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Article

Chestnut Burrs as Natural Source of Antimicrobial Bioactive Compounds: A Valorization of Agri-Food Waste

by
Alfonso Trezza
1,*,†,
Roberta Barletta
1,†,
Michela Geminiani
1,2,
Luisa Frusciante
1,
Tommaso Olmastroni
1,
Filomena Sannio
3,
Jean-Denis Docquier
3 and
Annalisa Santucci
1,2,4
1
Department of Biotechnology, Chemistry & Pharmacy, University of Siena, Via A. Moro, 53100 Siena, Italy
2
SienabioACTIVE, Università di Siena, Via Aldo Moro, 53100 Siena, Italy
3
Dipartimento di Biotecnologie Mediche, Università degli Studi di Siena, Viale Bracci 16, 53100 Siena, Italy
4
ARTES 4.0, Viale Rinaldo Piaggio, 34, 56025 Pontedera, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Appl. Sci. 2024, 14(15), 6552; https://doi.org/10.3390/app14156552 (registering DOI)
Submission received: 9 July 2024 / Revised: 22 July 2024 / Accepted: 25 July 2024 / Published: 26 July 2024

Abstract

Currently, one-third of global food production, accounting for 1.3 billions tons, goes wasted due to major humanitarian and environmental challenges. In such a scenario, the circular bioeconomy model stands as an innovative solution by promoting sustainable production, utilizing agri-food waste, and converting non-renewable products into valuable resources. Here, the circular bioeconomy concept was applied on a previously obtained chestnut burr extract (agri-food waste) composed of gallic acid, quinic acid, protocatechuic acid, brevifolin carboxylic acid, and ellagic acid to evaluate its antimicrobial activity against four bacterial opportunistic pathogens (Enterococcus faecalis, Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli). Our results evidenced a modest but measurable antibacterial activity against Enterococcus faecalis, with a minimum inhibitory concentration (MIC) of 64 μg/mL. In silico studies allowed for identifying the potential molecular target, supporting the underlying antibacterial activity of the active principle and providing useful molecular findings regarding their interaction. In this study, we show a robust and comprehensive in vitro and in silico pipeline aimed at the identification of novel antibacterial scaffolds taking advantage of agri-food waste.
Keywords: chestnut burrs; circular bioeconomy; antimicrobial activity; Enterococcus faecalis; molecular modeling; docking simulations; molecular dynamics simulations; multiple sequence alignments; MIC chestnut burrs; circular bioeconomy; antimicrobial activity; Enterococcus faecalis; molecular modeling; docking simulations; molecular dynamics simulations; multiple sequence alignments; MIC

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MDPI and ACS Style

Trezza, A.; Barletta, R.; Geminiani, M.; Frusciante, L.; Olmastroni, T.; Sannio, F.; Docquier, J.-D.; Santucci, A. Chestnut Burrs as Natural Source of Antimicrobial Bioactive Compounds: A Valorization of Agri-Food Waste. Appl. Sci. 2024, 14, 6552. https://doi.org/10.3390/app14156552

AMA Style

Trezza A, Barletta R, Geminiani M, Frusciante L, Olmastroni T, Sannio F, Docquier J-D, Santucci A. Chestnut Burrs as Natural Source of Antimicrobial Bioactive Compounds: A Valorization of Agri-Food Waste. Applied Sciences. 2024; 14(15):6552. https://doi.org/10.3390/app14156552

Chicago/Turabian Style

Trezza, Alfonso, Roberta Barletta, Michela Geminiani, Luisa Frusciante, Tommaso Olmastroni, Filomena Sannio, Jean-Denis Docquier, and Annalisa Santucci. 2024. "Chestnut Burrs as Natural Source of Antimicrobial Bioactive Compounds: A Valorization of Agri-Food Waste" Applied Sciences 14, no. 15: 6552. https://doi.org/10.3390/app14156552

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