Antioxidants

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Dear Colleagues,

Natural antioxidants are widely distributed in food and medicinal plants and differ in their composition, physical and chemical properties. Due to their diverse components, they exhibit a wide spectrum of biological effects and mechanisms of action and have been a productive source of lead compounds for the development of novel therapeutics.

Oxidative stress causes damage to proteins, lipids and DNA and occurs when ROS accumulate in cells due to an imbalance between ROS production and the antioxidant system. Numerous studies have demonstrated that ROS play a crucial role in the pathophysiology of a variety of diseases, including cardiovascular and cerebrovascular diseases, which are regarded as one of the major causes of mortality worldwide.

This Special Issue focuses on new findings related to natural antioxidants and their relevance to cardiovascular and cerebrovascular diseases. This issue also welcomes contributions on the role of ROS at the cellular level, providing more knowledge about oxidative damage mechanisms in cells, organelles and signaling molecules. Authors are invited to submit both original research papers and review articles.

Dr. Yi-Sook Jung
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

natural antioxidant
oxidative stress
reactive oxygen species
cardiovascular disease
cerebrovascular disease

Published Papers (2 papers)

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Research

Jump to: Review

15 pages, 451 KiB

Open AccessArticle

Selenoprotein P, Peroxiredoxin-5, Renalase and Selected Cardiovascular Consequences Tested in Ambulatory Blood Pressure Monitoring and Echocardiography

by Karolina Czerwińska, Lidia Januszewska, Iwona Markiewicz-Górka, Aleksandra Jaremków, Helena Martynowicz, Krystyna Pawlas, Grzegorz Mazur, Rafał Poręba and Paweł Gać

Antioxidants 2023, 12(6), 1187; https://doi.org/10.3390/antiox12061187 - 30 May 2023

Cited by 1 | Viewed by 1558

Abstract

This study aimed to assess the relationship between chosen antioxidants, namely selenoprotein P (SELENOP), peroxiredoxin-5 (Prdx-5), renalase and selected cardiovascular consequences tested in ambulatory blood pressure monitoring (ABPM) and echocardiography (ECHO). In our work, cardiovascular consequences refer to higher mean blood pressure (MBP) and pulse pressure (PP) on ABPM, as well as to left atrial enlargement (LAE), left ventricular hypertrophy (LVH) and lower left ventricular ejection fraction (LVEF%) on ECHO. The study group consisted of 101 consecutive patients admitted to the Department of Internal Medicine, Occupational Diseases and Hypertension to verify the diagnosis of Obstructive Sleep Apnoea (OSA). Each patient underwent full polysomnography, blood tests, ABPM and ECHO. Both selenoprotein-P and renalase levels correlated with different ABPM and ECHO parameters. We found no correlation between the peroxiredoxin-5 level and none of the tested parameters. We point to the possible application of SELENOP plasma-level testing in the initial selection of high cardiovascular-risk patients, especially if access to more advanced examinations is limited. We further suggest SELENOP measurement as a possible indicator of patients at increased left ventricular hypertrophy risk who should be of particular interest and may benefit from ECHO testing. Full article

(This article belongs to the Special Issue Natural Antioxidants for Cardiovascular and Cerebrovascular Disease)

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Review

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30 pages, 2767 KiB

Open AccessReview

Sphingolipids and Atherosclerosis: The Dual Role of Ceramide and Sphingosine-1-Phosphate

by Marco Piccoli, Federica Cirillo, Andrea Ghiroldi, Paola Rota, Simona Coviello, Adriana Tarantino, Paolo La Rocca, Ivana Lavota, Pasquale Creo, Paola Signorelli, Carlo Pappone and Luigi Anastasia

Antioxidants 2023, 12(1), 143; https://doi.org/10.3390/antiox12010143 - 6 Jan 2023

Cited by 13 | Viewed by 2394

Abstract

Sphingolipids are bioactive molecules that play either pro- and anti-atherogenic roles in the formation and maturation of atherosclerotic plaques. Among SLs, ceramide and sphingosine-1-phosphate showed antithetic properties in regulating various molecular mechanisms and have emerged as novel potential targets for regulating the development of atherosclerosis. In particular, maintaining the balance of the so-called ceramide/S1P rheostat is important to prevent the occurrence of endothelial dysfunction, which is the trigger for the entire atherosclerotic process and is strongly associated with increased oxidative stress. In addition, these two sphingolipids, together with many other sphingolipid mediators, are directly involved in the progression of atherogenesis and the formation of atherosclerotic plaques by promoting the oxidation of low-density lipoproteins (LDL) and influencing the vascular smooth muscle cell phenotype. The modulation of ceramide and S1P levels may therefore allow the development of new antioxidant therapies that can prevent or at least impair the onset of atherogenesis, which would ultimately improve the quality of life of patients with coronary artery disease and significantly reduce their mortality. Full article

(This article belongs to the Special Issue Natural Antioxidants for Cardiovascular and Cerebrovascular Disease)

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