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Biosensors, Volume 9, Issue 3

2019 September - 30 articles

Cover Story: This research aims to minimize the power consumption of the organic optoelectronic pulse meter biosensor for long-term monitoring of the PPG waveforms wirelessly. A reflectance-type optoelectronic pulse meter composed of a red organic light-emitting diode (OLED) and an organic photodiode (OPD) fabricated monolithically on a glass substrate was proposed to measure the PPG signals. Two design structures with different OLED areas and gaps between an OLED and an OPD were examined for minimizing the power consumption and noise level of the biosensor pulse meter and evaluated using the PPG signal, which was successfully collected from a fingertip. The proposed reflectance-based organic pulse meter was operated successfully with an ultra-low power consumption down to 8 μW at 18 dB SNR, and with a clear PPG signal up to 46 dB SNR at a constant current of 93.6 μA. View this paper.
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Articles (30)

  • Article
  • Open Access
35 Citations
7,984 Views
17 Pages

Flexible PET/ITO/Ag SERS Platform for Label-Free Detection of Pesticides

  • Ariadna B. Nowicka,
  • Marta Czaplicka,
  • Aneta A. Kowalska,
  • Tomasz Szymborski and
  • Agnieszka Kamińska

19 September 2019

We show a new type of elastic surface-enhanced Raman spectroscopy (SERS) platform made of poly(ethylene terephthalate) (PET) covered with a layer of indium tin oxide (ITO). This composite is subjected to dielectric barrier discharge (DBD) that develo...

  • Review
  • Open Access
84 Citations
14,342 Views
25 Pages

Latest Trends in Biosensing for Microphysiological Organs-on-a-Chip and Body-on-a-Chip Systems

  • Sebastian Rudi Adam Kratz,
  • Gregor Höll,
  • Patrick Schuller,
  • Peter Ertl and
  • Mario Rothbauer

19 September 2019

Organs-on-chips are considered next generation in vitro tools capable of recreating in vivo like, physiological-relevant microenvironments needed to cultivate 3D tissue-engineered constructs (e.g., hydrogel-based organoids and spheroids) as well as t...

  • Article
  • Open Access
3 Citations
5,764 Views
16 Pages

Characterization of Binding of Magnetic Nanoparticles to Rolling Circle Amplification Products by Turn-On Magnetic Assay

  • Sobhan Sepehri,
  • Björn Agnarsson,
  • Teresa Zardán Gómez de la Torre,
  • Justin F. Schneiderman,
  • Jakob Blomgren,
  • Aldo Jesorka,
  • Christer Johansson,
  • Mats Nilsson,
  • Jan Albert and
  • Alexei Kalaboukhov
  • + 2 authors

17 September 2019

The specific binding of oligonucleotide-tagged 100 nm magnetic nanoparticles (MNPs) to rolling circle products (RCPs) is investigated using our newly developed differential homogenous magnetic assay (DHMA). The DHMA measures ac magnetic susceptibilit...

  • Article
  • Open Access
8 Citations
5,772 Views
14 Pages

16 September 2019

New technologies, such as biosensors and lab-on-a-chip, are reducing time consumption and costs for the detection and characterization of biological cells. One challenge is to detect and characterize cells and bacteria one by one or at a very low con...

  • Article
  • Open Access
8 Citations
5,217 Views
9 Pages

5 September 2019

The electrochemical reactor microbial sensor with the Clark oxygen electrode as the transducer was used for investigation of the competition between 3-chlorobenzoate (3-CBA) and its analogues, 2- and 4-chlorobenzoate (2-CBA and 4-CBA), for 3-chlorobe...

  • Article
  • Open Access
13 Citations
10,234 Views
13 Pages

Wireless Direct Microampere Current in Wound Healing: Clinical and Immunohistological Data from Two Single Case Reports

  • George Lagoumintzis,
  • Zoi Zagoriti,
  • Mogens S. Jensen,
  • Theodoros Argyrakos,
  • Constantinos Koutsojannis and
  • Konstantinos Poulas

5 September 2019

Chronic pressure ulcers are hard-to-heal wounds that decrease the patient’s quality of life. Wireless Micro Current Stimulation (WMCS) is an innovative, non-invasive, similar to electrode-based electrostimulation (ES) technology, that generates...

  • Article
  • Open Access
12 Citations
10,340 Views
20 Pages

Evaluation of In-Flow Magnetoresistive Chip Cell—Counter as a Diagnostic Tool

  • Manon Giraud,
  • François-Damien Delapierre,
  • Anne Wijkhuisen,
  • Pierre Bonville,
  • Mathieu Thévenin,
  • Gregory Cannies,
  • Marc Plaisance,
  • Elodie Paul,
  • Eric Ezan and
  • Guénaëlle Jasmin-Lebras
  • + 3 authors

31 August 2019

Inexpensive simple medical devices allowing fast and reliable counting of whole cells are of interest for diagnosis and treatment monitoring. Magnetic-based labs on a chip are one of the possibilities currently studied to address this issue. Giant ma...

  • Article
  • Open Access
9 Citations
7,501 Views
18 Pages

29 August 2019

Glyphosate, the most widely used pesticide worldwide, is under debate due to its potentially cancerogenic effects and harmful influence on biodiversity and environment. Therefore, the detection of glyphosate in water, food or environmental probes is...

  • Article
  • Open Access
22 Citations
7,464 Views
13 Pages

28 August 2019

Conductive polymers, owing to their tunable mechanical and electrochemical properties, are viable candidates to replace metallic components for the development of biosensors and bioelectronics. However, conducting fibers/wires fabricated from these i...

  • Review
  • Open Access
59 Citations
19,527 Views
30 Pages

23 August 2019

Alkaline phosphatase (ALP), which catalyzes the dephosphorylation process of proteins, nucleic acids, and small molecules, can be found in a variety of tissues (intestine, liver, bone, kidney, and placenta) of almost all living organisms. This enzyme...

  • Book Review
  • Open Access
6 Citations
5,334 Views
4 Pages

22 August 2019

A book entitled “Advances in Nanosensors for Biological and Environmental Analysis” published by Elsevier in 2019, is reviewed carefully and critically in this report. In this book, editors explored nanotechnology assisted approaches to d...

  • Article
  • Open Access
18 Citations
7,665 Views
13 Pages

14 August 2019

Diabetes Mellitus is a growing global concern. The current methods used to detect glycated haemoglobin are precise, however, utilise expensive equipment, reagents and consumables. These are luxuries which rural communities cannot access. The nanotech...

  • Article
  • Open Access
3 Citations
5,455 Views
14 Pages

Dielectrophoresis Multipath Focusing of Microparticles through Perforated Electrodes in Microfluidic Channels

  • Anas Alazzam,
  • Mohammad Al-Khaleel,
  • Mohamed Kamel Riahi,
  • Bobby Mathew,
  • Amjad Gawanmeh and
  • Vahé Nerguizian

7 August 2019

This paper presents focusing of microparticles in multiple paths within the direction of the flow using dielectrophoresis. The focusing of microparticles is realized through partially perforated electrodes within the microchannel. A continuous electr...

  • Article
  • Open Access
17 Citations
7,492 Views
12 Pages

6 August 2019

An electrocatalytic screen-printed sensor has been investigated for the measurement of the biologically important biomolecule vitamin B1 (thiamine) for the first time in food supplements. Under basic conditions, the vitamin was converted to its elect...

  • Article
  • Open Access
16 Citations
7,819 Views
13 Pages

Multimodal Device for Real-Time Monitoring of Skin Oxygen Saturation and Microcirculation Function

  • Uldis Rubins,
  • Zbignevs Marcinkevics,
  • Janis Cimurs,
  • Inga Saknite,
  • Edgars Kviesis-Kipge and
  • Andris Grabovskis

2 August 2019

The present study introduces a recently developed compact hybrid device for real-time monitoring of skin oxygen saturation and temperature distribution. The prototype involves a snapshot hyperspectral camera, multi-wavelength illuminator, thermal cam...

  • Article
  • Open Access
10 Citations
7,082 Views
15 Pages

The Presence of Polysaccharides, Glycerol, and Polyethyleneimine in Hydrogel Enhances the Performance of the Glucose Biosensor

  • Marco Fois,
  • Paola Arrigo,
  • Andrea Bacciu,
  • Patrizia Monti,
  • Salvatore Marceddu,
  • Gaia Rocchitta and
  • Pier Andrea Serra

30 July 2019

The use of amperometric biosensors has attracted particular attention in recent years, both from researchers and from companies, as they have proven to be low-cost, reliable, and very sensitive devices, with a wide range of uses in different matrices...

  • Review
  • Open Access
28 Citations
10,408 Views
28 Pages

Bio-Recognition in Spectroscopy-Based Biosensors for *Heavy Metals-Water and Waterborne Contamination Analysis

  • Alessandra Aloisi,
  • Antonio Della Torre,
  • Angelantonio De Benedetto and
  • Rosaria Rinaldi

30 July 2019

Microsystems and biomolecules integration as well multiplexing determinations are key aspects of sensing devices in the field of heavy metal contamination monitoring. The present review collects the most relevant information about optical biosensors...

  • Article
  • Open Access
48 Citations
9,015 Views
15 Pages

28 July 2019

Leafy vegetables have been associated with high-profile outbreaks causing severe illnesses. Timely and accurate identification of potential contamination is essential to ensure food safety. A surface plasmon resonance (SPR) assay has been developed f...

  • Article
  • Open Access
9 Citations
6,043 Views
9 Pages

Preparation and Characterization of Perforated SERS Active Array for Particle Trapping and Sensitive Molecular Analysis

  • István Rigó,
  • Miklós Veres,
  • Tamás Váczi,
  • Eszter Holczer,
  • Orsolya Hakkel,
  • András Deák and
  • Péter Fürjes

25 July 2019

A gold-coated array of flow-through inverse pyramids applicable as substrate for entrapment and immobilization of micro-objects and for surface enhanced Raman spectroscopic measurements was fabricated using bulk micromachining techniques from silicon...

  • Article
  • Open Access
25 Citations
7,105 Views
12 Pages

23 July 2019

This report is dedicated to development of surface-enhanced Raman spectroscopy (SERS) based analysis protocol for detection of antibiotics in urine. The key step of the protocol is the pretreatment of urine before the detection to minimize background...

  • Article
  • Open Access
18 Citations
7,417 Views
14 Pages

Design and Evaluation of a Non-Contact Bed-Mounted Sensing Device for Automated In-Home Detection of Obstructive Sleep Apnea: A Pilot Study

  • Clara Mosquera-Lopez,
  • Joseph Leitschuh,
  • John Condon,
  • Chad C. Hagen,
  • Uma Rajhbeharrysingh,
  • Cody Hanks and
  • Peter G. Jacobs

22 July 2019

We conducted a pilot study to evaluate the accuracy of a custom built non-contact pressure-sensitive device in diagnosing obstructive sleep apnea (OSA) severity as an alternative to in-laboratory polysomnography (PSG) and a Type 3 in-home sleep apnea...

  • Article
  • Open Access
12 Citations
7,360 Views
14 Pages

Diazonium-Modified Screen-Printed Electrodes for Immunosensing Growth Hormone in Blood Samples

  • Nan Li,
  • Ari M. Chow,
  • Hashwin V. S. Ganesh,
  • Melanie Ratnam,
  • Ian R. Brown and
  • Kagan Kerman

17 July 2019

Altered growth hormone (GH) levels represent a major global health challenge that would benefit from advances in screening methods that are rapid and low cost. Here, we present a miniaturized immunosensor using disposable screen-printed carbon electr...

  • Review
  • Open Access
170 Citations
23,021 Views
16 Pages

Towards Lateral Flow Quantitative Assays: Detection Approaches

  • Alexandr E. Urusov,
  • Anatoly V. Zherdev and
  • Boris B. Dzantiev

17 July 2019

Point-of-care (POC) or bedside analysis is a global trend in modern diagnostics. Progress in POC testing has largely been provided by advanced manufacturing technology for lateral flow (immunochromatographic) test strips. They are widely used to rapi...

  • Article
  • Open Access
36 Citations
16,292 Views
13 Pages

Reflectance-Based Organic Pulse Meter Sensor for Wireless Monitoring of Photoplethysmogram Signal

  • Fahed Elsamnah,
  • Anubha Bilgaiyan,
  • Muhamad Affiq,
  • Chang-Hoon Shim,
  • Hiroshi Ishidai and
  • Reiji Hattori

10 July 2019

This paper compares the structural design of two organic biosensors that minimize power consumption in wireless photoplethysmogram (PPG) waveform monitoring. Both devices were fabricated on the same substrate with a red organic light-emitting diode (...

  • Review
  • Open Access
254 Citations
18,192 Views
19 Pages

The Role of Electrochemical Immunosensors in Clinical Analysis

  • Fariba Mollarasouli,
  • Sevinc Kurbanoglu and
  • Sibel A. Ozkan

An immunosensor is a kind of affinity biosensor based on interactions between an antigen and specific antigen immobilized on a transducer surface. Immunosensors possess high selectivity and sensitivity due to the specific binding between antibody and...

  • Article
  • Open Access
41 Citations
9,567 Views
14 Pages

Cyclic Olefin Copolymer Microfluidic Devices for Forensic Applications

  • Brigitte Bruijns,
  • Andrea Veciana,
  • Roald Tiggelaar and
  • Han Gardeniers

Microfluidic devices offer important benefits for forensic applications, in particular for fast tests at a crime scene. A large portion of forensic applications require microfluidic chip material to show compatibility with biochemical reactions (such...

  • Article
  • Open Access
75 Citations
9,598 Views
12 Pages

Development of a Label-Free Electrochemical Aptasensor for the Detection of Tau381 and its Preliminary Application in AD and Non-AD Patients’ Sera

  • Dan Tao,
  • Bingqing Shui,
  • Yingying Gu,
  • Jing Cheng,
  • Weiying Zhang,
  • Nicole Jaffrezic-Renault,
  • Shizhen Song and
  • Zhenzhong Guo

30 June 2019

The electrochemical aptamer sensor has been designed for detecting tau381, a critical biomarker of Alzheimer′s disease in human serum. The aptasensor is obtained by immobilizing the aptamer on a carboxyl graphene/thionin/gold nanoparticle modif...

  • Article
  • Open Access
12 Citations
7,435 Views
15 Pages

Plasmonic Detection of Glucose in Serum Based on Biocatalytic Shape-Altering of Gold Nanostars

  • Masauso Moses Phiri,
  • Danielle Wingrove Mulder and
  • Barend Christiaan Vorster

29 June 2019

Nanoparticles have been used as signal transducers for optical readouts in biosensors. Optical approaches are cost-effective with easy readout formats for clinical diagnosis. We present a glucose biosensor based on the biocatalytic shape-altering of...

  • Article
  • Open Access
25 Citations
7,743 Views
11 Pages

EMG-Based Characterization of Walking Asymmetry in Children with Mild Hemiplegic Cerebral Palsy

  • Francesco Di Nardo,
  • Annachiara Strazza,
  • Alessandro Mengarelli,
  • Stefano Cardarelli,
  • Andrea Tigrini,
  • Federica Verdini,
  • Alberto Nascimbeni,
  • Valentina Agostini,
  • Marco Knaflitz and
  • Sandro Fioretti

27 June 2019

Hemiplegia is a neurological disorder that is often detected in children with cerebral palsy. Although many studies have investigated muscular activity in hemiplegic legs, few EMG-based findings focused on unaffected limb. This study aimed to quantif...

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Biosensors - ISSN 2079-6374