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Brain Sciences, Volume 8, Issue 1

2018 January - 19 articles

Cover Story: The cover image shows the viability and cell death of cerebellar granule neurons (CGN) (cyan arrow) and astrocytes (red arrow) treated with cerebrospinal fluid (CSF) of Multiple Sclerosis (MS) patients. The CSF of MS patients contain some factors that may have caused selective cell death in CGN. We discuss that those factors may induce cell death by downregulated expression of genes involved in glucose metabolism and ATP production in these CSF-treated neurons. The CSF effect differs according to MS severity; it is higher in relapsing MS with oligoclonal IgG and IgM bands (G+/M+ RMS) and spinal MS, which may be related to their differential restoration capacity of neuronal damage between MS subtypes of patients.View the paper here.
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Articles (19)

  • Review
  • Open Access
8 Citations
7,717 Views
15 Pages

22 January 2018

The treatment of obesity and eating disorders such as binge-eating disorder or anorexia nervosa is challenging. Besides lifestyle changes and pharmacological options, bariatric surgery represents a well-established and effective-albeit invasive-treat...

  • Review
  • Open Access
18 Citations
6,813 Views
5 Pages

DBS in Treatment of Post-Traumatic Stress Disorder

  • Angelo Lavano,
  • Giusy Guzzi,
  • Attilio Della Torre,
  • Serena Marianna Lavano,
  • Raffaele Tiriolo and
  • Giorgio Volpentesta

20 January 2018

Post-traumatic stress disorder (PTSD) is a debilitating psychiatric condition for which pharmacological therapy is not always solvable. Various treatments have been suggested and deep brain stimulation (DBS) is currently under investigation for patie...

  • Review
  • Open Access
53 Citations
7,311 Views
10 Pages

19 January 2018

Advancements in neuroimaging have led to a trend toward direct, image-based targeting under general anesthesia without the use of microelectrode recording (MER) or intraoperative test stimulation, also referred to as “asleep” deep brain stimulation (...

  • Review
  • Open Access
108 Citations
10,197 Views
13 Pages

Glioblastoma under Siege: An Overview of Current Therapeutic Strategies

  • Mayra Paolillo,
  • Cinzia Boselli and
  • Sergio Schinelli

16 January 2018

Glioblastoma is known to be one of the most lethal and untreatable human tumors. Surgery and radiotherapy in combination with classical alkylating agents such as temozolomide offer little hope to escape a poor prognosis. For these reasons, enormous e...

  • Article
  • Open Access
10 Citations
5,723 Views
19 Pages

16 January 2018

The aim of this study is to examine and compare the depression symptoms pattern and social correlates in three groups: foreign-born Chinese Americans, US-born Chinese Americans, and non-Hispanic whites. This study used data from the Collaborative Psy...

  • Case Report
  • Open Access
4 Citations
6,138 Views
7 Pages

Blood Flow and Continuous EEG Changes during Symptomatic Plateau Waves

  • Natalie Kreitzer,
  • Maggie Huynh and
  • Brandon Foreman

12 January 2018

Benign meningiomas uncommonly lead to significant cerebral edema, with only a few cases previously reported in the medical literature. The present study describes the case of a 49-year-old female who had a meningioma resection. She subsequently devel...

  • Case Report
  • Open Access
2 Citations
7,546 Views
8 Pages

The authors present a unique case of recurrent stroke, discovered to be secondary to hemorrhagic conversion of microemboli from a mechanical aortic valve despite anticoagulation with Coumadin. The complexity of this case was magnified by the patient’...

  • Article
  • Open Access
34 Citations
8,545 Views
11 Pages

Neurodegeneration and Sensorimotor Deficits in the Mouse Model of Traumatic Brain Injury

  • Saurav Bhowmick,
  • Veera D‘Mello,
  • Nizmi Ponery and
  • P. M. Abdul Muneer

Traumatic brain injury (TBI) can result in persistent sensorimotor and cognitive deficits, which occur through a cascade of deleterious pathophysiological events over time. In this study, we investigated the hypothesis that neurodegeneration caused b...

  • Review
  • Open Access
33 Citations
8,701 Views
14 Pages

Background: Child neglect is highly prevalent and associated with a series of biological and social consequences. Early neglect may alter the recognition of emotional faces, but its precise impact remains unclear. We aim to review and analyze data fr...

  • Article
  • Open Access
21 Citations
9,016 Views
19 Pages

Behavioral and Brain Activity Indices of Cognitive Control Deficits in Binge Drinkers

  • Sean M. Molnar,
  • Lauren E. Beaton,
  • Joseph P. Happer,
  • Lee A. Holcomb,
  • Siyuan Huang,
  • Donatello Arienzo and
  • Ksenija Marinkovic

Heavy episodic drinking is prevalent among young adults and is a public issue of increasing importance. Its initiation and maintenance are associated with deficits in the capacity to inhibit automatic processing in favor of non-habitual responses. Th...

  • Article
  • Open Access
22 Citations
8,214 Views
22 Pages

Rational explanation is ubiquitous in psychology and social sciences, ranging from rational analysis, expectancy-value theories, ideal observer models, mental logic to probabilistic frameworks, rational choice theory, and informal “folk psychological...

  • Article
  • Open Access
19 Citations
10,118 Views
17 Pages

28 December 2017

Children with fetal alcohol spectrum disorder (FASD) exhibit behavioral dysregulation, executive dysfunction, and atypical function in associated brain regions. Previous research shows early intervention mitigates these outcomes but corresponding bra...

  • Article
  • Open Access
11 Citations
2,158,810 Views
11 Pages

27 December 2017

We investigated whether anxious individuals, who adopt an inherently negative mindset, demonstrate a particularly salient memory bias for words tainted by negative contexts. To this end, sequentially presented target words, overlayed onto negative or...

  • Article
  • Open Access
51 Citations
7,430 Views
10 Pages

Extent of Resection in Newly Diagnosed Glioblastoma: Impact of a Specialized Neuro-Oncology Care Center

  • Amer Haj,
  • Christian Doenitz,
  • Karl-Michael Schebesch,
  • Denise Ehrensberger,
  • Peter Hau,
  • Kurt Putnik,
  • Markus J. Riemenschneider,
  • Christina Wendl,
  • Michael Gerken and
  • Martin A. Proescholdt
  • + 2 authors

25 December 2017

Treatment of glioblastoma (GBM) consists of microsurgical resection followed by concomitant radiochemotherapy and adjuvant chemotherapy. The best outcome regarding progression free (PFS) and overall survival (OS) is achieved by maximal resection. The...

  • Article
  • Open Access
20 Citations
7,301 Views
15 Pages

A Prospective Birth Cohort Study on Maternal Cholesterol Levels and Offspring Attention Deficit Hyperactivity Disorder: New Insight on Sex Differences

  • Yuelong Ji,
  • Anne W. Riley,
  • Li-Ching Lee,
  • Heather Volk,
  • Xiumei Hong,
  • Guoying Wang,
  • Rayris Angomas,
  • Tom Stivers,
  • Anastacia Wahl and
  • Xiaobin Wang
  • + 6 authors

23 December 2017

Growing evidence suggests that maternal cholesterol levels are important in the offspring’s brain growth and development. Previous studies on cholesterols and brain functions were mostly in adults. We sought to examine the prospective association bet...

  • Article
  • Open Access
27 Citations
7,808 Views
15 Pages

Adaptive Deep Brain Stimulation (aDBS) for Tourette Syndrome

  • Sara Marceglia,
  • Manuela Rosa,
  • Domenico Servello,
  • Mauro Porta,
  • Sergio Barbieri,
  • Elena Moro and
  • Alberto Priori

23 December 2017

Deep brain stimulation (DBS) has emerged as a novel therapy for the treatment of several movement and neuropsychiatric disorders, and may also be suitable for the treatment of Tourette syndrome (TS). The main DBS targets used to date in patients with...

  • Article
  • Open Access
3 Citations
6,190 Views
20 Pages

Disturbed Glucose Metabolism in Rat Neurons Exposed to Cerebrospinal Fluid Obtained from Multiple Sclerosis Subjects

  • Deepali Mathur,
  • Eva María-Lafuente,
  • Juan R. Ureña-Peralta,
  • Lucas Sorribes,
  • Alberto Hernández,
  • Bonaventura Casanova,
  • Gerardo López-Rodas,
  • Francisco Coret-Ferrer and
  • Maria Burgal-Marti

21 December 2017

Axonal damage is widely accepted as a major cause of permanent functional disability in Multiple Sclerosis (MS). In relapsing-remitting MS, there is a possibility of remyelination by myelin producing cells and restoration of neurological function. Th...

  • Review
  • Open Access
14 Citations
7,219 Views
10 Pages

Stimulation and Neuromodulation in the Treatment of Epilepsy

  • Timothy Marc Eastin and
  • Miguel Angel Lopez-Gonzalez

21 December 2017

Invasive brain stimulation technologies are allowing the improvement of multiple neurological diseases that were non-manageable in the past. Nowadays, this technology is widely used for movement disorders and is undergoing multiple clinical and basic...

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Brain Sci. - ISSN 2076-3425