Abstract
Inflammation, oxidative stress, and mitochondrial function are implicated in the development of obesity and its comorbidities. The purpose of this study was to assess the impact of weight loss through calorie restriction on the metabolic profile, inflammatory and oxidative stress parameters, and mitochondrial respiration in an obese population. A total of 109 subjects underwent two cycles of a very low-calorie diet alternated with a low-calorie diet (24 weeks). We analyzed biochemical and inflammatory parameters in serum, as well as oxidative stress markers, mRNA antioxidant gene expression, and mitochondrial respiration in peripheral blood mononuclear cells (PBMCs). After the intervention, there was an improvement in both insulin resistance and lipid profiles, including cholesterol subfractions. Weight loss produced a significant reduction in mitochondrial ROSs content and an increase in glutathione levels, coupled with an enhancement in the mRNA expression of antioxidant systems (SOD1, GSR, and CAT). In addition, a significant improvement in basal oxygen consumption, maximal respiration, and ATP production was observed. These findings demonstrate that moderate weight loss can improve insulin resistance, lipid profiles and subfractions, inflammatory and oxidative stress parameters, and mitochondrial respiration. Therefore, we can affirm that dietary intervention can simultaneously achieve significant weight loss and improve metabolic profile and mitochondrial function in obesity.
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MDPI and ACS Style
Bosch-Sierra, N.; Grau-del Valle, C.; Hermenejildo, J.; Hermo-Argibay, A.; Salazar, J.D.; Garrido, M.; Navajas-Porras, B.; Sáez, G.; Morillas, C.; Bañuls, C.
The Impact of Weight Loss on Inflammation, Oxidative Stress, and Mitochondrial Function in Subjects with Obesity. Antioxidants 2024, 13, 870.
https://doi.org/10.3390/antiox13070870
AMA Style
Bosch-Sierra N, Grau-del Valle C, Hermenejildo J, Hermo-Argibay A, Salazar JD, Garrido M, Navajas-Porras B, Sáez G, Morillas C, Bañuls C.
The Impact of Weight Loss on Inflammation, Oxidative Stress, and Mitochondrial Function in Subjects with Obesity. Antioxidants. 2024; 13(7):870.
https://doi.org/10.3390/antiox13070870
Chicago/Turabian Style
Bosch-Sierra, Neus, Carmen Grau-del Valle, Jonathan Hermenejildo, Alberto Hermo-Argibay, Juan Diego Salazar, Marta Garrido, Beatriz Navajas-Porras, Guillermo Sáez, Carlos Morillas, and Celia Bañuls.
2024. "The Impact of Weight Loss on Inflammation, Oxidative Stress, and Mitochondrial Function in Subjects with Obesity" Antioxidants 13, no. 7: 870.
https://doi.org/10.3390/antiox13070870
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