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BioChem, Volume 4, Issue 2

2024 June - 5 articles

Cover Story: Glioblastoma, the most common and aggressive type of malignant brain tumor, presents a poor prognosis due to the lack of effective treatment alternatives. This underscores the need for innovative therapeutic approaches. Sphingolipids, integral to the cell membrane and complement components, key to innate immunity, have been identified as crucial in glioblastoma survival signaling. This review focuses on recent studies that explore the functional roles of sphingolipid metabolism and complement activation signaling in glioblastoma, and the potential of a novel therapeutic approach that targets these systems in unison. View this paper
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Articles (5)

  • Article
  • Open Access
1 Citations
2,549 Views
22 Pages

Proteomic Blueprint of Atlantic Cod (Gadus morhua) Otoliths Revealing Environmental Stress Insights through Label-Free Quantitative Shotgun Proteomics

  • Trevena N. Youssef,
  • Sherri L. Christian,
  • Rick Rideout,
  • Aaron Adamack,
  • Pierre Thibault,
  • Eric Bonneil,
  • Travis D. Fridgen and
  • Joseph Banoub

19 June 2024

Otoliths of the fish’s inner ear serve as a natural chronological recorder because of their continuous formation marked by daily, monthly, and annual increments. Despite their importance, the comprehensive protein content of otoliths remains no...

  • Review
  • Open Access
2 Citations
3,888 Views
18 Pages

6 June 2024

Glioblastoma is the most common and aggressive type of malignant brain tumor with a poor prognosis due to the lack of effective treatment options. Therefore, new treatment options are required. Sphingolipids are essential components of the cell membr...

  • Communication
  • Open Access
2,633 Views
11 Pages

Novel Tetrazolium-Based Colorimetric Assay for Helicase nsp13 in SARS-CoV-2

  • Triet M. Pham,
  • Morgan G. Howard,
  • Shane M. Carey,
  • Lindsey R. Baker and
  • Edward L. D’Antonio

15 May 2024

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a human pathogenic virus that encodes for a helicase (SC2Hel) that is essential for viral replication. SC2Hel has the ability to unravel dsRNA or dsDNA in an NTP-dependent manner from th...

  • Review
  • Open Access
5 Citations
8,693 Views
25 Pages

16 April 2024

Metabolites are at the end of the gene–transcript–protein–metabolism cascade. As such, metabolomics is the omics approach that offers the most direct correlation with phenotype. This allows, where genomics, transcriptomics and prote...

  • Review
  • Open Access
4 Citations
6,481 Views
29 Pages

New Insights into Hsp90 Structural Plasticity Revealed by cryoEM

  • Karine Minari,
  • Vitor Hugo Balasco Serrão and
  • Júlio César Borges

4 April 2024

Heat Shock Protein 90 (Hsp90) acts as a crucial molecular chaperone, playing an essential role in activating numerous signaling proteins. The intricate mechanism of Hsp90 involving ATPase-coupled conformational changes and interactions with cochapero...

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BioChem - ISSN 2673-6411