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Review

Molecular Links between Flowering and Abiotic Stress Response: A Focus on Poaceae

by
Daniele Chirivì
and
Camilla Betti
*
Department of Biosciences, University of Milan, Via Celoria 26, 20133 Milan, Italy
*
Author to whom correspondence should be addressed.
Plants 2023, 12(2), 331; https://doi.org/10.3390/plants12020331
Submission received: 30 November 2022 / Revised: 4 January 2023 / Accepted: 4 January 2023 / Published: 10 January 2023
(This article belongs to the Special Issue New Challenges for Understanding the Molecular Regulation of Plant Developmental Processes)
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Abstract

:
Extreme temperatures, drought, salinity and soil pollution are the most common types of abiotic stresses crops can encounter in fields; these variations represent a general warning to plant productivity and survival, being more harmful when in combination. Plant response to such conditions involves the activation of several molecular mechanisms, starting from perception to signaling, transcriptional reprogramming and protein modifications. This can influence the plant’s life cycle and development to different extents. Flowering developmental transition is very sensitive to environmental stresses, being critical to reproduction and to agricultural profitability for crops. The Poacee family contains some of the most widespread domesticated plants, such as wheat, barley and rice, which are commonly referred to as cereals and represent a primary food source. In cultivated Poaceae, stress-induced modifications of flowering time and development cause important yield losses by directly affecting seed production. At the molecular level, this reflects important changes in gene expression and protein activity. Here, we present a comprehensive overview on the latest research investigating the molecular pathways linking flowering control to osmotic and temperature extreme conditions in agronomically relevant monocotyledons. This aims to provide hints for biotechnological strategies that can ensure agricultural stability in ever-changing climatic conditions.

Graphical Abstract

1. Introduction

Due to their sessile nature, plants cannot move away from unfavorable circumstances they encounter throughout their life cycle. For this reason, they must ensure immediate and coordinated stress response by modulating the expression and activity of several molecular players, from membrane receptors to transcription factors [1,2,3,4]. In fact, the plant response to abiotic stress is a multilevel process based on an intricate coordination of signal transduction pathways. In addition, it takes place in different subcellular compartments (cytosol, chloroplasts, mitochondria and peroxisomes), involving distinct second messengers (e.g., ROS and Ca2+) and protein-modifying enzymes (e.g., kinases and phosphatases) [4,5,6].
Stress-driven metabolic and transcriptional reprogramming of plant cells usually leads to a global response that ultimately affects plant physiology and development, mainly by means of phytohormones mediation, first of all abscisic acid (ABA) [5,7,8]. In angiosperms, the transition from the vegetative to the reproductive stage, referred to as flowering or heading, is crucial to ensure evolutionary success, and its timing and development are strongly regulated under unfavorable growing conditions. Indeed, exposure to abiotic stress during flower development would have deleterious effects on pollen viability and grain filling, threatening reproductive success and causing production losses in agricultural species [9,10]. Evolution and domestication have made plants adapt to abiotic stress by anticipating or delaying flowering, according to species-specific reproductive strategies [11]. In the model species A. thaliana, the cross-talk between the stress-signalling and the flowering regulatory pathways has been extensively reviewed, whereas, for other species, such as cultivated monocotyledons, information is more dispersed [12,13,14]. Cereals, belonging to the monocotyledon family of Poaceae, hold a great agricultural and economic impact, representing a primary food source for the world population and a major livestock feed [15,16].
Five cereal species sustain most of the human and animal nutritional needs and have therefore been extensively studied: wheat (Triticum aestivum L.), barley (Hordeum vulgare L.), rice (Oryza sativa L.), maize (Zea mays L.) and sorghum (Sorghum bicolor L.). According to the Food and Agriculture Organization, world production during 2020 reached 761, 157, 756, 1162 and 58 million tons for wheat, barley, rice, maize and sorghum, respectively [17]. Their productivity, as well as for other crops, relies on a successful transition from the vegetative to the reproductive and grain-filling phases [18].
Understanding cereal responses to different environmental events is crucial to boost their productivity and to ensure their resilience under stressful conditions. Floral initiation and its timing are tightly synchronized and controlled by genetic networks that integrate environmental cues as photoperiod and temperature [19]. In cultivated grasses, floral transition must occur at a very specific time (seasoning), in order to avoid deleterious stresses and foster a high grain yield [20,21].
Favorable flowering times differ between temperate and tropical cereals. The latter, including many rice varieties, preferentially flower under short day (SD) conditions to avoid pernicious high temperatures associated with the long-days (LD) season [22]. Conversely, temperate species generally flower under LD conditions (spring or summer) [21]. Amid the two categories, day-neutral crops, such as maize, do not have specific photoperiodic requirements for flowering, which is triggered by the activation of autonomous regulatory pathways [18].
Flowering-regulating genes can control many different traits, including seed formation and fertility. In cultivated monocotyledons, genetic variability of these genes has been associated with variations in productivity and plant survival under different climatic conditions [23,24,25,26,27]. This review aims at summarizing the currently available information to underline the molecular interconnection existing between photoperiodic flowering induction and the exposure to unfavorable atmospheric and soil conditions in cereals.
Drought, extreme temperatures and the excess of soil salinity are increasingly determining factors for productivity during the next decades, due to climate change [28]. Having a comprehensive overview of the genes and proteins involved in the control of heading time in cereals in response to specific abiotic stresses could help better define new biotechnological and breeding targets to improve their productivity in the field.

2. Molecular Regulators of Flowering Time in Monocotyledons

From the molecular point of view, monocotyledons share elements of an exclusive flowering-controlling pathway that integrates specific regulators with the A. thaliana GIGANTEA-CONSTANS-FLOWERING LOCUS T (GI-CO-FT) reference model [14,29].
In rice, CO homologue Heading date 1 (Hd1) functionally differentiated in order to work in a counterposed manner (both as flowering repressor and promoter), depending on the photoperiod. Other important monocotyledon flowering regulators have different roles with respect to their A. thaliana homologues: for example, wheat and barley Photoperiod 1 (Ppd-1), rice PSEUDO-RESPONSE REGULATOR37 (OsPRR37) and sorghum SbPRR37, all flowering repressors, are homologous to A. thaliana PRR37, a pseudo-response regulator that has a role in the circadian clock, but not in flowering induction [30,31,32,33]. Similarly, temperate cereals VERNALIZATION 1 (VRN1), an MADS-box gene involved in the vernalization process, is homologous to A. thaliana APETALA 1 (AP1), whose role in flower development is only downstream of environmental induction [34,35]. On the other hand, grass-specific flowering regulators are numerous and include the homologous flowering repressors Grain number, Plant Height, and Heading date1 (Ghd7) in rice and sorghum, barley vernalization regulator VRN2, and maize CONSTANS, CONSTANS-LIKE AND TOC1 (ZmCCT) [36,37,38].
In all cereals, the leaf-to-shoot mobilization of florigenic proteins, belonging to the phosphatidyl ethanolamine-binding protein (PEBP) family, and the formation of presumed florigen activation complexes, are the final output of photoperiodic flowering induction and the starting point for terminal shoot differentiation and floral organs development [39,40,41]. Cereals’ FT-like proteins include rice Hd3a and RFT1, Z. mays CENTRORADIALIS 8 (ZCN8) and 12, SbFT1, 8 and 10 in sorghum and HvFT/TaFT/VRN3 in barley and wheat [42,43,44,45,46].

3. Stress Factors and Flowering Response

3.1. Water Availability

In cereals, the effect of water availability on flowering time and yield broadly differs among species, being the result of the adaption to distinct edaphic and climatic conditions.
An excess of water in soil, known as water-logging, accelerates flowering in rice, but delays it in sorghum [47,48]. A general yield decrease, as a consequence of flooding, characterizes all rainfed crops, such as sorghum, maize and wheat [49,50]. Rice, instead, is often cultivated as a semiaquatic plant, requiring controlled land flooding, so that water excess is not normally considered as a stressful condition, unless it leads to submergence, thereby impairing photosynthesis and flowering [51].
Flooding is perceived by plant roots as a condition of general oxygen reduction (hypoxia), which alters the redox environment inside of the mitochondria [52]. In A. thaliana and cultivated monocotyledons, the systemic response to flooding mainly relies on the ethylene signalling pathway [52,53,54,55]. To the best of our knowledge, no in-depth studies on the molecular connection between the response to flooding and flowering induction in cereals have been conducted so far.
Conversely, much more data are available on the interplay between drought response and flowering, possibly because extreme drought events tend to represent a greater threat to agricultural production [56,57]. Prolonged water deficit causes a delay in the reproductive transition in most cereals [58,59]. In barley and wheat, drought-driven changes in flowering time and harvesting parameters are related to the genotypical seasonality [60]. These crops are cultivated in cold to temperate climates, where a winter season is clearly defined. Varieties that are sown in autumn, and harvested in summer, are called winter varieties, whereas those sown in spring, to be harvested in autumn, are called spring varieties and do not require vernalization [36]. A study conducted on barley has shown that spring and winter varieties react to drought in the pre-anthesis stages with a general heading delay, though the degree of such delay depends on the genotype and its photoperiodical requirements. However, harvest losses were reduced in early-flowering spring varieties [60].
The molecular link existing between floral induction and osmotic stress response has been deeply studied in A. thaliana, a facultative LD-flowering plant. A major role has been attributed to the clock component GI, positively regulating CO expression, which in turn promotes the transcription of the florigen FT. Under inductive photoperiodic conditions and drought stress, GI mediates the ABA-dependent mechanism of “drought escape”, directly or indirectly activating FT expression to accelerate flowering [61,62].
In rice, the transcription of the monocotyledon-specific floral promoter Early Heading Date 1 (Ehd1) and of the two florigens Hd3a and RFT1 are reduced by drought treatment under inductive photoperiodic conditions [63]. Rice GI homologue, OsGI, is a mild floral repressor controlling the expression of Hd1, an important flowering repressor under LD [64]. Rice osgi mutants are early flowering and show higher drought tolerance than the wildtype, as well as an upregulation of genes related to oxidative-stress response and protein stabilization [65,66,67,68]. Some researchers, however, have attributed to Ehd1 a more important role than OsGI in the integration of drought stimuli into the flowering pathway [63] (Figure 1).
Rice floral repressor Ghd7 has been reported to control various plant traits in addition to heading date, such as drought tolerance. Just as osgi mutants, Ghd7 knockdown lines are early flowering and show increased drought tolerance, whereas Ghd7-overexpressing plants are more sensitive to water deprivation [69,70].
Overexpression of the ZmCCT, the maize homologue of rice Ghd7, delays flowering under LD and drought treatment, but also confers higher drought tolerance [71,72]. It could be hypothesized that Ghd7/ZmCCT participation in both flowering induction and drought stress response is conserved in monocotyledons, even if the specific gene function could vary between the two species.
In maize, ZmCCT regulates the expression of a number of genes belonging to the floral induction pathway and to the circadian clock, such as ZmCOL9 and maize CIRCADIAN CLOCK ASSOCIATED 1 (ZmCCA1), respectively. ZmCCA1 is an important clock component in maize and a positive regulator of a set of genes related to the general stress response, such as those encoding for the flagellin receptor FLS2 or the MAP kinases MKK1 and 2 [73,74,75,76]. OsCCA1 has been recently associated with ABA signalling and the response to multiple abiotic stresses [77]. Conversely, the transcription of above-mentioned Ghd7 is repressed both by drought and ABA treatments [69,70]. However, the interplay between these two genes under drought conditions needs yet to be clarified.
NUCLEAR FACTOR (NF-Y) transcription factors are another notable set of proteins that regulate heading date in cereals. NF-Y proteins are widespread among eucaryotes, controlling multiple developmental and stress-related processes through the formation of DNA-binding heterotrimers [78,79,80]. In flowering plants, the formation of NF-Y complexes is required to regulate the expression of florigenic genes. A. thaliana CO and rice Hd1 work as NF-YA subunits inside of NF-Y trimers, binding to FT/Hd3a promoter regions and activating gene transcription [81,82]. Interaction of NF-Y transcription factors with flowering and vernalization regulators (VRN2 and CO2) has also been reported in Triticum monococcum wheat [83].
A. thaliana NF-C3, NF-C4, and NF-C9 subunits have been shown to interact with ABA-responsive element-binding factors (ABFs) to enhance SUPPRESSOR OF OVEREXPRESSOR OF CONSTANS1 (SOC1) transcription and so induce flowering under drought stress [84]. Maize transcription factor NF-YA3 interacts with FLOWERING PROMOTING FACTOR 1 (ZmFPF1) and the CCT protein ZmCO-like to promote flowering by binding to ZmFT-like12 promoter [85]. Moreover, ZmNF-YA3 is able to bind to the promoters of a set of ABA-related transcription factors and to physically interact with MYC4, a protein belonging to the jasmonic acid (JA) signaling cascade [85].
In temperate cereals, barley Ppd-1 is an important hub for the integration of drought response into the control of flowering time. Indeed, Ppd-1 is, together with the vernalization gene VRN1, the main quantitative trait associated with yield variability in relation to harsh climatic conditions in barley [27,86,87]. Under inductive photoperiodic conditions, Ppd-H1 promotes flowering by enhancing the expression of a set of downstream genes, such as HvFT1, VRN1 and MADS-box 3 (BM3). The barley Ppd-1 promoter region contains ABA-responsive elements (ABREs), and gene transcription in enhanced by osmotic stress, similar to some A. thaliana PRRs [88,89]. Many high-latitudes barley varieties carry a Ppd-1 version that encodes for a protein with a mutated CCT domain. Flowering is consequently delayed, generating a favorable trait for harvesting in colder climates. On the other hand, these varieties tend to be less drought tolerant: under suboptimal hydric conditions, the delay of heading date is larger and spike development is impaired [90]. These findings lead to thinking that Ppd-1 could mediate the response to water deficit during reproductive development. Flowering pathways in barley and wheat are very similar [31,32,91]; therefore, it is possible that a similar model is also valid for wheat, but this is still a speculation.
MiRNAs also have an important function in the regulation of drought response in plants [92,93]. In A. thaliana, GI promotes the processing of miR172, which targets a set of FT repressors to facilitate flowering during drought escape [29,94,95,96]. In rice, maize and barley, miR172s take part in the determination of floral identity and spikelet differentiation by targeting the transcripts of AP2 orthologs [97,98,99,100]. After drought treatment, miR172 target gene Glossy15 (GL15) is downregulated in maize [101]. However, there are no studies describing how miR172 might simultaneously connect drought stress and reproductive development networks in these crops.
OsmiR393 occupies an overlapping position, influencing both floral commitment and drought response, presumably through a modulation of auxin sensitivity in leaves and other organs. OsmiR393 negatively regulates auxin perception by targeting the auxin receptors OsTIR1 and OsAFB2, similarly to their A. thaliana homologues [102,103]. While a higher tillering rate and early flowering result from OsTIR1 and OsAFB2 repression, it is yet not known how this affects abiotic stress tolerance. Different research works have shown that higher miR393 levels are associated with lower salt and drought resistance both in rice and A. thaliana, but studies using a combined approach in rice are still missing [103,104,105] (Figure 1).

3.2. Temperature Extremes

Temperature thresholds for optimal plant growth largely vary among species. Wheat optimal range, out of which the plant perceives a temperature stress, is 17–23 °C [106]. The same parameter for rice and maize ranges between 13–35 °C and 6–42 °C, respectively [107]. Based on lethal temperatures, it is evident that wheat has a lower heat tolerance than rice, which is the most sensitive to low temperatures, whereas maize shows the largest optimal thermal range [91,106,107].
One of the most important features of temperate cereals is the adaptation to cold climates through the evolution of vernalization. Vernalization is a molecular mechanism ensuring that flowering takes place after the winter has passed, i.e., in warm and long days when the risk of frosting is lower. Vernalization is also present in dicotyledons, but it has most probably evolved independently more than once across evolution [108].
In A. thaliana, exposure to prolonged low temperatures and consequent upregulation of the vernalization gene VERNALIZATION INSENSITIVE 3 (VIN3) results in the de-repression of flowering through epigenetic inactivation of the MADS-box transcription tactor FLOWERING LOCUS C (FLC), which otherwise inhibits the transition to the reproductive stage [109].
In vernalizing cereals, control of vernalization is based on a conserved set of three genes: VRN1, VRN2 and VRN3. VRN2, a Ghd7 homologue, is a flowering repressor under LD, and suppresses VRN3 expression before vernalization. After a long cold exposure, VRN1 is upregulated, inactivating VRN2 and de-repressing VRN3, which in turn enhances VRN1 expression in a positive loop that brings the floral transition [14,46,110,111].
Although vernalization is required for proper life cycle both in A. thaliana and in temperate cereals, those species can also be sensitive to freezing temperatures. In A. thaliana, in fact, cold resistance of gi mutants is suppressed by knockout of CYCLING DOF FACTORS (CDFs). This suggests that GI and CDFs, which exert a combined control of CO expression, may also regulate the response to low temperatures, as demonstrated by transcriptomic data on differentially expressed genes in these mutants [112]. In T. monococcum, a set of COLD-REGULATED (COR) genes is regulated by VRN1, in a photoperiod-dependent way: they are upregulated under SD and downregulated under LD conditions [113].
Rice has adapted over history to cultivation at high latitudes, although it is a tropical plant in origin. Regardless of the photoperiod, low temperatures delay heading date in this species [114]. Oryza japonica subspecies carries a Ghd8 promoter allele that increases gene expression, presumably predisposing it to endure colder climates [26]. Ghd8 is a NF-YB subunit and a flowering repressor, and its overexpression has indeed been recently correlated to increased cold tolerance and transcription of cold responsive genes [26] (Figure 1).
It must be noted that increasing temperatures associated with climate change may represent a greater challenge to cereal production than frosting events in the upcoming decades [115].
In A. thaliana, high temperatures induce early flowering. Temperature-driven upregulation of FT in the leaf results from an interplay of ELF3, CO and the transcription factor PHYTOCHROME-INTERACTING FACTOR 4 (PIF4) [91,116,117,118].
In Poaceae, as for other types of stress, the scenario is not uniform [60,119,120,121]. In Brachypodium dystachion, a monocotyledon model species, heading is delayed at temperatures that are both lower or higher than the optimal one, although the intensity of the phenotype is accession-dependent [122].
In rice, higher temperatures accelerate heading under SD by enhancing Hd3a expression, but this does not happen under LD conditions, indicating that temperature-mediated flowering promotion is dependent on the photoperiod [114,123].
In barley, a shift to higher temperatures during the vegetive phase promotes flowering under inductive conditions (LD) and delays it under non-inductive ones (SD). This response pattern is dependent on the MADS-box floral repressor HvODDSOC2 (HvOS2), which is upregulated at high temperatures under SD condition. OS2 genes are specific of grasses and show only a weak similarity to A. thaliana SOC1. Both wheat, barley and B. distachyon OS2 orthologues are downregulated by cold treatment, suggesting that convergence of both photoperiod- and temperature-dependent flowering regulating functions might be phylogenetically conserved [124,125,126].
Barley differential response to rising temperatures in terms of heading date has been also attributed to already-mentioned Ppd-1, as well as to HvELF3: mutation of the former delays flowering under high temperatures, while mutation in the latter, a repressor of Ppd-1, accelerates it [127]. Because Ppd-1 is upstream of VRN1 and HvODDSOC2, it could be inferred that an entire section of the flowering induction pathway is modulated in response to temperature variations to orient heading date in barley.
Finally, coordination between photoperiod and temperature sensing to control floral induction is mediated by the lectin-like gene TaVER2 and its barley homologue. The transcripts of the two genes increase with vernalization but decrease under high temperature and SD conditions [128].
A major risk of heat stress during reproductive development is permanent damage to floral organs. Maximum anthesis temperatures reach 32 °C in wheat and 37 °C in rice and maize: beyond these points, yield losses and seed sterility are substantial [91,106,107]. Many monocotyledons, such as wheat, sorghum and millet, have adapted flower opening in order to occur in early morning or late evening, when temperatures are lower [129]. The qEMF locus has been identified as responsible for advancing the flower opening to early morning in Oryza officinalis and represents a trait of agronomical interest to reduce heat-born damages to floral organs in domesticated rice [130].

3.3. Soil Salinity

Soil salinity is an especially relevant problem in coastal agricultural areas, and its magnitude is expected to increase due to the rising of sea levels and saltwater intrusion. Among other factors, waste-water contamination and excessive fertilization can also cause soil salinization [131].
Studies on halophytic plants have shown that tolerance to NaCl often correlates with a higher ability to cope with heavy metal soil pollution, a phenomenon that is of growing environmental interest. In fact, salinity stress has both an osmotic and an ionic component, and at least part of plant tolerance processes is expected to be common between these two types of abiotic stress [132,133,134].
Among cereals, rice exhibits a high sensitivity to salt, which delays heading and impairs the development of reproductive organs [135]. For its biological and agronomical interest, salt tolerance mechanisms in rice have been the subject of extensive research [55,135,136,137,138].
A. thaliana GI and its rice homologue OsGI have both been correlated to NaCl homeostasis. In A. thaliana, GI degradation under salt stress triggers a post-translational regulation pathway that activates the ion transporter SOS1, increasing cell tolerance to salt excess [139]. Analogously, OsGI is presumably targeted by a putative rice evening complex, composed by the rice clock proteins EARLY FLOWERING4 A (OsELF4A), OsELF3 and LUX ARRHYTHMO (OsLUX). Single mutants of the three complex components exhibit reduced salt tolerance and delayed heading date, while osgi mutants show the opposite phenotype. Higher salt tolerance in the latter coincides with the upregulation of genes encoding for ion transporters, such as OsHAK1 and OsHAK5 [140].
In rice, OsPRR73, another clock component, has lastly been described as a positive regulator of salt tolerance in rice, yet with no link to flowering [141]. On the other hand, rice RECEPTOR FOR ACTIVATED C KINASE 1 A (OsRACK1A), a clock-regulated gene, delays heading while it suppresses salt response by repression of stress-related genes [142]. OsRACK1A has an expression peak during the day, but night transcript levels increase during salt stress. Protein stability could be controlled post-translationally, since it is phosphorylated under ABA treatment and drought conditions. Curiously, OsRACK1A accumulation peak coincides with that of OsGI, at 8–10 h from day start, suggesting that the two proteins could undergo a common diurnal control [142] (Figure 1, Table 1).
As for other stresses, transcriptional control of protein-coding genes in response to salinity does not represent the whole scenario. The role of miRNAs in salt stress tolerance has been elucidated in rice and maize. Previously mentioned OsmiR393 decreases tolerance to salt and alkaline stress, similarly to OsmiR396, which, on the other hand, has not been related to any flowering trait [143]. In maize, miR164s downregulation after salt treatment leads to enhanced expression of their degradation targets, which include members of the NAC transcription factor family. MiR164s are involved in the regulation of many developmental processes in plants, mainly by defining organ boundaries during meristem differentiation [117,118,144]. Distinct studies confirm the importance of miR164s and their target genes to define meristem boundaries also in rice, as well as their function in response to heavy metals and osmotic stress [120,121,140].
It can be hypothesized that miR164s work as a bridge between organ specification and abiotic stress response. The existence of a link between these two seemingly separate areas of plant biology is corroborated by a growing number of publications [145,146]. In rice, knockdown of OsCKX2, an inflorescence meristem-specific cytokinin oxidase, increases cytokinin levels during panicle development and confers high salt stress tolerance. Moreover, since OsCKX2 is a negative regulator of branching, productivity-related parameters, such as branch and grain number, are enhanced in RNAi lines, to a greater extent under salinity stress [147] (Figure 1). Adaptation to high salt concentrations during flower development, far downstream of the photoperiodic induction pathway, is essential to overcome toxic effects on the development of reproductive organs, which are well documented in crops [138,148,149].
Unfortunately, in temperate cereals, the molecular players of salt stress response in relation to flowering regulation have not been studied in depth. In wheat and barley, NaCl is excluded from the floral apex under high salinity conditions. This notwithstanding, reproductive development and productivity are equally affected: salt-treated plants are early flowering and produce a reduced number of spikelets and grains [148] (Figure 1). Field studies on different barley accessions point at an existing correlation between photoperiodic responsiveness and tolerance to abiotic stresses, such as drought and salinity, in association with the allelic variability of the flowering time genes Ppd-1, Sdw1, VRN1 and VRN3 [27]. It is highly probable that these genes’ functions are transversal to different physiological processes, as demonstrated in the case of heading and drought stress response.

4. Conclusions and Perspectives

In this review, the role of important monocotyledon regulators of abiotic stress response and flowering induction has been addressed (Table 1).
Although the focus here has been mainly on photoperiodic-responsive genes controlling the timing of the reproductive phase, a global response to abiotic stress vehiculated by downstream events, such the formation of the florigen activation complexes in the shoot apical meristem prior to the reproductive differentiation, may take place.
Florigens accomplish their regulatory function through the interaction with a group of bZip transcription factors, homologous to A. thaliana FD [41,42,46,150].
Among the bZIP family, many TFs are linked to ABA-mediated abiotic stress response [151]. In rice, for example, OsbZIP72 is a positive regulator of ABA response and drought tolerance [152]. In addition, OsbZIP46 overexpression improves drought tolerance, participating in ABA response [153]. OsbZIP23, 66 and 72 are, instead, involved in the regulation of ABA-mediated seed germination via interaction with OsMFT2 (MOTHER OF FT AND TERMINAL FLOWER 1), which belongs to the PEBP family [154].
In A. thaliana, bZIPs associated with ABA signalling have been also shown to participate in flowering regulation upstream of the vernalization gene FLC [155]. Future investigations in this direction could help with dissecting the role of bZIP transcription factors in vernalization and abiotic stress response in temperate cereals.
Finally, a relevant position between flowering control and abiotic stress response might be taken by post-translational modifications (PTMs). PTMs are an essential component of the complex interaction network on which plants rely to adapt to environmental stresses. Through the addition of small chemical groups, PTMs regulate protein subcellular localization and/or interactions with other proteins [4,156,157,158]. Ubiquitination, which is crucial to control proteins abundance in cells, has been reported to contribute to the acquisition of stress tolerance in plants [159]. In rice, for example, the role of E3-ubiquitin ligases, and of their interacting proteins, in association with drought response has been largely studied. Nevertheless, no sufficient data are available to establish a link with flowering [160,161].
Reversible protein phosphorylation induced by abiotic stresses such as salinity or drought is known to influence cereal productivity by causing growth delays or fertility impairment. Moreover, phosphoproteomics analyses have identified several kinases or kinase-interacting proteins that are involved in male-sterility processes [157,162,163,164,165].
Table
Table 1. Main flowering regulators of Poaceae integrating abiotic stress signalling into the heading control and flower developmental pathways.
Table 1. Main flowering regulators of Poaceae integrating abiotic stress signalling into the heading control and flower developmental pathways.
RegulatorSpeciesStressRole in FloweringReference
OsGIRiceDrought, salinityRepressor[64,68,140]
Ehd1RiceDroughtPromoter[63]
OsELF4aRiceSalinityPromoter[140]
OsELF3RiceSalinityPromoter[140]
OsLUXRiceSalinityPromoter[140]
Ghd7RiceDroughtRepressor[70]
OsRACK1ARiceSalinityRepressor[142]
OsCKX2RiceSalinityPanicle Development[147]
Ghd8RiceColdRepressor[26]
miR393RiceDrought, salinityPromoter[102,103]
miR172Rice, maize, barleyDroughtPanicle Development[97,99,101,166]
ZmCCTMaizeDroughtRepressor[71,72]
NF-YA3MaizeDroughtPromoter[85]
miR164Maize, riceSalinity, droughtMeristem differentiation[167]
Ppd-1BarleyDrought, heatPromoter[90,127]
HvVRN1BarleyHeatVernalization/Promoter[125,126,127]
HvODDSOC2BarleyHeatRepressor[125,126]
VRN1T. monococcumColdVernalization/Promoter[113]
BdVIL4B. dystachionHeatVernalization/Promoter[168]
The issue of soil nutrient availability in relation to plant reproductive development has not been addressed in this review. Evidence exists that the plant nutritional status influences flowering and grain-filling phases in cereals [91]. Even if soil nutrient imbalance is certainly a major source of abiotic stress for plants, specific deficiencies can be often handled with cultivation techniques. Obviously, these applications are not that effective in mitigating unpredictable weather episodes and extreme environmental phenomena.
It is a fact that climate change has negative effects on cereals lifecycle and productivity, and that the frequency of severe heat, drought, or salinity events is growing at a high pace. Considerable yield decreases and geographically determined changes in crop phenology are amongst the expected effects of such extreme events [28].
Considering the current scenario of constantly changing climate conditions, a more detailed understanding of how abiotic stress variables affect the molecular control of flowering in cereals is important for their future biotechnological optimization and to improve productivity in the field.

Author Contributions

Conceptualization, D.C. and C.B.; writing—original draft preparation and revision, D.C and C.B.; All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Data Availability Statement

No new data were created or analyzed in this study. Data sharing is not applicable to this article.

Conflicts of Interest

The authors declare no conflict of interest.

References

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Figure 1. Rice flowering under abiotic stress. Drought, salt or extreme temperature stimuli converge on endogenous flowering regulators to modulate heading and floral organs development in Oryza sativa. Some of the major regulators involved in stress responses are indicated in italics; see text for additional details.
Figure 1. Rice flowering under abiotic stress. Drought, salt or extreme temperature stimuli converge on endogenous flowering regulators to modulate heading and floral organs development in Oryza sativa. Some of the major regulators involved in stress responses are indicated in italics; see text for additional details.
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Chirivì, D.; Betti, C. Molecular Links between Flowering and Abiotic Stress Response: A Focus on Poaceae. Plants 2023, 12, 331. https://doi.org/10.3390/plants12020331

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Chirivì D, Betti C. Molecular Links between Flowering and Abiotic Stress Response: A Focus on Poaceae. Plants. 2023; 12(2):331. https://doi.org/10.3390/plants12020331

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Chirivì, Daniele, and Camilla Betti. 2023. "Molecular Links between Flowering and Abiotic Stress Response: A Focus on Poaceae" Plants 12, no. 2: 331. https://doi.org/10.3390/plants12020331

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Chirivì, D., & Betti, C. (2023). Molecular Links between Flowering and Abiotic Stress Response: A Focus on Poaceae. Plants, 12(2), 331. https://doi.org/10.3390/plants12020331

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