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Article

Biological Activities of the Fruit Essential Oil, Fruit, and Root Extracts of Ferula drudeana Korovin, the Putative Anatolian Ecotype of the Silphion Plant †

by
Fatma Tosun
1,*,
Fatih Göger
2,
Gökalp İşcan
3,
Mine Kürkçüoğlu
3,
Fadıl Kaan Kuran
4 and
Mahmut Miski
4,*
1
Department of Pharmacognosy, School of Pharmacy, İstanbul Medipol University, İstanbul 34083, Turkey
2
Department of Pharmaceutical Botany, Faculty of Pharmacy, Afyonkarahisar Health Sciences University, Afyonkarahisar 03030, Turkey
3
Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey
4
Department of Pharmacognosy, Faculty of Pharmacy, İstanbul University, İstanbul 34116, Turkey
*
Authors to whom correspondence should be addressed.
†
Dedicate this publication to the victims of the February 6th South-East Anatolia Earthquake.
Plants 2023, 12(4), 830; https://doi.org/10.3390/plants12040830
Submission received: 31 December 2022 / Revised: 26 January 2023 / Accepted: 8 February 2023 / Published: 13 February 2023
(This article belongs to the Special Issue Phytochemical and Nutritional Analyses of Medicinal and Aromatic Plants (MAP))
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Abstract

In the present study, preliminary phytochemical investigations were performed on the fruit essential oil and antioxidant-rich methanolic extracts of the fruits and roots of Ferula drudeana, the putative Anatolian ecotype of the Silphion plant, to corroborate its medicinal plant potential and identify its unique characteristics amongst other Ferula species. The essential oil from the fruits of the endemic species Ferula drudeana collected from Aksaray was analyzed by GC and GC/MS. The main components of the oil were determined as shyobunone (44.2%) and 6-epishyobunone (12.6%). The essential oil of the fruits and various solvent extracts of the fruits and roots of F. drudeana were evaluated for their antibacterial and anticandidal activity using microbroth dilution methods. The essential oil of the fruits, methanol, and methylene chloride extracts of the fruits and roots showed weak to moderate inhibitory activity against all tested microorganisms with MIC values of 78–2000 µg/mL. However, the petroleum ether extract of the roots showed remarkable inhibitory activity against Candida krusei and Candida utilis with MIC values of 19.5 and 9.75 µg/mL, respectively. Furthermore, all the samples were tested for their antioxidant activities using DPPH• TLC spot testing, online HPLC–ABTS screening, and DPPH/ABTS radical scavenging activity assessment assays. Methanolic extracts of the fruits and roots showed strong antioxidant activity in both systems.
Keywords: Ferula drudeana; GC/MS; HPLC–ABTS•+; essential oil; antibacterial; anticandidal; antioxidant Ferula drudeana; GC/MS; HPLC–ABTS•+; essential oil; antibacterial; anticandidal; antioxidant

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MDPI and ACS Style

Tosun, F.; Göger, F.; İşcan, G.; Kürkçüoğlu, M.; Kuran, F.K.; Miski, M. Biological Activities of the Fruit Essential Oil, Fruit, and Root Extracts of Ferula drudeana Korovin, the Putative Anatolian Ecotype of the Silphion Plant. Plants 2023, 12, 830. https://doi.org/10.3390/plants12040830

AMA Style

Tosun F, Göger F, İşcan G, Kürkçüoğlu M, Kuran FK, Miski M. Biological Activities of the Fruit Essential Oil, Fruit, and Root Extracts of Ferula drudeana Korovin, the Putative Anatolian Ecotype of the Silphion Plant. Plants. 2023; 12(4):830. https://doi.org/10.3390/plants12040830

Chicago/Turabian Style

Tosun, Fatma, Fatih Göger, Gökalp İşcan, Mine Kürkçüoğlu, Fadıl Kaan Kuran, and Mahmut Miski. 2023. "Biological Activities of the Fruit Essential Oil, Fruit, and Root Extracts of Ferula drudeana Korovin, the Putative Anatolian Ecotype of the Silphion Plant" Plants 12, no. 4: 830. https://doi.org/10.3390/plants12040830

APA Style

Tosun, F., Göger, F., İşcan, G., Kürkçüoğlu, M., Kuran, F. K., & Miski, M. (2023). Biological Activities of the Fruit Essential Oil, Fruit, and Root Extracts of Ferula drudeana Korovin, the Putative Anatolian Ecotype of the Silphion Plant. Plants, 12(4), 830. https://doi.org/10.3390/plants12040830

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