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Volume 12
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10.3390/plants12010146
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Article

Mulberroside F from In Vitro Culture of Mulberry and the Potential Use of the Root Extracts in Cosmeceutical Applications

by
Jiralapat Thamrongwatwongsa
1,
Nattaya Pattarapipatkul
1,
Titiradsadakorn Jaithon
1,
Ananya Jindaruk
1,
Atchara Paemanee
2,
Nattanan Panjaworayan T-Thienprasert
1 and
Wannarat Pornsiriwong Phonphoem
1,*
1
Department of Biochemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand
2
Metabolomics Research Team, National Omics Center, National Science and Technology Development Agency, Pathum Thani 12120, Thailand
*
Author to whom correspondence should be addressed.
Plants 2023, 12(1), 146; https://doi.org/10.3390/plants12010146
Submission received: 1 November 2022 / Revised: 21 December 2022 / Accepted: 23 December 2022 / Published: 28 December 2022
(This article belongs to the Special Issue New Insight into Research in In Vitro Plants Propagation)
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Abstract

Mulberry (Morus spp.) is primarily used in sericulture, and its uses also extend to the food, pharmaceutical, and cosmetic industries. Mulberry extracts are rich in many bioactive compounds that exhibit a wide range of biological properties. Mulberroside F (Moracin M-6, 3′-di-O-β-D-glucopyranoside), one of the bioactive compounds found in mulberry, has previously been reported as a whitening agent by inhibiting melanin synthesis and exhibiting antioxidant effects. However, there is still limited information on the presence of this compound in plants cultured in vitro. In this study, the mulberroside F content, biochemical, and cytotoxic properties of the extracts from mulberry cultured in vitro were determined. The results revealed that both root and callus were found to be a potential source of mulberroside F. Furthermore, the mulberroside F content was positively correlated with the inhibitory effects on tyrosinase activity. Cell viability assay also revealed that crude extract of the mulberry root has no cytotoxicity in both human keratinocyte cell line (HaCaT) and Vero cells. Taken together, mulberry tissue culture represents a possible alternative and continuous production of mulberroside F, which could be further utilized in cosmeceutical applications.
Keywords: anti-tyrosinase; callus; cytotoxicity; mulberroside F; Morus spp. anti-tyrosinase; callus; cytotoxicity; mulberroside F; Morus spp.
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MDPI and ACS Style

Thamrongwatwongsa, J.; Pattarapipatkul, N.; Jaithon, T.; Jindaruk, A.; Paemanee, A.; T-Thienprasert, N.P.; Phonphoem, W.P. Mulberroside F from In Vitro Culture of Mulberry and the Potential Use of the Root Extracts in Cosmeceutical Applications. Plants 2023, 12, 146. https://doi.org/10.3390/plants12010146

AMA Style

Thamrongwatwongsa J, Pattarapipatkul N, Jaithon T, Jindaruk A, Paemanee A, T-Thienprasert NP, Phonphoem WP. Mulberroside F from In Vitro Culture of Mulberry and the Potential Use of the Root Extracts in Cosmeceutical Applications. Plants. 2023; 12(1):146. https://doi.org/10.3390/plants12010146

Chicago/Turabian Style

Thamrongwatwongsa, Jiralapat, Nattaya Pattarapipatkul, Titiradsadakorn Jaithon, Ananya Jindaruk, Atchara Paemanee, Nattanan Panjaworayan T-Thienprasert, and Wannarat Pornsiriwong Phonphoem. 2023. "Mulberroside F from In Vitro Culture of Mulberry and the Potential Use of the Root Extracts in Cosmeceutical Applications" Plants 12, no. 1: 146. https://doi.org/10.3390/plants12010146

APA Style

Thamrongwatwongsa, J., Pattarapipatkul, N., Jaithon, T., Jindaruk, A., Paemanee, A., T-Thienprasert, N. P., & Phonphoem, W. P. (2023). Mulberroside F from In Vitro Culture of Mulberry and the Potential Use of the Root Extracts in Cosmeceutical Applications. Plants, 12(1), 146. https://doi.org/10.3390/plants12010146

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