Veterinary Sciences, Volume 9, Issue 10
October 2022 - 73 articles
- Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
- You may sign up for email alerts to receive table of contents of newly released issues.
- PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.
Cover Story: Osteosarcoma (OSA) is relatively common in dogs and shares many similarities with human OSA. In dogs, the tumors are frequently seen in large breeds and may be caused by environmental and genetic factors. Sex steroids have been shown to regulate bone metabolism through receptors on bone. The aim of this study was to characterize sex hormone receptor expression in naturally occurring canine OSA tissue and OSA cell lines. OSA subtypes expressed variable levels of sex hormone receptors, while the progesterone receptor (PR) was highly expressed in OSA cell lines. PR expression increased in hypoxic OSA cells. Our data show that sex hormone receptors exist in canine OSA tissue, indicating the potential for modulation by circulating hormones, particularly progesterone. View this paper