Green Innovation and Synthesis of Honeybee Products-Mediated Nanoparticles: Potential Approaches and Wide Applications
Abstract
:1. Introduction
2. Method of Search
3. Bee Products and Their Metabolites
3.1. Honey
3.2. Propolis
3.3. Bee Pollen
3.4. Bee Bread
3.5. Royal Jelly
3.6. Beeswax
3.7. Bee Venom
4. Green Synthesis of NPs Utilizing Bee Products
4.1. Sliver Nanoparticles (AgNPs)
4.1.1. Utilizing Honey for AgNP Synthesis
4.1.2. Utilizing Propolis for AgNPs’ Synthesis
4.1.3. Utilizing BP for AgNPs’ Synthesis
4.1.4. Utilizing Bee Bread for AgNPs’ Synthesis
4.1.5. Utilizing Royal Jelly for AgNPs Synthesis
4.2. Gold Nanoparticles (AuNPs)
4.2.1. Utilizing Honey for Gold Nanoparticles’ (AuNPs) Synthesis
4.2.2. Utilizing Propolis for Gold Nanoparticles’ (AuNPs) Synthesis
Nanoparticles | Bee Products/Reducing and Capping Agents | Morphology | NPs Size (nm) | Biological Activities and Application | References |
---|---|---|---|---|---|
Gold nanoparticles (AuNPs) | Propolis/Carboxyl groups in the propolis component | Spherical | 7.8 | Anticancer activity | [99] |
(Au@AgNPs) | Propolis/Polyphenolic molecules | Spherical | 108 | Antibacterial and anticancer activity | [44] |
AuNPs | Propolis/Polyphenols, proteins, vitamins, and sugars | Spherical, hexagonal, and triangular | 20–60 | Catalytic and anti-tumor activity | [42] |
AuNPs@ZnO | Propolis | Spherical | 22–73 | Antibacterial activity and cytotoxicity properties against human breast cancer cell line (MCF-7) and liver carcinoma cell line (HepG2). | [48] |
Palladium nanoparticles (PdNPs) | Propolis/Flavonoid | Crystalline phase and face-centered cubic structure | 3.14–4.62 | Anticancer and antimicrobial | [41] |
Selenium nanoparticles (SeNPs) | Propolis/Phenolic content | Spherical | 279 | Antibacterial activity | [49] |
SeNPs | Propolis/Flavones, steroids, phosphoric acid, charcones, acetic acid, butanol, butyl ester, butanoic acid, hydroxyl and keto waxes, ketones, terpenoids, and sugars | Spherical | 50–60 | Antioxidant activity | [102] |
SeNPs | Propolis/Alcohol and polyphenols | Crystalline, oval, and with smooth surface | 52.9–118 | Antioxidant and antimicrobial potential | [103] |
Copper nanoparticles (CuNPs) | Propolis/Proteins, sugars, and polyphenols | Spherical | 15–23 | N.D. | [43] |
CuO NPs | Propolis | Crystallite | 75–145 and 120–155 | Antimicrobial, and cytotoxic effects | [47] |
Iron oxide nanoparticles (IONPs) | Propolis | Spherical | Around 87 and 194 | Antibacterial activity and degradation of dyes | [45] |
Titanium oxide nanoparticles (TiO2NPs) | flavonoids and phenolic compounds | Quasi-spherical | 21 | Antimicrobial activity | [46] |
calcium oxide nanoparticles (CaONPs) | Honey/Hydroxyl and carboxylic groups, amines, and amides | Spherical | >100 | Antifungal activity and cytotoxicity properties | [104] |
Decahedral cinnamon nanoparticles | Honey/Vitamins, proteins, monosaccharide, and fructose | Crystalline | 17.08 ± 4.71 | Antibacterial activity | [105] |
Cerium oxide anoparticles (CeO2NPs) | Honey/Proteins and carbohydrates | Spherical | 1.23 | Antioxidant and photocatalytic dye degradation | [106] |
CeO2NPs | Honey/Proteins and carbohydrates | Spherical | 2.61 | Antioxidant and photocatalytic dye degradation | [106] |
CeO2NPs | Honey/Proteins and carbohydrates | Spherical | 3.02 | Antioxidant and photocatalytic dye degradation | [106] |
Graphene basedNiO2/Cu2O nanocomposite (Gr@NiO2/Cu2O NCs) | Honey/Reducing sugar | Crystalline | 15 | Catalyst in synthesizing the functionalized Schiff-base derivatives | [107] |
Chromium oxide nanoparticles (Cr2O3NPs) | Honey/Proteins, and carbohydrates | Crystalline | 20 | Antioxidant and anti-inflammatory activity | [108] |
Cr2O3NPs | Honey/Carbohydrates | Crystalline | 24.7205 | Antioxidant and antibacterial activity | [109] |
CoFe2O4, Ag dopedNPs | Honey | Crystallite | 24–41 | Antibacterial activity | [110] |
Platinum nanoparticles (PtNPs) | Honey/Protein | Crystalline | 5–15 | Catalytic application on preparation of organic dye | [8] |
Zinc oxide nanoparticles (ZnONPs) | Honey/Fructose, glucose, sucrose, proteins, minerals, and vitamins. | Crystalline | 39 | Catalytic, antibacterial, and antifungal activities | [111] |
ZnONPs | Propolis | Spherical | 17–70 | Antibacterial activity, cytotoxicity properties against cell lines (MCF-7 and HepG2). | [48] |
NiFe2O4 spinel ferriteNPs | Honey/Glucose and fructose | Octahedral | 10–70 | Magnetic, dielectric, and electrical properties | [112] |
Carbon Nanoparticles (CNPs) | Honey/Monosaccharides and the higher sugars | Spherical | Below 7 | - | [113] |
AgNPs@ZnO | Propolis | Spherical | 45–75 | Antibacterial activity, cytotoxicity properties against cell lines (MCF-7 and HepG2). | [48] |
BP@MgNPs | Bee pollen | Spherical | 36–40 | Antioxidant and antibacterial activity | [53] |
4.2.3. Bee Pollen for Gold Nanoparticles (AuNPs) Synthesis
4.3. Bee Pollen for Magnesium Nanoparticle (MgNPs) Synthesis
4.4. Bee Bread for Iron Nanoparticles (FeNPs) Synthesis
5. Biological Activities of Bee Products-Mediated Nanoparticles
5.1. Anticancer
5.2. Antibacterial
6. Application of Bee Products-Mediated Nanoparticles
6.1. Catalysis Application
6.2. Food Industries
7. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Acknowledgments
Conflicts of Interest
References
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Bee products Used/Reducing and Capping Agents | Morphology | NPs Size (nm) | Biological Activities and Application | References |
---|---|---|---|---|
Utilizing honey for silver nanoparticles (AgNPs) synthesis | ||||
Honey/Honey | Spherical | 9–22 | Inhibitory effect on aflatoxins and ochratoxin | [69] |
Honey/Glucose | Spherical | >20 | [75] | |
Proteins, minerals, and polyphenols | Spherical with smooth edges | 50–98 | Antioxidant, cytotoxic, and antibacterial agent | [76] |
Honey/Glucose, fructose, organic acids, vitamins, and minerals | Spherical | 14.3 and 14.7 | Antibacterial properties with inhibition zone of 14 mm against Staphylococcus aureus | [26] |
Honey/Phenolic compounds, fructose, glucose, vitamins, and proteins | Spherical | 42.7 | Cytotoxic effect against L-929 cell line and antibacterial activity | [28] |
Honey/Honey (black seed) | Spherical | 25–70 | Antibacterial activity | [77] |
Honey/Fructose, glucose, and vitamin C | Spherical and monodispersed | 5–25 | Catalytic degradation of methylene blue | [27] |
Honey/Alkane, ketone, alkene, nitro compounds, vinyl ether, and alkyl halide | Spherical | 50–90 | Anticancer, antimicrobial, immunomodulatory | [78] |
Honey/Vinyl ether, alkene, and bromo compounds | Spherical | 70–80 | Antimicrobial, immunomodulatory, and cytotoxic activities | [79] |
Honey/Fructose and proteins | Spherical | N.D. | Anticorrosion potentials for mild steel in acidic environments | [80] |
Honey | Crystalline | 11.1 | - | [81] |
Utilizing propolis for AgNPs’ synthesis | ||||
Propolis/Polyphenols and flavonoids | Crystalline | 91 | Anticancer | [40] |
Propolis/Quercetin and galangin | Spherical | 16.5 ± 5.3 | Antimicrobial activity | [82] |
Propolis/Aliphatic –CH, –CH2 groups and carboxylate compounds in the propolis extract | N.D. | 108.2 | Antibacterial activity | [83] |
Propolis/Amino acids, flavonoids, and phenolics | Spherical | 8.7 | Potent antimicrobial and wound-healing composites | [84] |
Propolis/Polyol | N.D. | 2–40 | Antifungal, antibiofilm, and non-mutagenic properties | [85] |
Propolis | Spherical | 20 | Antimicrobial activity | [86] |
Propolis | Spherical | 13–45 | Immunomodulatory effect | [87] |
Propolis | N.D. | 5–15 | Antibacterial effects and catalytic activity | [88] |
Utilizing bee pollen (BP) for AgNPs’ synthesis | ||||
BP | Spherical | 11.5 | Antioxidant activity | [55] |
BP | Spherical | 10–30 | Anticancer activity and antioxidant activity | [89] |
BP | Spherical | 40–60 nm | Antidiabetic activity | [90] |
Utilizing bee bread (Bb) for AgNPs’ synthesis | ||||
Bb | Spherical | 48.3–150.1 | Antioxidant and antimicrobial activity | [91] |
Utilizing royal jelly (RJ) for AgNPs’ synthesis | ||||
RJ | Disk-like morphologies | 4 | Antimicrobial activity | [60] |
RJ | Spherical | 7.8–192.7 and 8.6–61.8 | Antimicrobial activity | [61] |
Parameters | Z. spina-christi Honey-Mediated AgNPs | A. gerrardii Honey-Mediated AgNPs | Amoxicillin | Cefuroxime | Ciprofloxacin |
---|---|---|---|---|---|
Average size (nm) | 50.5 ± 0.7 | 98.2 ± 0.9 | |||
Inhibition zone of Staphylococcus aureus (mm) | 19.4 ± 0.6 | 17.0 ± 0.1 | 20 ± 0.6 | 24 ± 0.9 | 22 ± 1.7 |
Inhibition zone of Escherichia coli (mm) | 22.8 ± 1.2 | 19.0 ± 1.3 | 18 ± 1.4 | 25 ± 1.9 | 34 ± 1.3 |
Inhibition zone of Pseudomonas aeruginosa (mm) | 21.0 ± 0.9 | 18.6 ± 0.8 | - | - | 35 ± 1.8 |
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Khalifa, S.A.M.; Shetaia, A.A.; Eid, N.; Abd El-Wahed, A.A.; Abolibda, T.Z.; El Omri, A.; Yu, Q.; Shenashen, M.A.; Hussain, H.; Salem, M.F.; et al. Green Innovation and Synthesis of Honeybee Products-Mediated Nanoparticles: Potential Approaches and Wide Applications. Bioengineering 2024, 11, 829. https://doi.org/10.3390/bioengineering11080829
Khalifa SAM, Shetaia AA, Eid N, Abd El-Wahed AA, Abolibda TZ, El Omri A, Yu Q, Shenashen MA, Hussain H, Salem MF, et al. Green Innovation and Synthesis of Honeybee Products-Mediated Nanoparticles: Potential Approaches and Wide Applications. Bioengineering. 2024; 11(8):829. https://doi.org/10.3390/bioengineering11080829
Chicago/Turabian StyleKhalifa, Shaden A. M., Aya A. Shetaia, Nehal Eid, Aida A. Abd El-Wahed, Tariq Z. Abolibda, Abdelfatteh El Omri, Qiang Yu, Mohamed A. Shenashen, Hidayat Hussain, Mohamed F. Salem, and et al. 2024. "Green Innovation and Synthesis of Honeybee Products-Mediated Nanoparticles: Potential Approaches and Wide Applications" Bioengineering 11, no. 8: 829. https://doi.org/10.3390/bioengineering11080829