Parasitic Nematodes in Animals: The Genomics, Control, and Drug Resistance

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: 15 June 2025 | Viewed by 821

Special Issue Editors


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Guest Editor
Department of Pharmacy, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China
Interests: veterinary pharmacology; antiparasitic drugs; pharmacodynamic mechanism; alternative antibiotics; safety evaluation; new veterinary drugs research
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Guest Editor
College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China
Interests: pharmacokinetics; antiparasitic drug; alternative antibiotics; preparation research

Special Issue Information

Dear Colleagues,

Animal nematodes are one of the causes of animal diseases. Animal nematode infections not only cause significant economic losses worldwide and affect wild population dynamics, but are also a global public health problem. The complex life history of animal nematodes and the influence of environmental factors such as climate, soil and drug pollution mean that nematodes are not well understood. Long-term use of anthelmintic drugs to control animal nematodes infecting livestock has led to the emergence of drug-resistant nematodes in both developed and developing countries. Therefore, there is an urgent need for further understanding of animal nematodes from genomics to support control strategies and the development of new drugs for animal nematodes.

In this issue, we will focus on the genomes, drug resistance and control measures of animal nematodes. Our scope includes the study of nematode genomes, environmental resistance, drug resistance and related molecular mechanisms, as well as the application of new drug studies or technologies that can reduce animal nematode burden and/or egg production.

We invite original research papers and reviews related to the above topics.

Prof. Dr. Keyu Zhang
Dr. Guoyong Wang
Guest Editors

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Keywords

  • nematode
  • genomics
  • drug resistance
  • resistant gene
  • molecular mechanism
  • drug development
  • treatment
  • breeding management
  • vaccine
  • clinical curative effect

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Published Papers (1 paper)

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Research

13 pages, 639 KiB  
Article
Occurrence of Internal Parasites and Anthelmintic Resistance in Goats
by Gianluca D’Amico, Adrian-Valentin Potârniche, Bianca-Irina Tucă and Adriana Györke
Animals 2025, 15(7), 1024; https://doi.org/10.3390/ani15071024 - 2 Apr 2025
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Abstract
Extensive anthelmintic (AH) use for endoparasitism prevention, especially gastrointestinal strongyle (GIS) infections, led to AH resistance (AR). This study assessed the internal parasitic profile and AR occurrence in goat herds. Five herds (H, n = 300) raised in household systems in Romania (2020–2021) [...] Read more.
Extensive anthelmintic (AH) use for endoparasitism prevention, especially gastrointestinal strongyle (GIS) infections, led to AH resistance (AR). This study assessed the internal parasitic profile and AR occurrence in goat herds. Five herds (H, n = 300) raised in household systems in Romania (2020–2021) were dewormed with eprinomectin in the fall (H1, H2) and albendazole in the spring (H3–H5). Fecal samples (n = 67) were collected pre- and 14 days post-AH administration. Coprological examinations, coprocultures, and polymerase chain reaction (PCR) were performed. Anthelmintic resistance was detected in H1, H2, and H5. Pre-AH administrations, Eimeria spp. was the most common parasite (95.5%), followed by GIS (91.0%), P. rufescens/M. capillaris (77.6%), Dyctiocaulus filaria (56.7%), and Moniezia spp. (43.3%). Teladorsagia circumcincta (4/5), Trichostrongylus colubriformis (4/5), Oesophagostomum venulosum (3/5), Haemonchus placei (3/5), Haemonchus contortus (2/5), and Cooperia oncophora (2/5) were identified by PCR. Mean OPG/EPG values for Eimeria spp. and GIS were <1000 eggs/gram feces, tending to be higher in young versus adult goats and in autumn versus spring. FECR (90%CI) values post-AH administration were 38.42 (23.4; 71.8), 54.71 (−4.1; 75.1) for eprinomectin, and 9.78 (−1.7; 64.8) for albendazole, suggesting AH ineffectiveness and AR presence in H1, H2, and H5, respectively. These findings highlight that specific management measures are needed. Full article
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