Antioxidants

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Dear Colleagues,

Population ageing is one of humanity’s greatest triumphs and at the same time one of our greatest challenges. Ageing is the progressive deterioration of physiological function with increasing age and is among the most important known risk factors for most chronic diseases. Oxidative stress plays a crucial role in the development of age-related diseases, including arthritis, diabetes, dementia, cancer, atherosclerosis, vascular diseases, obesity, osteoporosis, and metabolic syndromes, while well-designed antioxidant strategies have been suggested for healthy ageing and for preventing or alleviating age-related diseases.

In this Special Issue, we aim to collect experimental research, clinical research, and epidemiological studies focused on the interactions between dietary antioxidants and ageing and age-related diseases that contribute to the promotion of healthy and active ageing. Articles describing novel bioactive nutrients and those highlighting the role of oxidative stress or redox-interplay-mediated mechanisms in the origins and development of diseases are especially welcomed.

Dr. Sihui Ma
Prof. Dr. Consuelo Borras
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

age-associated diseases
senescence
dietary antioxidants
antioxidant bioactive nutrients
sarcopenia
frailty
inflammation

Published Papers (2 papers)

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Research

19 pages, 4183 KiB

Open AccessArticle

Cocoa Polyphenols Prevent Age-Related Hearing Loss and Frailty in an In Vivo Model

by Rosalía Fátima Heredia, Juan I. Riestra-Ayora, Joaquín Yanes-Díaz, Israel John Thuissard Vasallo, Cristina Andreu-Vázquez, Ricardo Sanz-Fernández and Carolina Sánchez-Rodríguez

Antioxidants 2023, 12(11), 1994; https://doi.org/10.3390/antiox12111994 - 12 Nov 2023

Cited by 1 | Viewed by 1225

Abstract

Age-related hearing loss (ARHL) impairs the quality of life in elderly persons. ARHL is associated with comorbidities, such as depression, falls, or frailty. Frailty syndrome is related to poor health outcomes in old age. ARHL is a potentially modifiable risk factor for frailty. Oxidative stress has been proposed as a key factor underlying the onset and/or development of ARHL and frailty. Cocoa has high levels of polyphenols and provides many health benefits due to its antioxidant properties. Male and female C57Bl/6J mice were randomly assigned to two study groups: animals receiving a cocoa-supplemented diet and the other receiving a standard diet. Then, at the ages of 6, 14, and 22 months, hearing and frailty were measured in all mice. Auditory steady-state responses (ASSR) threshold shifts were measured to different frequencies. The frailty score was based on the “Valencia Score” adapted to the experimental animals. The total antioxidant capacity and total polyphenols in urine samples were also measured. Significant improvements in hearing ability are observed in the cocoa groups at 6, 14, and 22 months compared to the no cocoa group. The cocoa diet significantly retards the development of frailty in mice. Cocoa increases the concentration of polyphenols excreted in the urine, which increases the total antioxidant capacity. In conclusion, cocoa, due to its antioxidant properties, leads to significant protection against ARHL and frailty. Full article

(This article belongs to the Special Issue Dietary Antioxidants, Age-Associated Diseases, and Active Ageing: An Update)

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16 pages, 10031 KiB

Open AccessArticle

Protective Actions of Cannabidiol on Aging-Related Inflammation, Oxidative Stress and Apoptosis Alterations in Liver and Lung of Long Evans Rats

by Lisa Rancan, Beatriz Linillos-Pradillo, Julia Centeno, Sergio D. Paredes, Elena Vara and Jesús A. F. Tresguerres

Antioxidants 2023, 12(10), 1837; https://doi.org/10.3390/antiox12101837 - 9 Oct 2023

Cited by 2 | Viewed by 1331

Abstract

Background: Aging is characterised by the progressive accumulation of oxidative damage which leads to inflammation and apoptosis in cells. This affects all tissues in the body causing the deterioration of several organs. Previous studies observed that cannabidiol (CBD) could extend lifespan and health span by its antioxidant, anti-inflammatory and autophagy properties. However, research on the anti-aging effect of CBD is still in the beginning stages. This study aimed to investigate the role of cannabidiol (CBD) in the prevention of age-related alterations in liver and lung using a murine model. Methods: 15-month-old Long Evans rats were treated with 10 mg/kg b.w./day of CBD for 10 weeks and compared to animals of the same age as old control and 2-month-old animals as young control. Gene and/or protein expressions, by RT-qPCR and Western blotting, respectively, were assessed in terms of molecules related to oxidative stress (GST, GPx, GR and HO-1d), inflammation (NFκB, IL-1β and TNF-α) and apoptosis (BAX, Bcl-2, AIF, and CASP-1). In addition, MDA and MPO levels were measured by colorimetric assay. Results were analysed by ANOVA followed by Tukey–Kramer test, considering statistically significant a p < 0.05. Results: GST, GPx and GR expressions were significantly reduced (p < 0.01) in liver samples from old animals compared to young ones and CBD treatment was able to revert it. A significant increase was observed in old animals compared to young ones in relation to oxidative stress markers (MDA and HO-1d), proinflammatory molecules (NFκB, IL-1β and TNF-α), MPO levels and proapoptotic molecules (BAX, AIF and CASP-1), while no significant alterations were observed in the antiapoptotic molecules (Bcl-2). All these changes were more noticeable in the liver, while the lung seemed to be less affected. In almost all the measured parameters, CBD treatment was able to revert the alterations caused by age restoring the levels to those observed in the group of young animals. Conclusions: Chronic treatment with CBD in 15-month-old rats showed beneficial effects in lung and more significantly in liver by reducing the levels of inflammatory, oxidative and apoptotic mediators, and hence the cell damage associated with these three processes inherent to aging. Full article

(This article belongs to the Special Issue Dietary Antioxidants, Age-Associated Diseases, and Active Ageing: An Update)

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