The Role of Extracellular Vesicles in Aging and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (30 January 2023) | Viewed by 24314
Special Issue Editors
Interests: aging; senescence; stem cells; oxidative stress; sex
Special Issues, Collections and Topics in MDPI journals
Interests: stem cells; physioxia; oxidative stress; senescence; apoptosis; autophagy; aging
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
As cells accumulate damage over time, they respond by individual cell fate decisions that disrupt tissue homeostasis, thus leading to organ dysfunction and increased morbidity. Extracellular vesicles (EVs) are known to be able to modulate the aging process by restoring the microenvironment and promoting tissue regeneration. Thus, EVs are promising therapeutic tools, especially in the field of aging and diseases.
However, there is still a long way before EVs can be used at the clinic. Standardization of the methodology, reproducibility and data comparison are major outcomes that must be improved in order to achieve EV-based therapeutics. Therefore, in this Special Issue, we encourage scientists to contribute original articles or reviews describing EV sources, collection and purification methods, as well as EV synthetic designs, such as drug delivery carriers.
Since EV bioactive cargo (proteins, miRNA, lipids) is altered depending on the physio-pathological conditions, we are also looking for studies on EVs’ functional effect on target cells and the underlying mechanisms or signaling pathways that are involved in the process. Finally, we will also welcome research on EV applications for expanding health span, as well as EV use as early biomarkers for disease detection.
Prof. Dr. Consuelo Borras
Dr. Cristina Mas-Bargues
Guest Editors
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Keywords
- extracellular vesicles
- EV-based therapeutics
- aging
- disease
- biomarkers
- regenerative medicine
- stem cells
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