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Antibiotics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Membrane Disruptors: The Role of Antimicrobial Peptides in Combatting Pathogens

edited by

Andrea Mescola

submission deadline 30 Jun 2025 | Viewed by 134 | Submission Open

Keywords: antimicrobial peptides (AMPs); microbial resistance; drug-resistant pathogens; anticancer; antiviral; membrane disruption; membrane poration; permeabilization; lipids; peptide design and engineering

(This special issue belongs to the Section Antimicrobial Peptides)

Antimicrobial Extracts and Compounds Derived from Plants

edited by

Giovanna Simonetti

submission deadline 30 Jun 2025 | Viewed by 130 | Submission Open

Keywords: antibacterial; antifungal; plant extract; plant compounds; antibiotic-resistant strains; virulence factors; synergistic interactions

(This special issue belongs to the Section Plant-Derived Antibiotics)

Periodontal Bacteria and Periodontitis: Infections and Therapy

edited by Anna Skurska

submission deadline 30 Jun 2025 | Viewed by 83 | Submission Open

Keywords: periodontitis; infection; antibiotics; antibacterial activities

(This special issue belongs to the Section Antibiofilm Strategies)

Antimicrobial Stewardship in the Management of Bloodstream Infections

edited by

Zoran Todorovic

Gordana Dragović

and Saša Trailović

submission deadline 1 Jul 2025 | Viewed by 165 | Submission Open

Keywords: bloodstream infections; antimicrobial drugs; immunodeficiency; sepsis; antimicrobial resistance; therapeutic drug monitoring

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Antimicrobial Therapy in Oral Diseases

edited by

Alexandra Roman

and

Andrada Soanca

submission deadline 5 Jul 2025 | 3 articles | Viewed by 7994 | Submission Open

Keywords: oral; antibiotic; antiseptic; tooth; periodontium; dental caries; implant; healing; cell; biomaterials; periodontitis; biocompatibility; toxicity; periodontology; periodontal pocket; bacteria; nonsurgical treatment; oral surgery; clinical trial

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Epidemiology, Clinical Microbiology and Antimicrobial Therapy: A Shared Effort against Infectious Diseases

edited by Francesca Pica

submission deadline 15 Jul 2025 | 9 articles | Viewed by 13674 | Submission Open

Keywords: microbes and antimicrobials; bacteria; fungi and viruses; antibiotics; antifungals and antivirals; antimicrobial resistance; rapid diagnostics; genotypic and phenotypic resistance; epidemiology; public health; infectious diseases; hospital-acquired infections (HAIs); community infections; natural and synthetic antimicrobial compounds

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Epidemiology, Diagnosis and Antimicrobial Treatment of Hospital-Acquired Infections

edited by

Diamantis Kofteridis

and

Petros Ioannou

submission deadline 15 Jul 2025 | 3 articles | Viewed by 2964 | Submission Open

Keywords: hospital-acquired infection; bacteremia; bloodstream infection; pneumonia; ventilator-associated pneumonia; urinary tract infection

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Impact of Plant-Derived Products as Novel Antimicrobial Agents

edited by Eleonora Spinozzi

submission deadline 15 Jul 2025 | Viewed by 90 | Submission Open

Keywords: natural compounds; plant bacteria; fungal infections; antimicrobial

(This special issue belongs to the Section Plant-Derived Antibiotics)

Antimicrobial Activity of Bioactive Peptides and Their Derivatives

edited by Alexandro Rodríguez-Rojas

submission deadline 20 Jul 2025 | 5 articles | Viewed by 7199 | Submission Open

Keywords: antimicrobial resistance (AMR); global health threat; novel antimicrobial agents; bioactive peptides (AMPs); natural antimicrobial agents; broad-spectrum activity; antimicrobial activity; mechanisms of action; structure– activity relationships; AMP-based therapeutics; clinical applications of AMPs; combinatory therapy

(This special issue belongs to the Section Antimicrobial Peptides)

Plant Extracts and Natural Products for the Control of Animal Pathogens in a ONE-Health Perspective

edited by Ernesto Palma,

Roberto Bava

and Carmine Lupia

submission deadline 20 Jul 2025 | Viewed by 352 | Submission Open

Keywords: natural products; essential oils; hive products; colostrum; pets; livestock; drug resistances; antimicrobial resistances; sustainable pathogen control; animal health and welfare

(This special issue belongs to the Section Antibiotics in Animal Health)

Foodborne Pathogens: The Rise of Virulence and Antimicrobial Resistance

edited by

Luisa Brito

and

Acacio Salamandane

submission deadline 20 Jul 2025 | Viewed by 157 | Submission Open

Keywords: foodborne pathogens; antimicrobial resistance; virulence factors; food chain; antibiotic overuse; public health; food safety; zoonotic diseases; one health

Novel Approaches for the Treatment of Antimicrobial-Resistant Pathogens

edited by

Yosra A. Helmy

submission deadline 31 Jul 2025 | 2 articles | Viewed by 30881 | Submission Open

Keywords: antimicrobial resistance diagnosis and surveillance; antibiotic alternatives and development of novel drugs; whole-genome sequencing; gut microbiota; infectious pathogens in animals and humans

(This special issue belongs to the Section Novel Antimicrobial Agents)

Antibiotics and Environment − Research and Development toward the One Health Approach

edited by

Takashi Azuma

submission deadline 31 Jul 2025 | 7 articles | Viewed by 21077 | Submission Open

Keywords: antimicrobial resistance (AMR); antimicrobials; water purification plant (WTP); wastewater treatment plant (WWTP); hospital wastewater; livestock environment; aquaculture farm environment; aquatic environment

Antibiotics as Major Disruptors of Gut Microbiota

edited by

Gábor Ternák

submission deadline 31 Jul 2025 | 5 articles | Viewed by 17191 | Submission Open

Keywords: microbiome; gut flora; development of gut flora; dysbiosis; antibiotics; antibiotic classes; antibiotic consumption; gut– brain axis; short-chain fatty acids; metabolom; mediator molecules; composition of gut flora

Green Antimicrobials in Biomedical Engineering: Recent Advances Proposal

edited by

Helena Felgueiras

submission deadline 31 Jul 2025 | 6 articles | Viewed by 12451 | Submission Open

Keywords: antimicrobial agents concomitant; synergistic and additive effects surface functionalization; antimicrobial properties; biomedical therapies; bioactive molecules; green synthesis; environmentally friendly; circular economy; waste materials’ second life

(This special issue belongs to the Section Novel Antimicrobial Agents)

Antibiotic Treatment on Surgical Infections

edited by

Fausto Catena

submission deadline 31 Jul 2025 | 3 articles | Viewed by 11908 | Submission Open

Keywords: surgical site; infection; emergency surgery; prevention

Alternative Approaches to Treating Antimicrobial Resistant Infections, 3rd Edition

edited by

Michal Letek

and

Volker Behrends

submission deadline 31 Jul 2025 | 5 articles | Viewed by 11638 | Submission Open

Keywords: repurposing; anti-infectives; host-targeted therapies; bacteriophages; predatory bacteria; bacteriocins; antimicrobial peptides; nanoparticles; natural compounds; immunotherapy; probiotics; antibiotics

Antimicrobial Resistance in the Community Setting: The Other Side of the Coin

edited by

Luigi Principe

submission deadline 31 Jul 2025 | 4 articles | Viewed by 11218 | Submission Open

Keywords: emerging resistance; multidrug resistance; emerging virulence; community setting; Staphylococcus aureus; Enterococcus spp.; Streptococcus spp.; Haemophilus spp.; Moraxella spp.; Mycobacterium spp.; Neisseria spp.; Salmonella spp.; Shigella spp.; Campylobacter spp.; anaerobes; fungi

Genomic Analysis of Antimicrobial Drug-Resistant Bacteria

edited by

Maria Rosario Rodicio

and

Carlos Rodriguez-Lucas

submission deadline 31 Jul 2025 | 5 articles | Viewed by 11076 | Submission Open

Keywords: antimicrobial drug resistance; whole-genome sequencing; genomic epidemiology; one health; bacterial pathogens; mobile genetic elements; horizontal gene transfer; phylogenetics; evolution

(This special issue belongs to the Section Genetic and Biochemical Studies of Antibiotic Activity and Resistance)

Staphylococcal Biology and Pathogenesis

edited by Richard Proctor

submission deadline 31 Jul 2025 | 5 articles | Viewed by 8880 | Submission Open

Sepsis Management and Antibiotic Therapy

edited by

Egidia Gabriela Miftode

submission deadline 31 Jul 2025 | 5 articles | Viewed by 7954 | Submission Open

Keywords: sepsis; antibiotic therapy; infection; antimicrobial; antifungal

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Challenges and Emerging Strategies to Tackle the Global Burden of Antimicrobial Resistance

edited by

Tomislav Meštrović

submission deadline 31 Jul 2025 | 3 articles | Viewed by 7289 | Submission Open

Keywords: antimicrobial resistance (AMR); global burden of AMR; AMR in the context of public and global health; diagnostic and treatment of AMR; new approaches to AMR surveillance; antibiotic stewardship; local and global policy initiatives on AMR; prevention of AMR

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Clinical Guidelines and Real Practice of Antimicrobial Pharmacotherapy

edited by

Darko Modun

submission deadline 31 Jul 2025 | 5 articles | Viewed by 6867 | Submission Open

Keywords: adverse drug reaction; patient adherence; antimicrobial resistance; clinical guidelines; clinical settings; regional factors; pharmacotherapy

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Strategies for Combatting Multidrug-Resistant and Extensively Drug-Resistant Bacteria, 2nd Edition

edited by

Bożena Futoma-Kołoch

, Anna Kędziora and

Adriána Liptáková

submission deadline 31 Jul 2025 | 5 articles | Viewed by 6453 | Submission Open

Keywords: MDR bacteria; EDR bacteria; novel antimicrobial drugs; novel therapeutical approaches against MDR; novel therapeutical approaches against EDR; guidelines; personalized microbiota; bacteriophages; autovaccine therapy; antimicrobial stewardship

(This special issue belongs to the Section The Global Need for Effective Antibiotics)

Antimicrobial and Antibiofilm Activity by Natural Compounds

edited by

Galdino Andrade

Sueli F. Yamada-Ogatta

and Martha Viviana Torres Cely

submission deadline 31 Jul 2025 | 4 articles | Viewed by 5340 | Submission Open

Keywords: pathogens; human; animal; crops; antibiotic

(This special issue belongs to the Section Plant-Derived Antibiotics)

Antibacterial, Antibiofilm and Anti-virulence Activity Research of Both Natural and Synthetic Products, 2nd Edition

edited by

Eliana De Gregorio

and

Anna Esposito

submission deadline 31 Jul 2025 | 2 articles | Viewed by 5150 | Submission Open

Keywords: antimicrobial agent; antibiofilm agent; synergy between new antimicrobial products and conventional antibiotics; anti-virulence agent; mechanism of drug action; repurposing of approved drugs as antibacterial agent; biofilms; virulence factors

(This special issue belongs to the Section Plant-Derived Antibiotics)

Antibiotics Use and Stewardship in Hospitals and Outpatient Care Facilities, 2nd Edition

edited by

Islam M. Ghazi

and Ahmed El Yazbi

submission deadline 31 Jul 2025 | 3 articles | Viewed by 4953 | Submission Open

Keywords: antimicrobial stewardship; novel antibiotics; microbial resistance; optimizing treatment; pharmacokintics/pharmacodynamics

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Orthopedic Infections: Epidemiology and Antimicrobial Treatment

edited by Éric Bonnet

submission deadline 31 Jul 2025 | 4 articles | Viewed by 4684 | Submission Open

Keywords: chronic osteomyelitis; prosthetic joint infections; epidemiology; microbiology; antimicrobial treatment; treatment duration; local antibiotics

Rational Use of Antibiotics in Veterinary Medicine

edited by

JeongWoo Kang

submission deadline 31 Jul 2025 | 2 articles | Viewed by 4445 | Submission Open

Keywords: good manufacturing practice (GMP) in antibiotic production; research and systems in antibiotic quality control; consequences of improper antibiotic use; antibiotic stewardship programs; antibiotic resistance management

(This special issue belongs to the Section Antibiotics in Animal Health)

Emerging Challenges in Food Safety: Addressing Antimicrobial Resistance, Virulence Factors, and Biofilm Formation in Food-Borne Pathogens

edited by

Liora Mihaela Colobățiu

, Marian Mihaiu and

Zorita Diaconeasa

submission deadline 31 Jul 2025 | 2 articles | Viewed by 3150 | Submission Open

Keywords: antimicrobial resistance; food-borne pathogens; food safety; virulence factors; biofilm formation; resistance genes; food production; public health; molecular epidemiology; infection control

Managing Appropriate Antibiotic Prescribing and Use in Primary Care

edited by

Ruby Biezen

submission deadline 31 Jul 2025 | 3 articles | Viewed by 2358 | Submission Open

Keywords: primary care; general practice; antimicrobial stewardship; antimicrobial resistance; infectious disease; appropriate prescribing; guidelines concordance

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Peptide Antibiotics from Microbes and Venomous Animals, 2nd Edition

edited by

Jean-Marc Sabatier

submission deadline 31 Jul 2025 | 1 articles | Viewed by 2312 | Submission Open

Keywords: peptide antibiotics; antibacterial peptide; bacteria; microbe; venomous animal; bacteriocin; venom

(This special issue belongs to the Section Antimicrobial Peptides)

Pathogenic and Antibiotic-Resistant Bacteria in Gut Microbiota

edited by

Bing-Mu Hsu

submission deadline 31 Jul 2025 | 2 articles | Viewed by 2022 | Submission Open

Keywords: gut microbiota; pathogenic bacteria; antibiotic resistance; gastrointestinal tract; microbiome dynamics; host– pathogen interactions; transmission dynamics; therapeutic interventions; antibiotic stewardship; public health strategies

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Beyond Phages: Exploring Endolysins as Key Players in the Future of Antibacterial Therapeutics

edited by

Pilar García Suárez

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1637 | Submission Open

Keywords: endolysins; bacteriophages; phage therapy; antimicrobial resistance; clinical trials; regulatory framework

(This special issue belongs to the Section Bacteriophages)

The Antibiotic Resistance and Virulence Genes of Pathogens in Aquatic and Soil Environment

edited by

Bing Li

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1622 | Submission Open

Keywords: antibiotic resistance genes (ARGs); virulence genes; pathogenic bacteria; horizontal gene transfer

Virulence, Antimicrobial Resistance and Biofilm Production in Veterinary, Zoonotic and Food-Related Pathogens

edited by Óscar Mencía-Ares, Paula Fernández-Gómez and

Sonia Martinez

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1451 | Submission Open

Keywords: animal health; antimicrobial resistance; biofilm; food-borne pathogens; microbiology; pathogenicity; public health; veterinary pathogens; virulence; zoonosis

Knowledge, Attitudes and Practices of Antimicrobial Resistance and Stewardship in Primary Care Setting: From Understanding to Informing Interventions

edited by

Amanj Kurdi

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1390 | Submission Open

Keywords: antimicrobial resistance; antimicrobial stewardship; primary care; knowledge; attitudes and practices; antimicrobial stewardship interventions

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Antifungal Strategies: Epidemiological Approaches, Mechanisms and Resistance in Fungal Pathogens

edited by

Erick Martinez-Herrera

Rodolfo Pinto-Almazán

and

Carmen Rodríguez-Cerdeira

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1231 | Submission Open

Keywords: antifungal strategies; epidemiology; antifungal resistance; antifungal mechanisms; resistance genes

(This special issue belongs to the Section Fungi and Their Metabolites)

The Worldwide Problem of Antifungal Resistance: From Basic to Clinic

edited by

Max Carlos Ramírez-Soto

and

Alexandro Bonifaz

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1114 | Submission Open

Keywords: antifungal agents; antifungal resistance; fungal pathogens; pharmacology; therapeutic use

Antimicrobial Resistance and One Health: New Solutions for an Old Problem?

edited by

David Rodríguez-Lázaro

and

José María Eiros-Bouza

submission deadline 31 Jul 2025 | 1 articles | Viewed by 898 | Submission Open

Keywords: antimicrobial resistance; one health; global health; surveillance; primary porduction; food safety; environment health; nosocomial infections

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Multidrug-Resistant Pathogens: Genomic Analysis, Resistance Mechanisms, and Clinical Challenges

edited by

Dusan Kekic

and Nemanja Stanisavljevic

submission deadline 31 Jul 2025 | 1 articles | Viewed by 552 | Submission Open

Keywords: multidrug-resistant pathogens; genomic analysis; antimicrobial resistance; resistance mechanisms; antimicrobial therapy challenges; new antimicrobial drugs and therapies; clinical antimicrobial guidelines

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Secondary Metabolites from Natural Sources: Mechanisms of Antimicrobial Action and Therapeutic Potential

edited by

Fatima Cerqueira

and

Maria Pia Ferraz

submission deadline 31 Jul 2025 | 1 articles | Viewed by 498 | Submission Open

Keywords: secondary metabolites; bioactive compounds

(This special issue belongs to the Section Plant-Derived Antibiotics)

Helicobacter pylori Virulence Factors, Antibiotic Susceptibility and Persistent Infection

edited by

Mara Di Giulio

Teresa Fasciana

and

Chiara Pagliuca

submission deadline 31 Jul 2025 | Viewed by 319 | Submission Open

Keywords: Antimicrobial drugs and therapies; virulence factors; pathogenesis; extra-digestive diseases; gastric microbioma

Application of Next Generation Sequencing for Studying the Resistance of Environmental Pathogens

edited by Skoulakis Anargyros and

Efthymia Petinaki

submission deadline 31 Jul 2025 | Viewed by 261 | Submission Open

Keywords: next generation sequencing; metagenome; environmental pathogens; bioinformatics; antimicrobial resistant determinants; virulence factors

Antibacterial and Antibiofilm Properties of Biomaterial

edited by

Ziba Najmi

and Alessandro Calogero Scalia

submission deadline 31 Jul 2025 | Viewed by 186 | Submission Open

Keywords: biomaterials surfaces; coating; biofilm formation; biofilm eradication

(This special issue belongs to the Section Antibiofilm Strategies)

Current Challenges in Antimicrobial Stewardship

edited by

Andreas A. Von Ameln-Mayerhofer

submission deadline 31 Jul 2025 | Viewed by 140 | Submission Open

Keywords: antimicrobial stewardship; antimicrobial resistance; antibiotics prescribing; intervention; irrational prescriptions; surveillance; therapeutic monitoring; ABS; AMS; antibiotic stewardship; best practice; interprofessional; rational prescribing; DDD/100; RDD/100

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Interdisciplinary Applications of Micro- and Nano-Antimicrobials

edited by Cleonice Gonçalves da Rosa and Michael Ramos Nunes

submission deadline 31 Jul 2025 | Viewed by 139 | Submission Open

Keywords: micro- and nano-antimicrobials; antimicrobial coatings; nanotechnology in medicine; food safety and packaging; agricultural applications; antibiotic resistance; environmental remediation; controlled release systems; pathogen management; antimicrobial materials

(This special issue belongs to the Section Novel Antimicrobial Agents)

Plant Extracts and Their Derivatives with Antimicrobial Activities

edited by