NADPH Oxidases in Health and Aging—2nd Edition
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 15 January 2025 | Viewed by 143
Special Issue Editors
Interests: oxidative stress; genetic/epigenetic modulators of CV function
Special Issues, Collections and Topics in MDPI journals
Interests: redox signaling; NADPH oxidases; VSMC biology;aging; atherosclerosis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In view of the great response that we received for the previous Special Issue "NADPH Oxidases in Health and Aging", we decided to come up with its second edition.
Reactive oxygen species (ROS) play an important role in normal physiological processes such as blood pressure control and renal and central nervous system functions. However, ROS levels increase with aging, making it a risk factor for cardiovascular, pulmonary, renal, and neurological diseases. Nox family NADPH oxidases, whose sole function is the production of ROS, are differentially expressed in the cells of the above systems. NADPH oxidases are induced or activated by various risk factors associated with cardiovascular, pulmonary, renal, and neurological diseases, and the resulting persistent increase in ROS levels induce inflammation and fibrosis and the remodeling of the organ systems, increasing the disease severity. The concurrence of risk factors with old age adds to the disease burden. Even in apparently healthy people, differences in the expression pattern of NADPH oxidases in different tissues and organs affects disease risk based on ROS threshold levels, which has not been systematically addressed.
The aim for this Special Issue is to publish review articles on the regulation of redox signaling by NADPH oxidase in the physiology and pathophysiology of cardiovascular and pulmonary systems and neuronal networks, with emphasis on aging where pertinent.
We trust that the Special Issue will provide new insights into the function of NADPH oxidases in aging-associated increase in cardiovascular, pulmonary, renal, and neurological diseases.
Prof. Dr. Marschall S. Runge
Dr. Nageswara R. Madamanchi
Guest Editors
Manuscript Submission Information
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Keywords
- redox signaling
- NADPH oxidases
- reactive oxygen species (ROS)
- aging
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