Cutaneous Fibrous Histiocytomas, Ossifying-Variant with Osteoclast-like Giant Cells and Granular Cell-Variant: A Series of Two Unusual Cases with Emphasis on the Differential Diagnosis

Farina, Jessica; Broggi, Giuseppe; Caltabiano, Rosario

doi:10.3390/app12062977

Open AccessCase Report

Cutaneous Fibrous Histiocytomas, Ossifying-Variant with Osteoclast-like Giant Cells and Granular Cell-Variant: A Series of Two Unusual Cases with Emphasis on the Differential Diagnosis

by

Jessica Farina

,

Giuseppe Broggi

^*

and

Rosario Caltabiano

Department of Medical, Surgical Sciences and Advanced Technologies “G.F. Ingrassia”, Anatomic Pathology, University of Catania, 95123 Catania, Italy

^*

Author to whom correspondence should be addressed.

Appl. Sci. 2022, 12(6), 2977; https://doi.org/10.3390/app12062977

Submission received: 3 February 2022 / Revised: 11 March 2022 / Accepted: 13 March 2022 / Published: 15 March 2022

(This article belongs to the Special Issue Current Topics in the Diagnostic Approach to Skin Diseases)

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Abstract

The ossifying variant and the granular cell variant are rare subtypes of cutaneous fibrous histiocytoma (CFH), characterized by islands of mature metaplastic bone tissue rimmed by multinucleated osteoclast-like giant cells and by large-sized cells with granular cytoplasm and mildly hyperchromatic nuclei with inconspicuous nucleoli, respectively. We herein present two cases of these unusual CFH variants in a 37-year-old woman and in a 38-year-old man, respectively. The main differential diagnoses, including both benign and malignant lesions, are also discussed.

Keywords: cutaneous fibrous histiocytoma; dermatofibroma; differential diagnosis; granular cell; ossifying variant

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MDPI and ACS Style

Farina, J.; Broggi, G.; Caltabiano, R. Cutaneous Fibrous Histiocytomas, Ossifying-Variant with Osteoclast-like Giant Cells and Granular Cell-Variant: A Series of Two Unusual Cases with Emphasis on the Differential Diagnosis. Appl. Sci. 2022, 12, 2977. https://doi.org/10.3390/app12062977

AMA Style

Farina J, Broggi G, Caltabiano R. Cutaneous Fibrous Histiocytomas, Ossifying-Variant with Osteoclast-like Giant Cells and Granular Cell-Variant: A Series of Two Unusual Cases with Emphasis on the Differential Diagnosis. Applied Sciences. 2022; 12(6):2977. https://doi.org/10.3390/app12062977

Chicago/Turabian Style

Farina, Jessica, Giuseppe Broggi, and Rosario Caltabiano. 2022. "Cutaneous Fibrous Histiocytomas, Ossifying-Variant with Osteoclast-like Giant Cells and Granular Cell-Variant: A Series of Two Unusual Cases with Emphasis on the Differential Diagnosis" Applied Sciences 12, no. 6: 2977. https://doi.org/10.3390/app12062977

APA Style

Farina, J., Broggi, G., & Caltabiano, R. (2022). Cutaneous Fibrous Histiocytomas, Ossifying-Variant with Osteoclast-like Giant Cells and Granular Cell-Variant: A Series of Two Unusual Cases with Emphasis on the Differential Diagnosis. Applied Sciences, 12(6), 2977. https://doi.org/10.3390/app12062977

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Cutaneous Fibrous Histiocytomas, Ossifying-Variant with Osteoclast-like Giant Cells and Granular Cell-Variant: A Series of Two Unusual Cases with Emphasis on the Differential Diagnosis

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