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Computation, Volume 10, Issue 4

2022 April - 19 articles

Cover Story: Computer simulations were performed for ivermectin and related compounds on three proteins of interest: (1) the spike glycoprotein of the SARS CoV-2 virus, (2) the CD147 receptor identified as a secondary attachment point for the virus, and (3) the alpha-7 nicotinic acetylcholine receptor, a potential point of viral penetration of neuronal tissue and an activation site for the cholinergic anti-inflammatory pathway. All three of these proteins are predicted to bind ivermectin with significant affinity. Our results suggest a mode of action of ivermectin, which may limit the infectivity of the SARS-CoV-2 virus and stimulate an α7nAChr-mediated anti-inflammatory pathway that could limit cytokine production by immune cells. View this paper
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Articles (19)

  • Article
  • Open Access
16 Citations
6,641 Views
17 Pages

In this paper, we introduce a penalized version of the geometric mean. In analogy with the Mazziotta Pareto Index, this composite indicator is derived as a product between the geometric mean and a penalization term to account for the unbalance among...

  • Article
  • Open Access
10 Citations
4,188 Views
12 Pages

Classifying the Degree of Bark Beetle-Induced Damage on Fir (Abies mariesii) Forests, from UAV-Acquired RGB Images

  • Tobias Leidemer,
  • Orou Berme Herve Gonroudobou,
  • Ha Trang Nguyen,
  • Chiara Ferracini,
  • Benjamin Burkhard,
  • Yago Diez and
  • Maximo Larry Lopez Caceres

Bark beetle outbreaks are responsible for the loss of large areas of forests and in recent years they appear to be increasing in frequency and magnitude as a result of climate change. The aim of this study is to develop a new standardized methodology...

  • Article
  • Open Access
12 Citations
3,841 Views
31 Pages

Modeling the Territorial Structure Dynamics of the Northern Part of the Volga-Akhtuba Floodplain

  • Inessa I. Isaeva,
  • Alexander A. Voronin,
  • Alexander V. Khoperskov and
  • Mikhail A. Kharitonov

The subject of our study is the tendency to reduce the floodplain area of regulated rivers and its impact on the degradation of the socio-environmental systems in the floodplain. The aim of the work is to create a new approach to the analysis and for...

  • Article
  • Open Access
8 Citations
5,211 Views
28 Pages

Co-Design of the Control and Power Stages of a Boost-Based Rectifier with Power Factor Correction Depending on Performance Criteria

  • Carlos Andres Ramos-Paja,
  • Andres Julian Saavedra-Montes and
  • Juan David Bastidas-Rodriguez

Rectifiers with power factor correction are key devices to supply DC loads from AC sources, guaranteeing a power factor close to one and low total harmonic distortion. Boost-based power factor correction rectifiers are the most widely used topology a...

  • Article
  • Open Access
14 Citations
3,627 Views
21 Pages

The aim of this study is to investigate the effects of temperature-dependent viscosity on the natural convection flow from a vertical permeable circular cone with uniform heat flux. As part of numerical computation, the governing boundary layer equat...

  • Article
  • Open Access
6 Citations
5,864 Views
17 Pages

An Alternative Methodology to Compute the Geometric Tortuosity in 2D Porous Media Using the A-Star Pathfinding Algorithm

  • Mayken Espinoza-Andaluz,
  • Javier Pagalo,
  • Joseph Ávila and
  • Julio Barzola-Monteses

Geometric tortuosity is an essential characteristic to consider when studying a porous medium’s morphology. Knowing the material’s tortuosity allows us to understand and estimate the different diffusion transport properties of the analyze...

  • Article
  • Open Access
3 Citations
3,355 Views
9 Pages

Despite the importance of seatbelt use in the reduction of injuries and fatalities, the majority of past studies failed to account for the complex nature of seatbelts on the safety of roadways. The complexity of seatbelt use is especially related to...

  • Article
  • Open Access
2 Citations
3,497 Views
12 Pages

Applying Machine Learning Methods and Models to Explore the Structure of Traffic Accident Data

  • Anton Sysoev,
  • Vladimir Klyavin,
  • Alexandra Dvurechenskaya,
  • Albert Mamedov and
  • Vladislav Shushunov

The problem of reducing the increasing number of road traffic accidents has become more relevant in recent years. According to the United Nations plan this number has to be halved by 2030. A very effective way to handle it is to apply the machine lea...

  • Article
  • Open Access
4 Citations
3,392 Views
24 Pages

Water is a basic necessity and one of the most valuable resources for human living. Sadly, large quantities of treated water get lost daily worldwide, especially in developing countries, through leaks in the water distribution network. Wireless senso...

  • Article
  • Open Access
9 Citations
7,451 Views
22 Pages

Shape Optimization of a Shell in Comsol Multiphysics

  • Evgenia Ermakova,
  • Timur Elberdov and
  • Marina Rynkovskaya

Optimization calculations are currently an actual and in-demand direction of computer-aided design. It allows not only the identification of the future characteristics of an object, but also the implementation of its exact model using a set of variou...

  • Article
  • Open Access
3 Citations
3,213 Views
18 Pages

Double Adaptive PI-Structure for Regulating a Microgrid DC Bus Using a Flyback-Based Battery Charger/Discharger Converter

  • Carlos Andres Ramos-Paja,
  • Juan David Bastidas-Rodriguez and
  • Andres Julian Saavedra-Montes

DC microgrids are composed of loads, renewable sources, and storage devices that require control and protection to operate safely. The flyback converter is an alternative to connect paralleled batteries with nominal voltage DC buses; however, until n...

  • Article
  • Open Access
4 Citations
3,987 Views
20 Pages

Continuous Simulation of the Power Flow in AC–DC Hybrid Microgrids Using Simplified Modelling

  • Oswaldo López-Santos,
  • María C. Salas-Castaño and
  • Diego F. Salazar-Dantonio

This paper reports the development of a model for continuous simulation of the power flow into AC–DC hybrid microgrids operating for different generation–consumption scenarios. The proposed application was assembled using a multiple-input...

  • Article
  • Open Access
12 Citations
9,977 Views
25 Pages

In Silico Analysis of the Multi-Targeted Mode of Action of Ivermectin and Related Compounds

  • Maral Aminpour,
  • Marco Cannariato,
  • Jordane Preto,
  • M. Ehsan Safaeeardebili,
  • Alexia Moracchiato,
  • Domiziano Doria,
  • Francesca Donato,
  • Eric Adriano Zizzi,
  • Marco Agostino Deriu and
  • Jack Adam Tuszynski
  • + 2 authors

Some clinical studies have indicated activity of ivermectin, a macrocyclic lactone, against COVID-19, but a biological mechanism initially proposed for this anti-viral effect is not applicable at physiological concentrations. This in silico investiga...

  • Review
  • Open Access
20 Citations
4,554 Views
14 Pages

Bibliometric analysis is the quantitative study of bibliographic material. In this paper, a systematic review of papers, authors, and journals is carried out. This is necessary to determine and set targets to be achieved in further research. The main...

  • Article
  • Open Access
5 Citations
5,247 Views
13 Pages

Educational production functions rely mostly on longitudinal data that almost always exhibit missing data. This paper contributes to a number of avenues in the literature on the economics of education and applied statistics by reviewing the theoretic...

  • Article
  • Open Access
7 Citations
2,828 Views
19 Pages

In many industries and plants, a stable power supply system with acceptable cost/benefit is essential. This paper investigates the cost-effectiveness of an unreliable retrial system that includes standby generators and experiences the switchover fail...

  • Article
  • Open Access
5 Citations
4,005 Views
15 Pages

Several financial instruments have been thoroughly calculated via the price of an underlying asset, which can be regarded as a solution of a stochastic differential equation (SDE), for example the moment swap and its exotic types that encourage inves...

  • Article
  • Open Access
2,957 Views
19 Pages

Recent studies have attempted to measure differences in lifestyle quality across the world. This paper contributes to this strand of literature by extending the indicator introduced in Milevsky (2020), i.e., “longevity-risk-adjusted global age&...

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Computation - ISSN 2079-3197