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Antioxidants
Special Issues
Early Metabolic Programming Mediated by Oxidative Stress
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Early Metabolic Programming Mediated by Oxidative Stress

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 20 May 2025 | Viewed by 1121

Special Issue Editors

Prof. Dr. Javier Diaz-Castro

E-Mail Website
Guest Editor
Department of Physiology, Faculty of Pharmacy, Campus Universitario de Cartuja, University of Granada, 18071 Granada, Spain
Interests: pregnancy; lactation; nutrition; perinatal nutrition; pregnancy; oxidative stress; antioxidant system; inflammation; physical activity; endocrine function; early programming
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Julio J. Ochoa Herrera

E-Mail Website
Guest Editor
Department of Physiology, Faculty of Pharmacy, Campus Universitario de Cartuja, University of Granada, 18071 Granada, Spain
Interests: pregnancy; lactation; nutrition; perinatal nutrition; oxidative stress; antioxidant system; inflammation; physical activity; endocrine function
Special Issues, Collections and Topics in MDPI journals
Dr. Jorge Moreno-Fernandez

E-Mail Website
Guest Editor
Department of Physiology, Faculty of Pharmacy, Campus Universitario de Cartuja, University of Granada, 18071 Granada, Spain
Interests: physiology; nutrition; molecular biology; fermentation; food sciences; biochemistry; antioxidants; oxidative stress; pediatrics; maternal; prematurity; colostrum; neonatal nutrition; obstetrics and gynecology; perinatal nutrition
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Maternal and perinatal oxidative stress is critical for the developmental origins of health and disease, while specific antioxidant and nutrient supplementations may serve as reprogramming strategies to prevent many diseases. The role of perinatal oxidative stress in the onset of insulin resistance, central nervous system development, cardiovascular diseases, early aging postnatal development and the possible interventions that may prevent or reduce such effects is a field of interest in the scientific literature. On the other hand, mitochondria are particularly adept at mediating early metabolic programming by oxidative stress, and they serve as subcellular substrates in the programming process at the same time. This Special Issue aims to gather current knowledge on the interplay of maternal oxidative stress during pregnancy and breastfeeding and the response to early-life insults to assess its impact on developmental programming during in utero and early postnatal life, because research into oxidative stress that begins early in life will have profound implications for future health.

Prof. Dr. Javier Diaz-Castro
Prof. Dr. Julio J. Ochoa Herrera
Dr. Jorge Moreno-Fernandez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolic programming
  • oxidative stress
  • antioxidants
  • mitochondria
  • inflammatory signaling
  • reactive oxygen species
  • trace elements
  • nutrition
  • gestation
  • offspring
  • pregnancy
  • breastfeeding
 

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Published Papers (1 paper)

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39 pages, 1382 KiB  
Systematic Review
The Use of Antioxidants for Cardiovascular Protection in Fetal Growth Restriction: A Systematic Review
by Charmaine R. Rock, Suzanne L. Miller and Beth J. Allison
Antioxidants 2024, 13(11), 1400; https://doi.org/10.3390/antiox13111400 - 15 Nov 2024
Viewed by 363
Abstract
Fetal growth restriction (FGR) increases the risk of cardiovascular disease. There are currently no treatment options available; however, antioxidants have shown potential to improve cardiovascular deficits associated with FGR. This systematic review aimed to determine whether antenatal antioxidant intervention can effectively protect the [...] Read more.
Fetal growth restriction (FGR) increases the risk of cardiovascular disease. There are currently no treatment options available; however, antioxidants have shown potential to improve cardiovascular deficits associated with FGR. This systematic review aimed to determine whether antenatal antioxidant intervention can effectively protect the developing cardiovascular system in FGR. We searched for interventional studies that used an antenatal antioxidant intervention to improve cardiac and/or vascular outcomes in FGR published between 01/1946 and 09/2024 using MEDLINE and Embase (PROSPERO: CRD42024503756). The risk of bias was assessed with SYRCLE. The studies were assessed for cardiovascular protection based on the percentage of cardiac and/or vascular deficits that were restored with the antioxidant treatment. Studies were characterised as showing strong cardiovascular protection (≥50% restoration), mild cardiovascular protection (>0% but <50% restoration), an antioxidant-only effect (this did not include control group which showed a change with antioxidant intervention compared to FGR) or no cardiovascular protection (0% restoration). Thirty-eight publications met the inclusion criteria, encompassing 43 studies and investigating 15 antioxidant interventions. Moreover, 29/43 studies (71%) reported the restoration of at least one cardiac or vascular deficit with antioxidant intervention, and 21/43 studies (51%) were classified as strong cardiovascular protection. An ex vivo analysis of the arterial function in seven studies revealed endothelial dysfunction in growth-restricted offspring and antioxidant interventions restored the endothelial function in all cases. Additionally, four studies demonstrated that antioxidants reduced peroxynitrite-mediated oxidative stress. Notably, only 13/43 studies (32%) delayed antioxidant administration until after the induction of FGR. Antenatal antioxidant interventions show promise for providing cardiovascular protection in FGR. Melatonin was the most frequently studied intervention followed by nMitoQ, vitamin C and N-acetylcysteine, all of which demonstrated a strong capacity to reduce oxidative stress and improve nitric oxide bioavailability in the cardiovascular system of growth-restricted offspring; however, this systematic review highlights critical knowledge gaps and inconsistencies in preclinical research, which hinder our ability to determine which antioxidant treatments are currently suitable for clinical translation. Full article
(This article belongs to the Special Issue Early Metabolic Programming Mediated by Oxidative Stress)
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