Therapeutic Effects of Natural Antioxidants on Skin Inflammation and Allergy

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (20 April 2024) | Viewed by 567

Special Issue Editor


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Guest Editor
Nutritional Education Major, Graduate School of Education, Dong-A University, Busan 49315, Republic of Korea
Interests: natural compounds; antioxidants; atopic dermatitis; skin inflammation; allergy

Special Issue Information

Dear Colleagues,

Oxidative stress is a dominant factor in inflammatory skin diseases as it regulates the biological components that mediate such diseases. These active substances are reactive species, mainly including reactive oxygen species (ROS), reactive nitrogen species (RNS), and reactive sulfur species (RSS), which damage biomolecules such as lipids, proteins, and DNA.

Antioxidants, which can be endogenous or exogenous, are substances that neutralize ROS and protect the cells. Natural antioxidants are exogenous components that can be extracted from natural sources, such as plants, fruits, vegetables, herbs, spices, tea, and insects. They are safe and useful for food and cosmetic formulation. Particularly, they can improve skin health by reducing DNA damage from UV light, improving hydration, stimulating collagen and elastin production, reducing wrinkles and pigmentation, supporting healing processes, and reducing inflammation.

Therefore, this Special Issue aims to collate papers that examine the therapeutic effects of natural antioxidants on skin inflammation and allergy. Topics include the following: (1) mechanisms of oxidative stress and antioxidant defense in skin; (2) sources and properties of natural antioxidants for skin care; (3) methods and challenges of incorporating natural antioxidants into skin care products or cosmetics; (4) clinical evidence and future perspectives of using natural antioxidants for treating skin inflammation and allergy.

We look forward to your contribution.

Dr. Eun-kyung Kim
Guest Editor

Manuscript Submission Information

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Keywords

  • natural antioxidants
  • skin health
  • skin inflammation
  • skin allergy
  • dermatitis treatment
  • antioxidant-rich skincare

Published Papers (1 paper)

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Research

17 pages, 6956 KiB  
Article
Papain Suppresses Atopic Skin Inflammation through Anti-Inflammatory Activities Using In Vitro and In Vivo Models
by Hye-Min Kim, Yun-Mi Kang, Minho Lee and Hyo-Jin An
Antioxidants 2024, 13(8), 928; https://doi.org/10.3390/antiox13080928 (registering DOI) - 30 Jul 2024
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Abstract
Papain (PN) is a proteolytic enzyme derived from Carica Papaya L. While the pharmacological effects of PN have not been extensively studied compared to its enzymatic activity, PN also holds potential benefits beyond protein digestion. This study aimed to investigate the potential effects [...] Read more.
Papain (PN) is a proteolytic enzyme derived from Carica Papaya L. While the pharmacological effects of PN have not been extensively studied compared to its enzymatic activity, PN also holds potential benefits beyond protein digestion. This study aimed to investigate the potential effects of PN against skin inflammation in house dust mite Dermatophagoides farinae body (Dfb)-exposed NC/Nga atopic dermatitis (AD) mice and human HaCaT keratinocytes and their underlying mechanisms. The effects of PN on the skin were assessed via histological examination, measurements of transepidermal water loss (TEWL), quantitative reverse transcription-polymerase chain reaction, Western blotting, and enzyme-linked immunosorbent assay. Our findings indicated that the oral intake of PN decreased the severity scores of lesions resembling AD, TEWL, and the levels of inflammatory cytokines and serum immunoglobulin E in Dfb-induced AD mice, along with a reduction in epidermal thickness and mast cell infiltration. Additionally, PN inhibited the activation of the mitogen-activated protein kinases (MAPKs) and the signal transducer and activator of transcription (STAT) pathways in Dfb-induced AD mice and HaCaT keratinocytes. Moreover, PN improved survival and reduced ROS production in H2O2-damaged HaCaT keratinocytes and enhanced the expression of antioxidant enzymes in Dfb-induced AD mice. Concludingly, the oral administration of PN suppressed inflammatory mediators and downregulated the MAPKs/STAT pathway, suggesting its potential role in AD pathogenesis. Full article
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