,121 Views
10 Pages

Purple Sulfur Bacteria Dominate Microbial Community in Brazilian Limestone Cave

  • Eric L. S. Marques,
  • João C. T. Dias,
  • Eduardo Gross,
  • Adriana B. de Cerqueira e Silva,
  • Suzana R. de Moura and
  • Rachel P. Rezende

The mineralogical composition of caves makes the environment ideal for inhabitation by microbes. However, the bacterial diversity in the cave ecosystem remains largely unexplored. In this paper, we described the bacterial community in an oxic chamber...

  • Review
  • Open Access
22 Citations
6,810 Views
10 Pages

Dinoflagellates have some of the largest genome sizes, but lack architectural nucleosomes. Their liquid crystalline chromosomes (LCCs) are the only non-architectural protein-mediated chromosome packaging systems, having high degrees of DNA superhelic...

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Microorganisms - ISSN 2076-2607