Helicobacter pylori Virulence Factors and Antibiotic Susceptibility
A special issue of Antibiotics (ISSN 2079-6382).
Deadline for manuscript submissions: closed (30 June 2020) | Viewed by 46461
Special Issue Editors
Interests: Gastroenterology; Helicobacter pylori; H. pylori virulence factors; host response to H. pylori infection; H. pylori-related extra-digestive diseases
Interests: gastroenterology; clinical and basic aspects of H. pylori; proteomics for dissecting the molecular basis of gastrointestinal diseases; clinical and basic aspects of Hepatitis C virus and B virus
Special Issue Information
Dear Colleagues,
Helicobacter pylori is a spiral organism that colonizes the human gastric and gastric-type mucosa. It is an agent of chronic gastritis (CG), the pabulum on which peptic ulceration, gastric mucosa atrophy and cancer may develop. Despite H. pylori being a primary pathogen, most infected individuals do not show any sign or symptom of infection throughout their lifetime. This prompted researchers to investigate the different isolates to ascertain which virulence factors (VFs) could enable the various strains to cause the most severe outcomes of infection. VF CagA and VacA are currently being investigated in depth, but other VFs may warrant being investigated more thoroughly. Some VFs show a stronger immune response and a more substantial local and systemic inflammatory status; they may also modify the gastric microbiome, and this activity may not be confined to the stomach. Some observations suggest that strains expressing CagA are more susceptible to antibiotics (An) and chemotherapeutic agents used to cure infection. In addition, some natural substances, used together with An, might help doctors to get rid of these organisms from the gastric mucosa. The aim of the present Special Issue is to publish state of art research regarding H. pylori VFs and chemo-susceptibility that may help physicians and researchers to select patients most suited for treatment and which drugs should be administered.
Dr. Natale Figura
Dr. Antonio Ponzetto
Guest Editors
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Keywords
- Antimicrobial drugs and therapies
- virulence factors
- CagA
- VacA
- pathogenesis
- host response
- extra-digestive diseases
- gastric microbioma
- pro-inflammatory cytokines
- chemosusceptibility
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